Microdose flare protocol with interrupted follicle stimulating hormone and added androgen for poor responders--an observational pilot study.


OBJECTIVE:To investigate whether temporarily withholding FSH and adding androgen could improve follicular response during a microdose flare protocol in women with slow follicular growth or asynchronous follicular development. DESIGN:Observational pilot study. SETTING:University-affiliated private fertility center. PATIENT(S):Twenty-six women aged 34-47 years with poor response to stimulation or a previous cancelled IVF cycle and with slow or asynchronous follicular growth during a microdose flare cycle. INTERVENTION(S):For 13 women, after initiation of ovarian stimulation using the microdose flare protocol, gonadotropin administration was interrupted and transdermal testosterone gel was added for several days (4.4 ± 1.2 d) starting after cycle day 7 (mean cycle day 10 ± 2.6). MAIN OUTCOME MEASURE(S):FSH, E2, follicular growth, and total number of mature oocytes retrieved were determined for all of the patients. Cycle cancellation rate as well as pregnancy rate following embryo transfer were also documented when applicable. RESULT(S):FSH levels declined (25.2 ± 6.5 to 6.8 ± 3.2 IU/L), E2 levels increased (896 ± 687 to 2,163 ± 1,667 pmol/L), and follicular growth improved significantly during gonadotropin interruption and were tracked for 2 days during this time frame. The average number of oocytes retrieved was 5.3 ± 2.6, and the ratio of mature to total oocytes was 4:5. Four of the 13 women in the interruption group conceived following frozen embryo transfer, whereas none in the control group did. CONCLUSION(S):The androgen-interrupted FSH protocol may improve follicular response to gonadotropins in cycles that might otherwise be cancelled.


Fertil Steril


Fertility and sterility


Mitri F,Behan LA,Murphy CA,Hershko-Klement A,Casper RF,Bentov Y




Has Abstract


2016-01-01 00:00:00














  • Videolaseroscopy for the treatment of endometriosis associated with infertility.

    abstract::Recent advances in laparoscopic surgery have enabled the gynecologic surgeon to treat an increased number of diseases of the reproductive organs by using the laser through the laparoscope. This article reviews the results of 243 patients with infertility associated with endometriosis ranging in severity from mild to e...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nezhat C,Crowgey S,Nezhat F

    更新日期:1989-02-01 00:00:00

  • Microscopic versus macroscopic tubal anastomosis in rabbit fallopian tubes.

    abstract::The importance of the operating microscope in rabbit tubal anastomosis was assessed by operating on 36 rabbits, half with the aid of the operating microscope and half with the aid of low-magnification loupes. The surgeons' operating comfort and sense of assuredness that the anastomoses were being done properly were in...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Goldfarb JM,Utian WH,Weiss R

    更新日期:1983-09-01 00:00:00

  • Introduction: menopausal hormone therapy: where are we today?

    abstract::In this Views and Reviews section, the authors present the most updated information on menopausal hormone therapy (MHT) and an individualized treatment approach. Care of women through the menopausal transition and post-menopausally requires physicians to integrate multi-organ implications of MHT and understand the ful...

    journal_title:Fertility and sterility



    authors: Cedars MI

    更新日期:2014-04-01 00:00:00

  • Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy.

    abstract:OBJECTIVE:To perform a highly detailed semen analysis in a man whose wife had a partial mole. DESIGN:Case report. SETTING:Gynecology departments of two university hospitals and a laboratory of histology/embryology. PATIENT(S):A 32-year-old man whose wife had a partial mole. INTERVENTION(S):Sperm characteristics wer...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chatzimeletiou K,Sioga A,Oikonomou L,Charalampidou S,Kantartzi P,Zournatzi V,Panidis D,Goulis DG,Papadimas I,Tarlatzis BC

    更新日期:2011-06-01 00:00:00

  • A microliter oxygen electrode system for sperm suspensions.

    abstract::A new polarographic oxygen electrode system is described which can accept sperm suspensions with volumes as low as 50 microliters. In this configuration, the electrode tip forms the base of the suspension reaction chamber, and there is no stirring. Consequently, structured fluids such as cervical mucus can be applied....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Katz DF,Blake ET,Mills RN,Fatt I

    更新日期:1978-12-01 00:00:00

  • Psychosocial stress as a cause of infertility.

