当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Effect of raloxifene, 17beta-estradiol, and progesterone on mRNA for vascular endothelial growth factor isoforms 121 and 165 and thrombospondin-1 in Ishikawa cells.

Effect of raloxifene, 17beta-estradiol, and progesterone on mRNA for vascular endothelial growth factor isoforms 121 and 165 and thrombospondin-1 in Ishikawa cells.

Abstract：

OBJECTIVE:To compare the mRNA expression of vascular endothelial growth factor (VEGF) 121 and 165 isoforms and thrombospondin-1 (TSP-1) after raloxifene, 17beta-E(2), and P administration in cultured Ishikawa cells. DESIGN:Prospective basic research study. SETTING:Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia. PATIENT(S):None. INTERVENTION(S):Ishikawa cells were cultured in vitro. Raloxifene, 17beta-E(2), and P at concentrations of 0.01, 0.1, and 1.0 microM were added to confluent cells. MAIN OUTCOME MEASURES:The VEGF 121 and 165 isoforms and TSP-1 mRNA expression from treated Ishikawa cells were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). RESULT(S):17beta-Estradiol increased both VEGF 121 and 165 mRNA compared to control. Raloxifene did not increase either VEGF 121 or 165 mRNA above control values. Progesterone at all concentrations did not increase VEGF 121 isoform mRNA, whereas VEGF 165 isoform was minimally increased by P at the lowest concentration. Progesterone and raloxifene increased TSP-1 mRNA expression. 17beta-Estradiol did not stimulate TSP-1 mRNA expression at any concentration. CONCLUSION(S):Raloxifene did not stimulate VEGF 121 and 165, whereas it increased TSP-1 mRNA synthesis in Ishikawa cells. Our hypothesis is that raloxifene's lack of endometrial stimulation may be partly mediated by an antiangiogenic effect.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Navarro FJ,Mirkin S,Archer DF

doi

10.1016/s0015-0282(03)00350-9

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

1409-15

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015028203003509

journal_volume

79

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Androgen effects on bone and muscle.

    abstract：:Bone health and strength are dependent on the coupling of cone resorption and bone formation. This process is governed by the interaction of osteoclasts and osteoblasts plus the modulating influence of the bone mechanicosensory cells-the osteocytes. Both sex steroids-estrogen (E) and testosterone (T)- have receptors o...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/s0015-0282(02)02968-0

    authors： Notelovitz M

    更新日期：2002-04-01 00:00:00

  • Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking.

    abstract：OBJECTIVE:To evaluate the efficiency of oocyte donation cycles using egg "cryo-banking." DESIGN:Study conditions for vitrified/warmed oocytes for 20 non-autologous recipients (from 10 donors) were set prospectively, and outcomes of it were later compared retrospectively to nine fresh donations cycles. SETTING:Private...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2008.06.005

    authors： Nagy ZP,Chang CC,Shapiro DB,Bernal DP,Elsner CW,Mitchell-Leef D,Toledo AA,Kort HI

    更新日期：2009-08-01 00:00:00

  • Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation.

    abstract：OBJECTIVE:To evaluate the impact of carrying a BRCA1 or BRCA2 mutation on the probability of experiencing premature natural menopause. DESIGN:Observational study. SETTING:Patients in an academic research environment. PATIENT(S):Women who carry a BRCA1 or BRCA2 mutation (case subjects) and women who do not carry a mu...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.fertnstert.2013.01.109

    authors： Finch A,Valentini A,Greenblatt E,Lynch HT,Ghadirian P,Armel S,Neuhausen SL,Kim-Sing C,Tung N,Karlan B,Foulkes WD,Sun P,Narod S,Hereditary Breast Cancer Study Group.

    更新日期：2013-05-01 00:00:00

  • Assessment of FSHR variants and antimüllerian hormone in infertility patients with a reduced ovarian response to gonadotropin stimulation.

    abstract：OBJECTIVE:To study women with a poor response to ovarian hormone stimulation, known as low responders. Genetic defects in the FSH receptor gene (FSHR) were analyzed as well as antimüllerian hormone (AMH) for ovarian reserve. DESIGN:Retrospective cohort study. SETTING:University hospital. PATIENT(S):Two hundred fifty...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.02.012

    authors： Binder H,Strick R,Zaherdoust O,Dittrich R,Hamori M,Beckmann MW,Oppelt PG

    更新日期：2012-05-01 00:00:00

  • Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and increased expression of CD44 splice variants.

    abstract：OBJECTIVE:We previously demonstrated that adherence of endometrial epithelial (EECs) and stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) is partly regulated by ESC/EEC CD44 interactions with PMC associated hyaluronan. CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice va...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.12.012

    authors： Griffith JS,Liu YG,Tekmal RR,Binkley PA,Holden AE,Schenken RS

    更新日期：2010-04-01 00:00:00

  • Autoantibodies to markers of oxidative stress are elevated in women with endometriosis.

