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Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis.

Abstract：

OBJECTIVE:To analyze the role of the local renin-angiotensin system (RAS) in the female reproductive system to modulate ovarian steroidogenesis and its relationship with alpha(1)adrenergic receptors. DESIGN:Observational study. SETTING:University laboratory. ANIMAL(S):Adult female Wistar rats treated with doxazosin (10 mg/kg) or vehicle for 15 days. INTERVENTION(S):Samples from the whole right ovary were dissected after perfusion with saline. The soluble and membrane-bound fractions were obtained from these samples. Also, blood samples were used to obtain the serum. MAIN OUTCOME MEASURE(S):Fluorometric measurement of soluble and membrane-bound RAS-regulating proteolytic regulatory enzyme activities by using arylamide derivatives as substrates. Time-resolved fluoroimmunoassay of serum E(2) and P. RESULT(S):alpha(1)Adrenergic receptor blockade increases ovarian soluble and membrane-bound aminopeptidase A and decreases membrane-bound aminopeptidase N and aminopeptidase B. Furthermore, serum P levels increased, whereas serum E(2) did not change. CONCLUSION(S):Ovarian P production, at least in the rat, is regulated by noradrenaline through a mechanism of action in which the RAS is involved, with a main role for angiotensin III.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

de la Chica-Rodríguez S,Cortés-Denia P,Ramírez-Expósito MJ,de Saavedra JM,Sánchez-Agesta R,Pérez Mdel C,Martínez-Martos JM

doi

10.1016/j.fertnstert.2006.12.021

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1071-5

issue

4 Suppl

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)00047-7

journal_volume

88

pub_type

杂志文章

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