    abstract::An adaptive model for the evolution of reproductive failure predicted psychosocial stress to increase as anatomic causes of infertility decrease. The nonanatomic infertility group in our study reported greater psychosocial stress than intermediate (P < 0.008) or anatomic groups (P < 0.0005). Controls, women with nonan...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wasser SK,Sewall G,Soules MR

    更新日期:1993-03-01 00:00:00

  • Ovarian steroid hormones differentially regulate thrombospondin-1 expression in cultured endometrial stromal cells: implications for endometriosis.

    abstract::Thrombospondin-1 messenger RNA and protein levels in cultured human endometrial stromal cells (ESCs) treated with 17-beta estradiol (10 nM) were reduced by 47.6% (+/-6.5% SD; P < 0.05) and 49.0% (+/-8.6%; P < 0.05) compared with untreated cells, whereas thrombospondin-1mRNA and protein levels in ESCs treated with prog...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tan XJ,Lang JH,Zheng WM,Leng JH,Zhu L

    更新日期:2010-01-01 00:00:00

  • Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor alpha and interleukin-8 expression.

    abstract:OBJECTIVE:To evaluate the effect of lipopolysaccharide (LPS) on the expression of tumor necrosis factor alpha (TNFalpha) and interleukin-8 (IL-8) protein in endometriotic stromal cells (ESC) and their effect on the proliferation of ESC. DESIGN:Prospective study. SETTING:Department of Obstetrics and Gynecology, Tottor...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Iba Y,Harada T,Horie S,Deura I,Iwabe T,Terakawa N

    更新日期:2004-10-01 00:00:00

  • Laparoscopic repair of bilateral inguinal hernias in a patient with müllerian agenesis.

    abstract:OBJECTIVE:To report a case of laparoscopic repair of bilateral inguinal hernias in a patient with müllerian agenesis. DESIGN:Case report. SETTING:Hospital. PATIENT(S):An 18-year-old woman with müllerian agenesis who presented with symptomatic inguinal hernias containing ovaries. INTERVENTION(S):Laparoscopic repair ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vaughn TC,Jones HL

    更新日期:2000-06-01 00:00:00

  • Antiestrogenic action of high-dose clomiphene in primates pituitary augmentation but with ovarian attenuation.

    abstract::Since the dominant follicle is selected by days 5 to 7 of the menstrual cycle, we assessed the differential effects of high-dose clomiphene (25 mg daily) by giving 5-day courses either before (days 1 to 5), during (days 5 to 9), or after (days 9 to 13) emergence of the selected dominant follicle in monkeys. Peripheral...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Marut EL,Hodgen GD

    更新日期:1982-07-01 00:00:00

  • Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome.

    abstract:OBJECTIVE:To study the association between two single-nucleotide polymorphisms (SNPs) variants (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) and polycystic ovary syndrome (PCOS) in PCOS family trios. DESIGN:Family-based study. SETTING:University hospital. PATIENT(S):A total of 224 unrelated PCOS proband...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zhang W,Wei D,Sun X,Li J,Yu X,Shi Y,Chen ZJ

    更新日期:2014-05-01 00:00:00

  • High levels of mineralocorticoids in preovulatory follicular fluid could contribute to oocyte development.

    abstract:OBJECTIVE:To identify aldosterone and precursors in ovarian follicles and to relate levels of mineralocorticoids to previously described renin-angiotensin system follicular fluid content. DESIGN:Experimental. SETTING:Academic laboratory and affiliated large private practice. PATIENT(S):Women undergoing oocyte retrie...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sneeringer R,Penzias AS,Barrett B,Usheva A

    更新日期:2011-01-01 00:00:00

  • Preimplantation genetic diagnosis for Marfan syndrome.

    abstract:OBJECTIVE:To develop and apply efficient and reliable protocols for preimplantation genetic diagnosis (PGD) for Marfan syndrome. DESIGN:Two mutation-specific protocols were developed, and the markers D15S1028, D15S992, D15S196, D15S576, D15S123, and D15S143 were used to set up four multiplex polymerase chain reactions...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Spits C,De Rycke M,Verpoest W,Lissens W,Van Steirteghem A,Liebaers I,Sermon K

    更新日期:2006-08-01 00:00:00

  • Effects of pentoxifylline on human sperm motility in normospermic individuals using computer-assisted analysis.