    abstract：OBJECTIVE:To measure autoantibodies that recognize oxidatively modified proteins in the sera of women with surgically proven endometriosis. DESIGN:Prospective study. SETTING:Tertiary care academic medical center. PATIENT(S):Women undergoing surgery for endometriosis or tubal ligation. INTERVENTION(S):None. MAIN OU...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(99)00145-4

    authors： Shanti A,Santanam N,Morales AJ,Parthasarathy S,Murphy AA

    更新日期：1999-06-01 00:00:00

  • Lack of standardization in performance of the semen analysis among laboratories in the United States.

    abstract：OBJECTIVE:To determine the level of standardization in performance of the semen analysis among clinical laboratories in the United States. DESIGN:A survey was mailed to laboratories requesting information about the laboratory and performance of the semen analysis. Responses were received from 536 laboratories. SETTIN...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)03296-x

    authors： Keel BA,Stembridge TW,Pineda G,Serafy NT Sr

    更新日期：2002-09-01 00:00:00

  • The impairment of reproduction in db/db mice is not mediated by intraovarian defective leptin signaling.

    abstract：OBJECTIVE:To demonstrate whether leptin modulates reproduction by a direct effect within the ovary. DESIGN:Animal model. SETTING:National Key Laboratory of Infertility. ANIMAL(S):Adult female db/db mice. INTERVENTION(S):Adult littermate wild-type (WT) and diabetic (db) leptin receptor (LR) mutant female mice were m...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.01.126

    authors： Zhang Y,Hu M,Ma H,Qu J,Wang Y,Hou L,Liu L,Wu XK

    更新日期：2012-05-01 00:00:00

  • Return of gonadotropic function in postpartum women during bromocriptine treatment.

    abstract：:The rapid postpartum return of gonadotropic function during bromocriptine treatment was investigated through hormonal measurements in 15 women. Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG). Prolactin was effectively suppressed by ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60610-6

    authors： Kremer JA,Rolland R,van der Heijden PF,Thomas CM,Lancranjan I

    更新日期：1989-04-01 00:00:00

  • Frozen-thawed day 5 blastocyst transfer is associated with a lower risk of ectopic pregnancy than day 3 transfer and fresh transfer.

    abstract：OBJECTIVE:To determine the ectopic pregnancy rate with fresh versus frozen-thawed embryo transfers, and factors associated with ectopic pregnancy in patients undergoing IVF-ET. DESIGN:Retrospective analysis. SETTING:Institutional IVF center. PATIENT(S):A total of 3,183 patients who received 3,340 blastocysts transfe...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2014.11.023

    authors： Fang C,Huang R,Wei LN,Jia L

    更新日期：2015-03-01 00:00:00

  • Interleukin-8 gene and protein expression are up-regulated by interleukin-1beta in normal human ovarian cells and a granulosa tumor cell line.

    abstract：OBJECTIVE:To evaluate the expression, regulation, and role of interleukin (IL)-8 in human ovary. DESIGN:Prospective study. SETTING:University hospital. PATIENT(S):Sixteen premenopausal women. INTERVENTION:Follicular fluid and granulosa lutein cells (GLCs) were collected during IVF cycles. Ovarian stromal and theca ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)04408-4

    authors： Fujii A,Harada T,Yamauchi N,Iwabe T,Nishi Y,Yanase T,Nawata H,Terakawa N

    更新日期：2003-01-01 00:00:00

  • Next-generation sequencing reveals differentially expressed small noncoding RNAs in uterine leiomyoma.

    abstract：OBJECTIVE:To determine the expression profile of small noncoding RNAs (sncRNAs) in leiomyoma, which has not been investigated to date. DESIGN:Laboratory-based investigation. SETTING:Academic center. PATIENT(S):Women undergoing hysterectomy for benign indications. INTERVENTION(S):Next-generation sequencing and scree...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2018.01.034

    authors： Chuang TD,Xie Y,Yan W,Khorram O

    更新日期：2018-05-01 00:00:00

  • Immunoneutralization of gonadotropin-releasing hormone and subsequent treatment with testosterone Silastic implants in rats: an approach toward developing a male contraceptive.

    abstract：STUDY OBJECTIVE:To determine the extent to which increasing doses of exogenous testosterone (T) administered via Silastic implants can restore spermatogenesis and fertility to rats made azoospermic by active immunization against gonadotropin-releasing hormone (GnRH). DESIGN:Male rats were made azoospermic by active im...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)55192-9

    authors： Awoniyi CA,Kim WK,Hurst BS,Schlaff WD

    更新日期：1992-08-01 00:00:00

  • Functional differentiation in progesterone secretion by granulosa versus cumulus cells in the human preovulatory follicle and the effect of different induction of ovulation protocols.

