Abstract：
AIM:The effects of intestinal bifidobacteria on the development of immunity in early life were explored. METHODS:Neonatal SD rats born and housed under strict barrier systems were fed from birth with sufficient antibiotics (bifidobacteria minimisation group) or supplemented daily with 1x10(10) colony-forming units of live Bifidobacterium longum (bifidobacteria supplementation group). Relevant indices of immune development were determined at one, three and six weeks old. RESULTS:Compared to the control group, minimisation of the intestinal bifidobacteria delayed maturation of dendritic cells in Peyer's Patches and the development of T cells in the thymus, increased IL-4 secretion in the plasma, down-regulated IL-12, IL-10 mRNA and the interferon-gamma/IL-4 mRNA ratio in intestinal mucosa, decreased interferon-gamma mRNA in cultured peripheral blood mononuclear cells (PBMCs), and reduced immunoglobulin-M production in cultured PBMCs. Conversely, supplementation with bifidobacteria promoted dendritic cell maturation in Peyer's Patches, up-regulated IL-12, IL-10, interferon-gamma mRNA and the interferon-gamma/IL-4 ratio in intestinal mucosa, increased interferon-gamma gene expression in cultured PBMCs, and raised immunoglobulin-M secretion in cultured PBMCs. CONCLUSIONS:Intestinal bifidobacteria could promote the maturation of dendritic cells and its expression of IL-12 locally in the gut, influence the development of T cells in the thymus, favour the development of T-helper cell type 1 response by increasing the local and systemic expression of interferon-gamma and ensure the intestinal regulatory T cell response by promoting the local expression of IL-10. In addition, they enhance antibody synthesis by PBMCs, thereby affecting the development of both the gut and systemic immunity in early life.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Dong P,Yang Y,Wang WPdoi
10.1016/j.earlhumdev.2010.01.002subject
Has Abstractpub_date
2010-01-01 00:00:00pages
51-8issue
1eissn
0378-3782issn
1872-6232pii
S0378-3782(10)00004-6journal_volume
86pub_type
杂志文章abstract：:Mother's own milk is widely recognized as the optimal feeding for term infants, but also provides health benefits that are of vital importance for sick and preterm infants in neonatal intensive care units (NICUs), even though the growth and neurodevelopmental needs of very premature infants are best met by appropriate...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2013.07.008
更新日期：2013-10-01 00:00:00
abstract：:Eleven healthy fetuses between 36 and 39 weeks of gestation were studied during the active sleep state to examine effects of a 5-s vibratory acoustic stimulus on the baseline fetal heart rate and flow velocity waveform in the fetal internal carotid artery. There was an immediate marked rise in baseline fetal heart rat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90105-9
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:Physical and emotional parent-infant closeness activate important neurobiological mechanisms involved in parenting. In a neonatal care context, most research focuses on physical (parental presence, skin-to-skin contact) aspects; insights into emotional closeness can be masked by findings that overemphasise t...
journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The osmotic fragility of red blood cells reflects their membrane ability to maintain structural integrity. The osmolality at which the cells lyse is related to their shape, deformability, surface area/volume ratio and intrinsic membrane properties. In cord blood, there may be differences between premature an...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(03)00009-4
更新日期：2003-05-01 00:00:00
abstract：:The essential fatty acid (EFA) composition of umbilical vessel walls is increasingly being studied as a longer-term reflection of the fetal EFA status. We evaluated the EFA content of umbilical artery and vein vessel walls in 43 preterm infants and compared it with that of 43 full-term cord vessels. In addition, relat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01656-n
更新日期：1995-08-18 00:00:00
abstract：:To evaluate the association of acute and common chronic diseases, alcohol consumption and smoking during pregnancy with reduction limb defects (RLD) 453 cases of RLD from the Finnish Registry of Congenital Malformations were studied. RLD cases without additional malformations were analyzed separately. Statistical asso...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90101-9
更新日期：1983-12-01 00:00:00
abstract：INTRODUCTION:The 2D:4D digit ratio is sexually-dimorphic, probably due to testosterone action through the perinatal period. We characterize the 2D:4D ratio in newborn (NB) infants, in between the pre- and postnatal surges of testosterone, and relate it to the mother's 2D:4D and to testosterone levels in the amniotic fl...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.08.009
更新日期：2013-02-01 00:00:00
abstract：:Hepatic glucose production by glycogenolysis and gluconeogenesis is essential to maintain blood glucose levels, and the glucose-6-phosphatase system catalyses the terminal step of both pathways. Developmental delays in the postnatal up-regulation of hepatic glucose-6-phosphatase enzyme activity are common in preterm i...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.10.005
更新日期：2005-01-01 00:00:00
abstract：:Altogether 2159 pregnancies among black and white Americans in the Collaborative Perinatal Study and dental casts from the children at the age of 5-12 years were studied to find out the effect of maternal smoking on deciduous tooth crown growth. Minor crown size reduction (2-3%) in some dimensions was found in childre...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90086-v
更新日期：1992-08-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.02.001
更新日期：2006-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.10.014
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The sudden infant death syndrome (SIDS) is still the main cause of postneonatal infant death and its cause is still unknown. Recently, the medullary serotonergic network deficiency theory has been proposed and an association between SIDS and neuronal plasticity has also been suggested. The growth-associated ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.08.017
更新日期：2003-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(79)90042-2
更新日期：1979-12-01 00:00:00
abstract：:Apnea of prematurity and gastroesophageal reflux (GER) are both common occurrences in preterm infants and widely perceived to be causally related. We seek in this review to provide a potential guideline for neonatal GER non-pharmacologic and pharmacologic therapy. Available physiologic data suggest that when there is ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(13)70005-7
