Abstract：
OBJECTIVE:To determine whether placental lesions are risk factors for neurologic morbidities in intrauterine growth restricted (IUGR) infants, we compared the incidence of cranial ultrasound (CUS) abnormalities and the number and type of placental lesions in IUGR cases and gestational age-matched appropriate for gestational age (AGA) controls. STUDY DESIGN:Retrospective case-control study of 94 singleton IUGR and 145 AGA infants. Medical records, CUS reports, and placental histology were reviewed. Analyses included chi2, t-test, analysis of variance and logistic regressions to identify those variables significantly associated with IUGR and those associated with CUS abnormalities. RESULTS:The incidence of CUS abnormalities was 1.7-fold higher in IUGR cases (50%) than controls (29.7%) (p<0.05). A total placental lesion score of > or =3 was associated with an increased risk for IUGR (OR 14.18, 3.41-58.99; p<0.001) and increased risk for CUS abnormality (OR 12.571, 3.33-47.416; p<0.05). In a logistic regression model only > or =2 placental lesions, IUGR and gestational age <30 weeks were significant independent predictors of CUS abnormalities. CONCLUSIONS:The severity of placental abnormalities expressed as the cumulative number of placental lesions is a significant risk factor for IUGR and perinatal brain injury. These results suggest that abnormal uteroplacental or fetoplacental blood flow may adversely affect intrauterine growth and increase the risk for brain injury.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Viscardi RM,Sun CCdoi
10.1016/s0378-3782(01)00114-1keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
1-10issue
1eissn
0378-3782issn
1872-6232pii
S0378-3782(01)00114-1journal_volume
62pub_type
杂志文章abstract：:The essential fatty acid (EFA) composition of umbilical vessel walls is increasingly being studied as a longer-term reflection of the fetal EFA status. We evaluated the EFA content of umbilical artery and vein vessel walls in 43 preterm infants and compared it with that of 43 full-term cord vessels. In addition, relat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01656-n
更新日期：1995-08-18 00:00:00
abstract：BACKGROUND:Neonatal sepsis has been associated with poor neurodevelopmental outcome, however the evidence regarding the exact mechanism of the inflammation to the developing neonatal brain are inconclusive. AIMS:To investigate association between cerebral oxygenation during neonatal sepsis and neurodevelopmental outco...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.07.008
更新日期：2019-09-01 00:00:00
abstract：:We studied the ontogeny and temporal organization of non-nutritive sucking during active sleep in 6 healthy preterm infants (mean birthweight 1.1 kg (range 0.8-1.3 kg) gestational age 28.6 weeks (range 26-30 w] from 30 to 35 weeks of post-menstrual (PM) age. Recognizable rhythmical sucking bursts were recorded at 28 w...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90100-8
更新日期：1985-07-01 00:00:00
abstract：:More than 10,000 preterm babies worldwide have been enrolled in trials evaluating probiotics administration for the prevention of necrotising enterocolitis, with very few adverse events reported. Despite this, probiotic safety is frequently cited as a concern when using this intervention. This review addresses why a p...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2019.05.016
更新日期：2019-08-01 00:00:00
abstract：:White matter injury and abnormal maturation are thought to be major contributors to the neurodevelopmental disabilities observed in children and adolescents who were born preterm. Early detection of abnormal white matter maturation is important in the design of preventive, protective, and rehabilitative strategies for...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2008.09.004
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Long-lasting respiratory symptoms have a huge impact on the quality of life in prematurely born children. AIMS:We aimed to investigate the perinatal and maternal risk factors involved in the development of chronic respiratory morbidity in preterm infants, with an emphasis on the importance of Foetal Inflamm...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.07.002
更新日期：2014-09-01 00:00:00
abstract：:Nutrition has a key role in the modulation of the developing intestine in early infancy, and nutrients are able to modulate several intestinal functions including nutrient absorption, ion transport, cell growth and differentiation, motility and immunomodulation. Such modulation is exerted in part through a direct inte...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2010.01.008
更新日期：2010-07-01 00:00:00
abstract：:Breast- and formula-fed infants were compared with regard to behavior patterns, especially crying behavior. A diary concerning seven behaviors was completed by 188 mothers of breast- and formula-fed infants at the well baby clinic. Breast-fed infants were fed more frequently with longer feeding duration. They slept mo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00071-2
更新日期：2000-05-01 00:00:00
abstract：AIMS:To study longitudinal growth pattern of head circumference of full-term symmetric and asymmetric small for gestational age (SGA) infants of the two sexes during first year of life. STUDY DESIGN:Mixed-longitudinal growth research design. SUBJECTS:Head circumference amongst full-term 100 symmetric, 100 asymmetric ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.11.007
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Testosterone (T) is taken or prescribed to enhance appearance, increase athletic performance and libido and to treat hypogonadism. Digit ratio (2D:4D) is thought to be a negative correlate of prenatal T. Here we consider the relationship between 2D:4D and T supplementation. AIMS:Our sample was taken from th...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.104843
更新日期：2019-12-01 00:00:00
abstract：:Neonatal hyperglycaemia is a frequent complication in VLBW infants during the first week of life. The more common causes include high glucose intake, stress situations such as sepsis, NEC, and surgical treatments, as well as the administration of vasoactive drugs and methylxanthines. The appropriate definition is uncl...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2011.01.005
更新日期：2011-03-01 00:00:00
abstract：:Retinol-binding protein (RBP) and prealbumin (PA) are potentially useful indicators of inadequate protein and/or energy intake. Concentrations of RBP and PA were determined in cord blood of 117 infants and were found to be lower before 37 weeks gestation than at term. Adult subjects had substantially higher concentrat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90068-3
更新日期：1983-07-01 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease wi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90007-x
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:The kidney is one organ which presents distinct morphology depending on GA; the classic references for kidney measurements were established several years ago and it is not certain if they are still accurate. AIM:To evaluate the renal maturity using a computer-assisted morphometry in autopsied fetuses within...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.01.013
更新日期：2006-11-01 00:00:00
abstract：:No statistically significant relationships were observed between the red blood cell acid phosphatase polymorphism (ACP-1) and birth weight, duration of gestation and proportion of preterm infants in a large series of newborn infants (greater than 8000) in Cardiff. These results are contrasted with those of a similar, ...