    abstract:OBJECTIVE:To determine if pentoxifylline has an in vitro effect on human sperm motility in subjects with normal semen analysis. DESIGN:Prospective, longitudinal study of the effect of pentoxifylline on normospermic semen samples using computerized analysis. SETTING:The Assisted Conception Unit, Royal Maternity Hospit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lewis SE,Moohan JM,Thompson W

    更新日期:1993-02-01 00:00:00

  • Pregnancies following ultrasound-guided drainage of tubo-ovarian abscess.

    abstract:OBJECTIVE:To study fertility among women treated by means of ultrasound-guided drainage and antibiotics for tubo-ovarian abscess (TOA). DESIGN:Retrospective cohort study. SETTING:A tertiary referral center. PATIENT(S):One hundred women of reproductive age treated for TOA between June 1986 and July 2003. INTERVENTIO...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gjelland K,Granberg S,Kiserud T,Wentzel-Larsen T,Ekerhovd E

    更新日期:2012-07-01 00:00:00

  • Optimal timing of oocyte maturation and its relationship with the spindle assembly and developmental competence of in vitro matured human oocytes.

    abstract:OBJECTIVE:To develop and test a simple, feasible approach to improve spindle assembly and developmental competence of human in vitro matured oocytes by parthenogenetic activation in maturation medium. DESIGN:Prospective, randomized study. SETTING:University research laboratory-based assisted reproductive technology l...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Yu Y,Yan J,Liu ZC,Yan LY,Li M,Zhou Q,Qiao J

    更新日期:2011-07-01 00:00:00

  • Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization.

    abstract:OBJECTIVE:To compare the amount of regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) in follicular fluid (FF) of patients with and without endometriosis and to determine their oocyte fertilization and pregnancy rates. DESIGN:Case-control study. SETTING...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Xu H,Schultze-Mosgau A,Agic A,Diedrich K,Taylor RN,Hornung D

    更新日期:2006-12-01 00:00:00

  • Ultrasonographic-guided percutaneous transabdominal puncture for oocyte retrieval in a rare patient with Rokitansky syndrome in an in vitro fertilization surrogacy program.

    abstract:OBJECTIVE:To describe the option of ultrasonographic-guided percutaneous transabdominal puncture for ovum pickup in a rare case of Rokitansky syndrome with subcostal located ovaries and a right single kidney. DESIGN:Technique and instrumentation. SETTING:A university-based hospital IVF and Reproductive Medicine Unit....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Raziel A,Vaknin Z,Schachter M,Strassburger D,Herman A,Ron-El R,Friedler S

    更新日期:2006-12-01 00:00:00

  • Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies.

    abstract:OBJECTIVE:To study the controversial association between human leukocyte antigen-G (HLA-G) 14 bp polymorphism and recurrent pregnancy loss (RPL). We performed a meta-analysis of studies in the literature that enrolled only women of European countries who experienced RPL spontaneously or after undergoing IVF. DESIGN:Sy...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析


    authors: Monti M,Lupoli R,Sosa Fernandez LM,Cirillo F,Di Minno MND

    更新日期:2019-09-01 00:00:00

  • Abdominal pregnancy complicated by genital and renal tuberculosts and hemolytic anemia.

    abstract::After a 10-year period of primary infertility, a patient presented with abdominal pregnancy. Known to have had previously treated genital tuberculosis, on admission she was found to have renal tuberculosis and autoimmune hemolytic anemia. After fetal death, laparotomy was performed and the fetus was removed. The patie...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Semchyshyn S,Cecutti A

    更新日期:1975-11-01 00:00:00

  • Relationship and parenthood in IVF couples with twin and singleton pregnancies compared with spontaneous singleton primiparous couples--a prospective 5-year follow-up study.

    abstract:OBJECTIVE:To analyze relationship and parenthood in IVF twin couples, IVF singleton couples, and spontaneously pregnant primiparous couples. SETTING:Southeast region of Sweden. DESIGN:Prospective case-control study. PATIENT(S):In total, 24 women and men who became pregnant with twins, consecutively, and expected the...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sydsjö G,Wadsby M,Sydsjö A,Selling KE

    更新日期:2008-03-01 00:00:00

  • Deep endometriosis and bladder and detrusor functions in women without urinary symptoms: a pilot study through an unexplored world.