更新日期：2013-06-01 00:00:00
abstract：:Cardiovascular malformations are frequently associated in patients with esophageal atresia (EA). We observed azygos continuation mimicking an aortic arch anomaly in four newborns with type III EA. They presented concomitant rib anomalies indicating a common developmental defect. Foreknowledge is important for planning...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2017.05.007
更新日期：2017-08-01 00:00:00
abstract：:Retinol-binding protein (RBP) and prealbumin (PA) are potentially useful indicators of inadequate protein and/or energy intake. Concentrations of RBP and PA were determined in cord blood of 117 infants and were found to be lower before 37 weeks gestation than at term. Adult subjects had substantially higher concentrat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90068-3
更新日期：1983-07-01 00:00:00
abstract：:Prevention of extra-uterine growth retardation is of extreme importance, as the achievement of adequate growth has been associated with a favorable neurodevelopmental outcome through childhood. In addition, as disturbances in growth that take place early in life may affect adult health, a full understanding of the gro...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2013.08.004
更新日期：2013-10-01 00:00:00
abstract：:This project aimed to assess the accuracy of Tempa-DOT and FeverScan for measuring children's temperatures. Tempa-DOT is a small flat chemical thermometer with 50 dots that change colour at specific temperatures. FeverScan is a liquid crystal strip thermometer with temperature sensitive colour bars that change colour ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00050-4
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Bright constant light levels in the NICU may have negative effects on the growth and development of preterm infants OBJECTIVE:The aim of this study is to evaluate the benefits of an alternating light/dark cycle in the NICU on weight gain and early discharge from the therapy in premature infants. PATIENTS A...
journal_title：Early human development
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.earlhumdev.2014.04.015
更新日期：2014-09-01 00:00:00
abstract：:Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00077-2
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Testosterone (T) is taken or prescribed to enhance appearance, increase athletic performance and libido and to treat hypogonadism. Digit ratio (2D:4D) is thought to be a negative correlate of prenatal T. Here we consider the relationship between 2D:4D and T supplementation. AIMS:Our sample was taken from th...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.104843
更新日期：2019-12-01 00:00:00
abstract：:Dexamethasone (DEX), a synthetic glucocorticoid, has been widely used to prevent the development of a variety of poor health conditions in premature infants including chronic lung disease, inflammation, circulatory failure, and shock. Although there are some reports of neurologic complications related to DEX exposure,...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.10.007
更新日期：2013-05-01 00:00:00
abstract：:Long-term respiratory morbidity is common, particularly in those born very prematurely and who have developed bronchopulmonary dysplasia (BPD), but it does occur in those without BPD and in infants born at term. A variety of neonatal strategies have been developed, all with short-term advantages, but meta-analyses of ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2014.08.020
更新日期：2014-11-01 00:00:00
abstract：:Cardiorespiratory interactions in healthy full term newborns were investigated. Spectral analysis was used on heart rate and breathing data from 22 neonates 2-5 days old to reveal coincident frequencies in the breathing and heart rate variability (HRV) spectra, thus identifying respiratory sinus arrhythmia (RSA). The ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90197-3
更新日期：1993-01-01 00:00:00
abstract：:A cohort study was carried out to assess the association between glucose-6-phosphate dehydrogenase (G6PD) deficiency, diagnosed by quantitative enzyme assay, and neonatal hyperbilirubinemia, defined as serum total bilirubin >/=15 mg/dl, in the well-baby nursery of Chang Gung Children's Hospital. Among 42,110 inborn in...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(03)00002-1
更新日期：2003-04-01 00:00:00
abstract：UNLABELLED:During the previous two decades smoking among pregnant women in the developed world declined by about 60-75%. Nevertheless, prenatal smoking remains a common habit and accounts for a significant proportion of fetal morbidity and mortality through both a direct (fetal) and an indirect (placental) effect. The ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2007.08.002
更新日期：2007-11-01 00:00:00
abstract：:Psychobiological studies of fetal ontogenesis in non-human species, particularly in laboratory rat, now have much to offer students of human development. Psychobiological approaches are 'ecologically' oriented which, for fetal research, implies consideration of the adaptive significance of behavior within the uterine ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/0378-3782(93)90102-z
更新日期：1993-12-31 00:00:00
abstract：:Unexpected death in infancy may be a consequence of recognisable pathophysiological processes, or may remain unexplained after thorough investigation. We review the appropriate investigations that should be performed after unexpected infant deaths, and the recent changes to UK law that will make such investigations ma...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2006.09.012
更新日期：2006-12-01 00:00:00
abstract：:Posture and spontaneous motor patterns during the first days of life were studied in ten healthy fullterm infants by direct observation and videorecording. The aim of the study was to provide a description of motor and postural characteristics of normal newborns. The infants were recorded for 1 h on their first and fo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90020-0
更新日期：1989-02-01 00:00:00
abstract：BACKGROUND:Non-nutritive suck (NNS) is one piece of the complex oral feeding process, yet there is paucity on how it develops throughout the first year of life. AIMS:To determine changes in infant NNS between 3 and 12 months of age. STUDY DESIGN:Twenty-six full-term infants (65% male) completed this study. All infant...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105141
更新日期：2020-10-01 00:00:00
