Abstract：
BACKGROUND:Small size at birth may be associated with impaired cognitive ability later in life. The aim of this study was to examine the effect of being born small for gestational age (SGA), with or without intrauterine growth restriction (IUGR) on cognitive ability in late adolescence. STUDY DESIGN:A follow-up study of a former cohort included 123 participants (52 males); 47 born SGA and 76 born appropriate for gestational age (AGA). Fetal growth velocity (FGV) was determined by serial ultrasound measurements during the third trimester. A control group matched for age and birthplace was included. The original Wechsler Adult Intelligence Scale (WAIS) was administered, and verbal, performance and full-scale Intelligence Quotient (IQ) scores were calculated. RESULTS:There was no difference in IQ between adolescents born SGA and AGA. FGV or IUGR during the third trimester did not influence cognitive ability in late adolescence. Full-scale IQ was positively related to head circumference (HC) in adolescence (B: 1.30, 95% CI: 0.32-2.28, p=0.01). HC at birth and three months was positively associated with full-scale IQ. Catch-up growth in the group of SGA children was associated with a significantly increased height, larger HC, increased levels of insulin-like growth factor-I (IGF-I) and increased full-scale IQ compared to those born SGA without catch-up growth. CONCLUSION:SGA and IUGR may not be harmful for adult cognitive ability, at least not in individuals born at near-term. However, known risk factors of impaired fetal growth may explain the link between early growth and cognitive ability in adulthood.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Jensen RB,Juul A,Larsen T,Mortensen EL,Greisen Gdoi
10.1016/j.earlhumdev.2015.08.014subject
Has Abstractpub_date
2015-12-01 00:00:00pages
755-60issue
12eissn
0378-3782issn
1872-6232pii
S0378-3782(15)00186-3journal_volume
91pub_type
杂志文章abstract：OBJECTIVES:To investigate the effects of single and repeated courses of antenatal corticosteroids on brain growth in very preterm babies. DESIGN:Retrospective study of 110 very preterm babies delivered at a single University Teaching Hospital between 1992 and 1999 who had a full necropsy including detailed examination...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(01)00144-x
更新日期：2001-07-01 00:00:00
abstract：:The aim of this study was to determine whether corticotropin-releasing hormone (CRH) regulates human trophoblast cell growth. The results showed that exogenous CRH significantly stimulated human trophoblast proliferation in first-trimester primary cultures. In vivo, CRH was strongly immunolocalised to cytotrophoblasti...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2004.04.010
更新日期：2004-08-01 00:00:00
abstract：:805 normal-for-age human embryos and fetuses were used to study early prenatal fat development. The investigation included observations on stages of fat morphogenesis at the light microscopic level and computerized image analyses of fat lobule size and number. The buccal fat pad was selected as a model system for the ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90028-2
更新日期：1983-03-01 00:00:00
abstract：:We describe the managment of 2 sets of pre-term quadruplets born to 2 women pregnant concurrently following the induction of ovulation with gonadotrophin. Careful antenatal planning was necessary to provide for each of the 8 pre-term infants a standard of neonatal medical and nursing care comparable to that normally a...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(77)90028-7
更新日期：1977-10-01 00:00:00
abstract：:Breast- and formula-fed infants were compared with regard to behavior patterns, especially crying behavior. A diary concerning seven behaviors was completed by 188 mothers of breast- and formula-fed infants at the well baby clinic. Breast-fed infants were fed more frequently with longer feeding duration. They slept mo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00071-2
更新日期：2000-05-01 00:00:00
abstract：:Newborn infants, especially preterm infants, have an immature immune system, which is not capable to actively protect against vaccine-preventable infections. Therefore, the newborn is dependent on transplacental transport of Immunoglobulin G (IgG), an active, FcRn receptor mediated process. Fetal IgG rises from approx...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2010.11.003
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:A short course of moderately early dexamethasone therapy with a starting dose of 0.5 mg/kg/day improves lung compliance and shortens the duration of ventilatory support in preterm infants with respiratory distress syndrome (RDS). We conducted a double-blind, randomized study to evaluate whether a moderately e...
journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-3782(03)00082-3
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:We hypothesized that morphine has a depressing effect on early brain activity, assessed using quantitative aEEG/EEG parameter and depressed activity will be associated with brain volumes at term in extremely preterm infants. STUDY DESIGN:174 preterm infants were enrolled in 3 European tertiary NICUs (mean GA...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.104970
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION:The 2D:4D digit ratio is sexually-dimorphic, probably due to testosterone action through the perinatal period. We characterize the 2D:4D ratio in newborn (NB) infants, in between the pre- and postnatal surges of testosterone, and relate it to the mother's 2D:4D and to testosterone levels in the amniotic fl...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.08.009
更新日期：2013-02-01 00:00:00
abstract：:Dexamethasone (DEX), a synthetic glucocorticoid, has been widely used to prevent the development of a variety of poor health conditions in premature infants including chronic lung disease, inflammation, circulatory failure, and shock. Although there are some reports of neurologic complications related to DEX exposure,...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.10.007
更新日期：2013-05-01 00:00:00
abstract：:Bronchopulmonary dysplasia (BPD) is one of the most important sequelae of premature birth and the most common form of chronic lung disease of infancy. From a clinical standpoint BPD subjects are characterized by recurrent respiratory symptoms, which are very frequent during the first years of life and, although becomi...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2013.07.015
更新日期：2013-10-01 00:00:00
abstract：:The modern successes of reproductive medicine are based on the achievements in the fields of artificial fertilization and cryobiology over the last 50years. Cryopreservation of oocytes makes it possible to preserve their reproductive potential after surgical interventions, treatment of cancer, for delayed pregnancy an...