    abstract:OBJECTIVE:To evaluate the impact of deep endometriosis (DE) on bladder function, focusing on detrusor pattern, in patients without preoperative urinary symptoms. DESIGN:Prospective study. SETTING:Academic research center. PATIENT(S):A total of 25 asymptomatic patients: 12 patients with DE (group 1) and 13 patients w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Serati M,Cattoni E,Braga A,Uccella S,Cromi A,Ghezzi F

    更新日期:2013-11-01 00:00:00

  • The cation composition of the seminal plasma and prostatic fluid and its correlation to semen quality.

    abstract::The concentrations of calcium, magnesium, and zinc were measured by atomic absorption spectrometry. The concentrations of all three cations were found to be strongly correlated with one another and with acidity (pH). Analysis of the relative concentrations in prostatic fluid, split ejaculates, and whole seminal plasma...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Homonnai ZT,Matzkin H,Fainman N,Paz G,Kraicer PF

    更新日期:1978-05-01 00:00:00

  • Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum.

    abstract::We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, o...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Heilier JF,Donnez O,Van Kerckhove V,Lison D,Donnez J

    更新日期:2006-05-01 00:00:00

  • Day 2 embryo transfer (ET) and day 3 ET afford similar reproductive outcomes in the poor responder.

    abstract::A retrospective review of 237 initial, fresh nondonor IVF cycles in which all embryos generated during the cycle were transferred on either day 2 (n = 109) or day 3 (n = 128) were evaluated with regards to reproductive outcomes. Patients who underwent a day 2 ET had similar conception (18% vs. 16%; relative risk [RR],...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dayal MB,Frankfurter D,Athanasiadis I,Peak D,Dubey A,Gindoff PR

    更新日期:2011-03-01 00:00:00

  • Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women.

    abstract::The specific radioimmunoassay system was developed for the titration of the antibodies to porcine zona pellucida (ZP) in human sera by using 125I-labeled purified porcine ZP as antigen, which is known to have cross-reactivity with human ZP. The antibodies in human sera were detected in 3 of 11 (27%) women with unexpla...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kurachi H,Wakimoto H,Sakumoto T,Aono T,Kurachi K

    更新日期:1984-02-01 00:00:00

  • Transmyometrial embryo transfer after difficult immediate mock transcervical transfer.

    abstract:OBJECTIVE:To evaluate the place of ultrasound-directed transvaginal transmyometrial ET in a protocol using both the transcervical and transmyometrial routes in a step-wise fashion. DESIGN:A prospective descriptive clinical study. SETTING:A university-based assisted conception unit. PATIENTS:Thirteen patients who had...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sharif K,Afnan M,Lenton W,Bilalis D,Hunjan M,Khalaf Y

    更新日期:1996-05-01 00:00:00

  • Changing ovarian stimulation parameters in a subsequent cycle does not increase the number of euploid embryos.

    abstract:OBJECTIVE:To compare the euploidy outcome in patients that underwent 2 ovarian stimulation cycles with trophectoderm biopsy. DESIGN:Retrospective repeated-measures cohort study. SETTING:University-based fertility center. PATIENT(S):A total of 116 patients, from 2011 through 2013, that underwent 2 ovarian stimulation...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hodes-Wertz B,McCulloh DH,Berkeley AS,Grifo JA

    更新日期:2015-04-01 00:00:00

  • Müllerian-inhibiting substance in follicular fluid and serum: a comparison of patients with tubal factor infertility, polycystic ovary syndrome, and endometriosis.

    abstract:OBJECTIVE:To determine Müllerian inhibiting substance (MIS) levels in follicular fluid (FF) and sera of IVF patients. DESIGN:Prospective study. SETTING:Fertility center. PATIENT(S):Sixty-six patients: 20 with tubal factor infertility, 17 with polycystic ovary syndrome (PCOS), and 29 with endometriosis. INTERVENTION...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fallat ME,Siow Y,Marra M,Cook C,Carrillo A

    更新日期:1997-05-01 00:00:00

  • Comparison of pronuclear zygote morphology and early cleavage status of zygotes as additional criteria in the selection of day 3 embryos: a randomized study.

    abstract:OBJECTIVE:Both pronuclear morphology and early zygote cleavage have been used in combination with day 3 criteria to predict implantation and pregnancy. However, in routine practice, it is impractical to use both these criteria to select embryos on day 3. The objective of the present study was to find which of the two c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Chen C,Kattera S

    更新日期:2006-02-01 00:00:00