    abstract：OBJECTIVE:To investigate P secretion by granulosa cells (GCs) versus cumulus cells derived from human preovulatory follicles. DESIGN:Cells were recovered by aspiration of preovulatory follicles in 44 women participating in an IVF program. Induction of ovulation was performed using clomiphene citrate, hMG and hCG (grou...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56404-8

    authors： Dirnfeld M,Goldman S,Gonen Y,Koifman M,Lissak A,Kraiem Z,Abramovici H

    更新日期：1993-12-01 00:00:00

  • Development and integration of an extended embryo culture program.

    abstract：OBJECTIVE:To study and evaluate a sequential, extended embryo culture system. DESIGN:Prospective study. SETTING:University-affiliated IVF clinic. PATIENT(S):All couples who were treated between October 1997 and July 1998. INTERVENTION(S):A standard human tubal fluid plus 10% serum substitute supplement (SSS) cultur...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(99)00294-0

    authors： Patton PE,Sadler-Fredd K,Burry KA,Gorrill MJ,Johnson A,Larson JM,Wolf DP

    更新日期：1999-09-01 00:00:00

  • Occupation and the follow-up of infertile couples.

    abstract：OBJECTIVE:To evaluate the influence of socioeconomic factors on the outcomes of infertility, including pregnancy, adoption, resolution, and loss to follow-up. DESIGN:Prospective observational study. SETTING:Infertility clinics in 11 teaching hospitals. PATIENTS:Newly registered couples with infertility of > 1 year. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Collins JA,Burrows EA,Willan AR

    更新日期：1993-09-01 00:00:00

  • Novel dynamic culture system to support initiation of primordial follicle growth in prepubertal mouse ovaries.

    abstract：OBJECTIVE:To evaluate the impact of dynamic in vitro culture on initiation of early follicular growth in prepubertal mouse ovaries. DESIGN:Ovaries from 8-day-old BALB/c mice were cultured either in a dynamic system (n=28) or in a static system (n=20) for 4 days. Uncultured 8-day-old (n=9) or 12-day-old (n=17) ovaries ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2014.05.038

    authors： Winkler-Crepaz K,Nederegger V,Ayuandari S,Rosenfellner D,Zervomanolakis I,Hofer S,Wildt L,Ziehr SC

    更新日期：2014-09-01 00:00:00

  • Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the azoospermic subject.

    abstract：OBJECTIVE:To investigate whether testicular cytology by fine needle aspiration (FNA) may be considered a diagnostic parameter in the evaluation of the azoospermic subject. DESIGN:Cytologic smears were obtained using a 23-G needle, stained with May-Grünwald-Giemsa stain and examined under a light Orthoplan microscope (...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54971-1

    authors： Foresta C,Varotto A,Scandellari C

    更新日期：1992-04-01 00:00:00

  • Combination of metabolism measurement and a time-lapse system provides an embryo selection method based on oxygen uptake and chronology of cytokinesis timing.

    abstract：OBJECTIVE:To evaluate correlations between oxygen consumption (OC) measurements before and after embryo cytokinesis, observing OC during embryo cleavages and combining that information with morphokinetics to relate to implantation potential. DESIGN:Prospective cohort study. SETTING:University-affiliated private IVF u...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.03.019

    authors： Tejera A,Castelló D,de Los Santos JM,Pellicer A,Remohí J,Meseguer M

    更新日期：2016-07-01 00:00:00

  • Freeze-all policy: fresh vs. frozen-thawed embryo transfer.

    abstract：OBJECTIVE:To compare in vitro fertilization (IVF) outcomes between fresh embryo transfer (ET) and frozen-thawed ET (the "freeze-all" policy), with fresh ET performed only in cases without progesterone (P) elevation. DESIGN:Prospective, observational, cohort study. SETTING:Private IVF center. PATIENT(S):A total of 53...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.01.045

    authors： Roque M,Valle M,Guimarães F,Sampaio M,Geber S

    更新日期：2015-05-01 00:00:00

  • Buoyant density and sedimentation dynamics of HIV-1 in two density-gradient media for semen processing.

    abstract：OBJECTIVE:To compare buoyant density and sedimentation kinetics of human immunodeficiency virus 1 (HIV-1) in two sperm-washing media, Percoll and Pureception. DESIGN:Laboratory study. SETTING:University hospital. PATIENT(S):None. INTERVENTION(S):Buoyant density and sedimentation kinetics of HIV-1 particles (MOLT-4/...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.09.025

    authors： Kuji N,Yoshii T,Hamatani T,Hanabusa H,Yoshimura Y,Kato S

    更新日期：2008-11-01 00:00:00

  • Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies.