journal_title：Early human development
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.earlhumdev.2018.08.016
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:Extremely low birth weight (ELBW; <1kg) adolescents are at risk for special health care needs (SHCN) and poor math achievement compared to normal birth weight (NBW) peers. SHCN are associated with poor academic achievement among NBW children. We hypothesize that SHCN explain the effect of ELBW on math achiev...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2017.09.019
更新日期：2017-12-01 00:00:00
abstract：:Fifty-five pregnant Rhesus isoimmunized women were subjected to fetal blood sampling or fetal blood transfusion on 135 occasions. Glucose and C-peptide concentrations were measured in fetal blood, in addition to the routine investigations for complete blood count, blood gases and lactate concentration, in order to inv...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90027-g
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND:Movement by an infant during the first year of life might influence its activity level and thereby influence growth in early childhood. AIM:To examine whether the time that an infant is able to move unrestrictedly and time spent in baby seats are related to weight and waist circumference at age 9 months and...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.04.002
更新日期：2013-07-01 00:00:00
abstract：:More than 10,000 preterm babies worldwide have been enrolled in trials evaluating probiotics administration for the prevention of necrotising enterocolitis, with very few adverse events reported. Despite this, probiotic safety is frequently cited as a concern when using this intervention. This review addresses why a p...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2019.05.016
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the pregnancy outcome in pregnancies with threatened abortion (miscarriage). MATERIAL AND METHOD:A prospective cohort study was performed on 1000 pregnant women. 500 women (case group), had a history of vaginal bleeding during the first half of pregnancy and the other 500 women (control group), d...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.02.005
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:We evaluated the effect of maternal administration of betamethasone (0.2 mg/kg per day) on mitogen-induced lymphocyte proliferation and interleukin-2 (IL-2) production by maternal, fetal, and neonatal rat splenic lymphocytes. STUDY DESIGN:Betamethasone was injected intramuscularly on days 19 and 20 of gestat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90028-0
更新日期：1994-01-01 00:00:00
abstract：:Psychobiological studies of fetal ontogenesis in non-human species, particularly in laboratory rat, now have much to offer students of human development. Psychobiological approaches are 'ecologically' oriented which, for fetal research, implies consideration of the adaptive significance of behavior within the uterine ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/0378-3782(93)90102-z
更新日期：1993-12-31 00:00:00
abstract：:Nurses worldwide have striven to establish nursing as a profession, autonomous but complementary to the medical profession. Literature as far back as the Renaissance demonstrates an overall derogatory attitude toward the nurse's role. The modern notion of the nurse working side by side the medical practitioner continu...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2020.105015
更新日期：2020-06-01 00:00:00
abstract：:Pancreatic protease deficiency may be an aetiological factor in enteritis necroticans, a disease sharing some features of necrotising enterocolitis (NEC). Using faecal chymotrypsin measurement we have prospectively studied pancreatic exocrine function in infants at risk of NEC. No significant difference was found comp...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90100-9
更新日期：1993-12-15 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.01.010
更新日期：2006-10-01 00:00:00
abstract：:Eleven healthy, full-term babies were studied on the second day (d2) after birth and again 4 weeks (w4) later. The babies lived in natural lighting conditions and were fed every 4 h. Blood pressure, heart rate, skin (abdomen) and rectal temperatures were measured at 10-min intervals for 24 h. Behavioural states (deep ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90039-6
更新日期：1994-02-01 00:00:00
abstract：:The reported energy content of infant formulas will vary, depending upon the method used to calculate or measure the caloric value. Manufacturers' specifications regarding the energy content of milk formulas reflects the 'metabolizable' energy. i.e., the amount of energy which is digested and absorbed by the infant. H...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90124-4
更新日期：1982-07-01 00:00:00
abstract：:Whether preeclampsia affects the fetal hematologic system still remains a controversial issue. The purpose of this series was to examine the hypothesis that preeclampsia may or may not cause adverse effects on fetal hemogram, including erythrocytes, leukocytes, and platelets. In addition, no one, to date, has reported...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90150-3
更新日期：1994-05-01 00:00:00
abstract：:Comparisons of the components of ventilator waveform were made in two groups of preterm infants ventilated for the respiratory distress syndrome. Infants actively expiring against positive pressure inflation were compared to infants not showing this interaction. The actively expiring infants were ventilated with a hig...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(88)80051-3
更新日期：1988-05-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)00073-x
更新日期：1998-04-17 00:00:00
abstract：:Atrial natriuretic factor (ANF) has been well known as a potent natriuretic peptide. The purpose of this study was to clarify the physiological role of ANF in neonates. We designed two types of study to investigate the role of ANF in neonates. (i) The role of ANF in neonatal fluid homeostasis; (ii) ANF and spontaneous...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90132-z
更新日期：1992-06-01 00:00:00
abstract：:Infants born at term frequently require mechanical ventilation and suffer significant mortality and morbidity. Yet, there have been few randomised trials (RCTs) exclusively of term born infants and when term born infants have been included in studies, a sub-analysis of their results has rarely been undertaken. The lim...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2012.09.012
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Kangaroo care, i.e., skin-to-skin cohabitation (SSC) between an infant and caregiver, is often used in neonatal intensive care units to promote bonding, breastfeeding and infant growth. The direct salutary effects of SSC on cardio-respiratory control in preterm infants remain equivocal; some reports suggest ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.08.015
更新日期：2014-12-01 00:00:00