journal_title：Early human development
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:It is convenient to calculate milk energy from the creamatocrit but in order to assess the accuracy with which energy content can be predicted in this way, the creamatocrit, the percentage of carbon, and the calorie value of milk were determined in 11 samples of pooled pasteurised human milk. The calculated milk energ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90121-5
更新日期：1985-05-01 00:00:00
abstract：:The relationship between blood glucose and body physique of 233 (42 hypo-and 191 normologycemic) intrauterine growth-retarded neonates was analyzed using different body measurements and indices of body proportions. Classification by combination of weight and length deficit for fetal age revealed that the disproportion...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(77)90027-5
更新日期：1977-10-01 00:00:00
abstract：BACKGROUND:Cases suggestive of non-acidemia related cerebral palsy (CP) are likely misdiagnosed as acidemia related CP because of the presence of nonreasuring fetal heart rate (FHR) patterns. AIMS:Our purpose was to compare intrapartum FHR patterns between the cases of neurological damage and the cases without disabil...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.10.007
更新日期：2009-04-01 00:00:00
abstract：:A cohort study was carried out to assess the association between glucose-6-phosphate dehydrogenase (G6PD) deficiency, diagnosed by quantitative enzyme assay, and neonatal hyperbilirubinemia, defined as serum total bilirubin >/=15 mg/dl, in the well-baby nursery of Chang Gung Children's Hospital. Among 42,110 inborn in...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(03)00002-1
更新日期：2003-04-01 00:00:00
abstract：:In the scholarly environment, research findings are disseminated as journal papers which support/dispute extant knowledge or add further to what is already known. The entire manuscript needs to be cited (in-text) and referenced (at the end of article), in order for readers to ascertain the validity of the research cla...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2018.09.012
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Respiratory syncytial virus (RSV) is a leading cause of hospitalization for children <1year old and is more severe in premature infants. OBJECTIVE:To assess whether late preterm (LPT) birth is an independent risk factor for RSV hospitalization and more severe RSV disease in children less than 24months old. ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.06.009
更新日期：2015-09-01 00:00:00
abstract：:Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90178-w
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVE:We hypothesized that morphine has a depressing effect on early brain activity, assessed using quantitative aEEG/EEG parameter and depressed activity will be associated with brain volumes at term in extremely preterm infants. STUDY DESIGN:174 preterm infants were enrolled in 3 European tertiary NICUs (mean GA...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.104970
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Carpal tunnel syndrome (CTS), a median nerve compressive neuropathy at the wrist, is the most common entrapment nerve disorder. Sex is an important risk factor of CTS as this condition is to five times more common in women than in men (sex-hormone dependent). There are no studies concerning 2D:4D (biomarker ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.104829
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To determine whether proportionate or disproportionate foetal smallness at 17 to 19 weeks of gestation in low-risk pregnancies was associated with size, body constitution, and adverse outcome at birth. METHODS:We included ultrasound measurements at 17-19 weeks of gestation in 7285 uncomplicated pregnancies w...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.01.010
更新日期：2006-10-01 00:00:00
abstract：:In the infant, sucking behaviour is one of the first coordinated muscular activities. It is under the control of the brainstem. In utero sucking is observed from 13 weeks' gestation. The healthy full-term newborn infant has a very stable rhythm of alternating bursts of sucking with pauses in between. The non-nutritive...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00091-8
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Small size at birth may be associated with impaired cognitive ability later in life. The aim of this study was to examine the effect of being born small for gestational age (SGA), with or without intrauterine growth restriction (IUGR) on cognitive ability in late adolescence. STUDY DESIGN:A follow-up study ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.08.014
更新日期：2015-12-01 00:00:00
abstract：:The aim is to know whether antenatal olfactory learning have a greater effect than postnatal olfactory learning on infant feeding even in the absence of triggering signals. We evaluated the sucking behavior of infants completely separated from their mothers for 10-14 days since birth. The 12 infants admitted to Chiba ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.10.003
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Mothers have been shown to have higher morning cortisol on days they go to work compared to non-workdays; however, it is unknown how maternal workday associates with child morning cortisol or the attunement of mother-child morning cortisol. AIMS:This study examined the presence and stability of morning cort...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.11.007
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the newborn transient evoked otoacoustic emission (TEOAE) hearing screening tests of infants later diagnosed with the sudden infant death syndrome (SIDS). STUDY DESIGN:In a case-controlled study, the newborn TEOAE hearing screens of 31 infants who subsequently died of SIDS were retrospectively co...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.06.001
更新日期：2008-04-01 00:00:00