    abstract：OBJECTIVE:To study the controversial association between human leukocyte antigen-G (HLA-G) 14 bp polymorphism and recurrent pregnancy loss (RPL). We performed a meta-analysis of studies in the literature that enrolled only women of European countries who experienced RPL spontaneously or after undergoing IVF. DESIGN:Sy...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.fertnstert.2019.05.003

    authors： Monti M,Lupoli R,Sosa Fernandez LM,Cirillo F,Di Minno MND

    更新日期：2019-09-01 00:00:00

  • Clinical outcome of using ganirelix acetate versus a 4-day follicular phase leuprolide acetate protocol in unselected women undergoing in vitro fertilization.

    abstract：OBJECTIVE:To compare the clinical outcome of controlled ovarian hyperstimulation (COH) in unselected patients undergoing IVF using multidose ganirelix acetate versus 4 days of administration of leuprolide acetate. DESIGN:Retrospective cohort study. SETTING:A fertility and IVF center. PATIENT(S):Two hundred forty-sev...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(03)00500-4

    authors： Posada MN,Vlahos NP,Jurema MW,Bracero NJ,Wallach EE,Garcia JE

    更新日期：2003-07-01 00:00:00

  • Occupationally related exposures and reduced semen quality: a case-control study.

    abstract：OBJECTIVE:To determine whether there is an association between abnormal semen parameters and occupational exposures to organic solvents, metals, and pesticides. DESIGN:Case-control study using three case groups based on different cutoff values for semen parameters and one standard reference group. SETTING:University ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(98)00542-1

    authors： Tielemans E,Burdorf A,te Velde ER,Weber RF,van Kooij RJ,Veulemans H,Heederik DJ

    更新日期：1999-04-01 00:00:00

  • Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?

    abstract：OBJECTIVE:To evaluate the effects of a prolonged duration of gonadotropin-releasing hormone agonist (GnRH-a) in pituitary down-regulation for controlled ovarian hyperstimulation (COH) on the live-birth rate in nonendometriotic women undergoing in vitro fertilization and embryo transfer (IVF-ET). DESIGN:Retrospective c...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2014.03.030

    authors： Ren J,Sha A,Han D,Li P,Geng J,Ma C

    更新日期：2014-07-01 00:00:00

  • Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer.

    abstract：OBJECTIVE:To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis. DESIGN:Retrospective cohort study. SETTING:University-based infertility center, January 1998 to June 2006. PATIENT(S):Two hundred eighteen IVF pregnancie...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.05.049

    authors： Kansal Kalra S,Ratcliffe SJ,Milman L,Gracia CR,Coutifaris C,Barnhart KT

    更新日期：2011-02-01 00:00:00

  • Role of blood and fibrinogen in development of intraperitoneal adhesions in rats.

    abstract：:One hundred and twenty rats were divided into six groups and laparotomized. In three of the groups the cecum was left intact. In one of these groups the cecum was only lifted up through the abdominal incision and then replaced in the abdominal cavity. In another group the intact cecum was bathed with a certain amount ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)43584-3

    authors： Nisell H,Larsson B

    更新日期：1978-10-01 00:00:00

  • Subcutaneously administered Repronex in female patients undergoing in vitro fertilization is as effective and well tolerated as intramuscular menotropin treatment. Repronex SC, IVF Study Group.

    abstract：OBJECTIVE:To determine the efficacy and safety of Repronex SC as compared with Repronex IM and Pergonal IM in patients undergoing IVF. DESIGN:Open-label, randomized, parallel-group, multicenter study. SETTING:Fifteen academic and private fertility clinics with IVF experience. PATIENT(S):Premenopausal women with regu...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0015-0282(00)00605-1

    authors： Gocial B,Keye WR,Fein SH,Nardi RV

    更新日期：2000-07-01 00:00:00

  • Effects of tumor necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment.

    abstract：OBJECTIVE:To evaluate the effects of tumor necrosis factor-alpha (TNF-alpha) on porcine oocyte maturation, spindle dynamics, and chromosome alignment. DESIGN:Controlled, prospective study. SETTING:University hospital and IVF research laboratory. ANIMAL(S):Ovaries collected from slaughtered prepubertal gilts. MAIN O...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.01.131

    authors： Ma CH,Yan LY,Qiao J,Sha W,Li L,Chen Y,Sun QY

    更新日期：2010-02-01 00:00:00

  • Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis.

    abstract：OBJECTIVE:To analyze the role of the local renin-angiotensin system (RAS) in the female reproductive system to modulate ovarian steroidogenesis and its relationship with alpha(1)adrenergic receptors. DESIGN:Observational study. SETTING:University laboratory. ANIMAL(S):Adult female Wistar rats treated with doxazosin ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.12.021

    authors： de la Chica-Rodríguez S,Cortés-Denia P,Ramírez-Expósito MJ,de Saavedra JM,Sánchez-Agesta R,Pérez Mdel C,Martínez-Martos JM

    更新日期：2007-10-01 00:00:00