Abstract:
:To compare the effects of testosterone (T) and dihydrotestosterone (DHT) on the maintenance and the restoration of spermatogenesis, hypophysectomized (APX) rats were treated daily for 35 days with 0.5 mg of T propionate (TP) or DHT propionate (DHTP) beginning 5 or 33 days after hypophysectomy. In the maintenance experiment, the weights of the testes and the number of early spermatids were significantly lower in DHTP-than in TP-treated animals, while late spermatids were present only in rats treated with TP. In the restoration experiment, TP increased testicular weight and the number of germinal cells, whereas DHTP had very little effect on the testis. In an attempt to explain these findings, we measured androgen levels in the rete testis fluid (RTF) and peripheral plasma of APX rats treated with TP or DHTP. The concentration of T in the RTF of TP-treated rats was nearly 3-fold higher than the level of DHT in the RTF of animals given DHTP. Plasma T levels measured 1/2, 2, 4, and 24 hours after the last of three daily injections of TP were considerably higher than were the corresponding plasma DHT levels in animals given DHTP. In animals treated with free steroids, peripheral androgen levels between 1/2 and 4 hours after the last injection were much higher in rats given T than in those given DHT, but thereafter this difference disappeared. We conclude that the difference in the ability of subcutaneously injected TP and DHTP to maintain and to restore spermatogenesis in APX rats was due to a difference in androgen levels in the testes of these animals.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Harris ME,Bartke A,Weisz J,Watson Ddoi
10.1016/s0015-0282(16)42865-7subject
Has Abstractpub_date
1977-10-01 00:00:00pages
1113-7issue
10eissn
0015-0282issn
1556-5653pii
S0015-0282(16)42865-7journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:To compare the rate of ectopic pregnancy (EP) with fresh versus frozen blastocyst transfer in our program during the same time period. DESIGN:Retrospective analysis. SETTING:University IVF program. PATIENT(S):Women who achieved a clinical pregnancy after IVF between 1998 and 2005. INTERVENTION(S):In our p...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.005
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To quantify the risk of recurrent early pregnancy loss in the presence of elevated fasting or afterload homocysteine concentrations or homozygosity for the 677C-->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (T/T genotype). DESIGN:Case-control studies published between January 1992 and ...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/s0015-0282(00)01595-8
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether temporarily withholding FSH and adding androgen could improve follicular response during a microdose flare protocol in women with slow follicular growth or asynchronous follicular development. DESIGN:Observational pilot study. SETTING:University-affiliated private fertility center. P...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.038
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the plasma asymmetric dimethyl arginine (ADMA) levels and carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS). DESIGN:Prospective study. SETTING:University medical center. PATIENT(S):Thirty-five patients with PCOS and 31 healthy controls. INTERVENTION(S):Peri...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.10.073
更新日期:2010-03-01 00:00:00
abstract::Genetic factors, especially numerical chromosome anomalies, play an important role in embryonic loss. Because somatic cell analysis cannot assess the risk of errors arising de novo during germ cell maturation, we investigated whether the male gametes from couples with habitual abortion carry a higher rate of anomalies...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54505-1
更新日期:1991-08-01 00:00:00
abstract::A case of coma due to embolization after HSG, using oil-soluble contrast medium is presented. The patient was in a comatose state 11 days and then spontaneously regained full consciousness. The safety of oil-contrast medium for HSG is questionable. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53537-7
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of coital lubricants and oils on sperm motility. DESIGN:Comparative prospective in vitro study. SETTING:University Andrology laboratory. PATIENT(S):Twenty-two normozoospermic donors. INTERVENTION(S):Semen samples were incubated in modified human tubal fluid (mHTF) control and in 10...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.12.024
更新日期:2014-04-01 00:00:00
abstract::In the early years of in vitro fertilization, overall pregnancy rates were low, and it was considered necessary to transfer more than one embryo to increase the chances of pregnancy. It was not until advances in assisted reproductive technologies resulting in increased pregnancy rates that the concept of transferring ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2020.09.003
更新日期:2020-10-01 00:00:00
abstract::The serum levels of bioactive luteinizing hormone (LH), immunoreactive LH, follicle-stimulating hormone, androstenedione (A), and testosterone (T) were determined in nine anovulatory women with polycystic ovarian syndrome (PCOS) before and after laparoscopic ovarian cautery. Eight ovulated spontaneously and three conc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53451-7
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To describe a 5-year experience of fluoroscopically guided hysteroscopic synechiolysis for Asherman's syndrome. DESIGN:Retrospective, uncontrolled cohort study. SETTING:Department of Endo-Gynaecology, University of New South Wales, Royal Hospital for Women, Randwick, Sydney, New South Wales, Australia. PAT...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.06.035
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To compare androgen responses during ACTH infusion among women with polycystic ovary syndrome (PCOS) and healthy women. DESIGN:Cross-sectional study. SETTING:Academic medical center. PATIENT(S):Women with PCOS (n = 13) and healthy controls (n = 15). INTERVENTION(S):Blood samples were obtained frequently d...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.06.039
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of estrogen replacement therapy (ERT) on laryngeal cytology in postmenopausal women. DESIGN:Prospective open clinical trial. SETTING:Outpatient menopausal clinic in the Department of Gynecology, University of Catania, Catania, Italy. PATIENT(S):Eighty-four healthy, surgically pos...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(00)01582-x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To determine the regulatory role of hCG on P secretion in normal and abnormal (abortive and ectopic) first trimester pregnancies. STUDY DESIGN:The number of doublings of hCG per day (1/DT; reciprocal of hCG doubling time) was correlated with serum P using linear and nonlinear models in normal intrauterine pr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56876-9
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To compare the euploidy outcome in patients that underwent 2 ovarian stimulation cycles with trophectoderm biopsy. DESIGN:Retrospective repeated-measures cohort study. SETTING:University-based fertility center. PATIENT(S):A total of 116 patients, from 2011 through 2013, that underwent 2 ovarian stimulation...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.12.126
更新日期:2015-04-01 00:00:00
abstract::Many women now choose to develop their careers before having children. Thus, it is becoming increasingly important to assess a woman's potential for extended fertility and to understand the health consequences of having children at a late age. In particular, there is a striking positive correlation between extended fe...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2015.02.008
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To assess the capacity of human frozen-thawed ovarian follicles matured in xenografts to form metaphase II (MII) oocytes after xenotransplantation and exogenous stimulation. DESIGN:Prospective controlled animal study. SETTING:University hospital gynecology research unit. PATIENT(S):Ovarian fragments were o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.01.038
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To study the effects of peritoneal macrophages on endometrial cellular proliferation in an in vitro coculture model and to compare the magnitude of these effects between macrophages from women with endometriosis and normal women. DESIGN:Controlled study of peritoneal macrophage function. SETTING:University ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00292-7
更新日期:1999-09-01 00:00:00
abstract::This study fails to uphold the concept of invisible, microscopic endometriosis. Peritoneum devoid of disease exists, can be described, and can be consistently found. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60205-4
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that during the luteal phase of the ovarian cycle, as compared with the follicular phase, the peripheral immune response is shifted toward a type-2 response. DESIGN:Prospective study. SETTING:Academic research setting. PATIENT(S):Women with regular menstrual cycles. INTERVENTION(S):...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)01553-3
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively the effects of high-dose, short-term treatment with a glucocorticoid in an attempt to normalize ovarian failure and induce pregnancy in women presenting with infertility. DESIGN:Uncontrolled, nonrandomized prospective study. SETTING:Two university-based reproductive endocrinology c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55915-9
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To assess the use and effectiveness of IVF in a cohort of women undergoing surgery for endometriosis. DESIGN:Cohort study. SETTING:University hospital. PATIENT(S):Four hundred thirty-eight patients who attempted to become pregnant after conservative surgery for endometriosis. INTERVENTION(S):Interview. M...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.02.004
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of intracytoplasmic sperm injection (ICSI) and assisted hatching (AH) on assisted reproductive technology (ART) outcomes in initial cycles with diminished ovarian reserve (DOR) as the primary diagnosis. DESIGN:Retrospective cohort study of cycles from the Society for Assisted Reprod...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.06.043
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether the embryotoxic effect of peritoneal fluid (PF) from infertile women with mild endometriosis on mouse oocytes and embryos is associated with changes in embryonic epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and their receptors. DESIGN:Experimental animal study. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.11.011
更新日期:2010-05-15 00:00:00
abstract::Women bear the predominant burden of our obesogenic environment, with a higher incidence of obesity than men, more impact on their fertility and success with treatment, and significant maternal and perinatal morbidity and mortality. In this series, the causes, consequences, and solutions regarding the obesity pandemic...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2017.02.110
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of estrogen and progestogen on the resistance to blood flow in the uterine arteries of Turner's syndrome patients. DESIGN:Prospective clinical study. SETTING:A tertiary infertility clinic. PATIENTS:Five Turner's syndrome patients, six patients who had surgical castration, and five...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57968-0
更新日期:1995-12-01 00:00:00
abstract::Based on American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology data available for 2010, ASRM's guidelines for the number of embryos to be transferred in in vitro fertilization cycles have been further refined in continuing efforts to reduce the number of higher-order multip...
journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引
doi:10.1016/j.fertnstert.2012.09.038
更新日期:2013-01-01 00:00:00
abstract::Six men, ages 18 to 34 years, with hypothalamic hypogonadotropism were treated with D-Trp6-luteinizing hormone-releasing hormone (10 micrograms intramuscularly on alternate days) for a period of 6 months. They underwent an intravenous luteinizing hormone-releasing hormone (LH-RH) test (50 micrograms/sq m) before and a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45381-1
更新日期:1981-03-01 00:00:00
abstract::Well-designed and -conducted clinical trials are needed to further advance the field for reproductive medicine. However, current reporting of outcomes of trials is ambiguous and disparate. In this review it is offered that the preferred outcome for clinical trials in reproductive medicine should be live birth. Multipl...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2014.03.026
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between follicular and serum nitric oxide (NO) levels and embryo development and outcome in IVF. DESIGN:Prospective, case-control study. SETTING:University hospital, tertiary medical center. PATIENT(S):Eighteen patients with tubal or peritoneal factor infertility and 18 female p...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.02.097
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To report our experience with genetic screening of oocyte donor candidates and to determine the frequency with which significant genetic issues are identified. DESIGN:Prospective genetic screening of oocyte donor candidates. SETTING:University hospital oocyte donation program. PATIENT(S):Women presenting c...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00109-5
更新日期:1998-07-01 00:00:00