Microdose flare protocol with interrupted follicle stimulating hormone and added androgen for poor responders--an observational pilot study.


OBJECTIVE:To investigate whether temporarily withholding FSH and adding androgen could improve follicular response during a microdose flare protocol in women with slow follicular growth or asynchronous follicular development. DESIGN:Observational pilot study. SETTING:University-affiliated private fertility center. PATIENT(S):Twenty-six women aged 34-47 years with poor response to stimulation or a previous cancelled IVF cycle and with slow or asynchronous follicular growth during a microdose flare cycle. INTERVENTION(S):For 13 women, after initiation of ovarian stimulation using the microdose flare protocol, gonadotropin administration was interrupted and transdermal testosterone gel was added for several days (4.4 ± 1.2 d) starting after cycle day 7 (mean cycle day 10 ± 2.6). MAIN OUTCOME MEASURE(S):FSH, E2, follicular growth, and total number of mature oocytes retrieved were determined for all of the patients. Cycle cancellation rate as well as pregnancy rate following embryo transfer were also documented when applicable. RESULT(S):FSH levels declined (25.2 ± 6.5 to 6.8 ± 3.2 IU/L), E2 levels increased (896 ± 687 to 2,163 ± 1,667 pmol/L), and follicular growth improved significantly during gonadotropin interruption and were tracked for 2 days during this time frame. The average number of oocytes retrieved was 5.3 ± 2.6, and the ratio of mature to total oocytes was 4:5. Four of the 13 women in the interruption group conceived following frozen embryo transfer, whereas none in the control group did. CONCLUSION(S):The androgen-interrupted FSH protocol may improve follicular response to gonadotropins in cycles that might otherwise be cancelled.


Fertil Steril


Fertility and sterility


Mitri F,Behan LA,Murphy CA,Hershko-Klement A,Casper RF,Bentov Y




Has Abstract


2016-01-01 00:00:00














  • Intrauterine injection of human chorionic gonadotropin before embryo transfer can improve in vitro fertilization-embryo transfer outcomes: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To evaluate whether intrauterine injection of hCG before embryo transfer can improve IVF-ET outcomes. DESIGN:Meta-analysis. SETTING:Not applicable. PATIENT(S):Infertile women who underwent IVF-ET and received an intrauterine injection of hCG before ET. INTERVENTION(S):Infertile women treated with or witho...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Gao M,Jiang X,Li B,Li L,Duan M,Zhang X,Tian J,Qi K

    更新日期:2019-07-01 00:00:00

  • Reactive oxygen species in human semen: validation and qualification of a chemiluminescence assay.

    abstract:OBJECTIVE:To standardize and validate an assay for reactive oxygen species (ROS) in human semen. DESIGN:ROS levels assayed in blanks, negative and positive control samples (30% H2O2), and human semen, with the use of a luminol-based chemiluminescence assay measured in a single tube luminometer. SETTING:Andrology labo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vessey W,Perez-Miranda A,Macfarquhar R,Agarwal A,Homa S

    更新日期:2014-12-01 00:00:00

  • Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antag

    abstract:OBJECTIVE:To investigate relations between dose of GnRH antagonist and follicular phase characteristics. DESIGN:Randomized controlled multicenter trial. SETTING:Tertiary referral fertility centers. PATIENT(S):Three hundred and twenty-nine IVF patients. INTERVENTION(S):Ovarian stimulation for IVF with recombinant FS...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: de Jong D,Macklon NS,Eijkemans MJ,Mannaerts BM,Coelingh Bennink HJ,Fauser BC,Ganirelix Dose-Finding Study Group.

    更新日期:2001-04-01 00:00:00

  • Supplemented tissue culture medium 199 is a better medium for in vitro maturation of oocytes from women with polycystic ovary syndrome women than human tubal fluid.

    abstract:OBJECTIVE:To compare oocyte maturation, fertilization and cleavage rates, and embryonic developmental quality after culture of human immature oocytes from polycystic ovary syndrome (PCOS) patients in human tubal fluid (HTF) or tissue culture medium (TCM) 199. DESIGN:Prospective, randomized, controlled trial. SETTING:...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: de Araujo CH,Nogueira D,de Araujo MC,Martins Wde P,Ferriani RA,dos Reis RM

    更新日期:2009-02-01 00:00:00

  • Next-generation sequencing reveals differentially expressed small noncoding RNAs in uterine leiomyoma.

    abstract:OBJECTIVE:To determine the expression profile of small noncoding RNAs (sncRNAs) in leiomyoma, which has not been investigated to date. DESIGN:Laboratory-based investigation. SETTING:Academic center. PATIENT(S):Women undergoing hysterectomy for benign indications. INTERVENTION(S):Next-generation sequencing and scree...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chuang TD,Xie Y,Yan W,Khorram O

    更新日期:2018-05-01 00:00:00

  • Modification of germinal epithelium ischemia by perfusion.

    abstract::Three groups of dogs underwent testicular ischemia for a 3-hour period. Group I (10 animals) was not subsequently perfused. Group II (10 animals) underwent subsequent perfusion by a new in vivo reversible method via the internal spermatic artery with heparinized saline. Group III (5 animals) underwent perfusion with S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Stiles RE Jr,Klugo RC,Farah RN,Cerny JC

    更新日期:1977-11-01 00:00:00

  • Similar ongoing pregnancy rates after blastocyst transfer in fresh donor cycles and autologous cycles using cryopreserved bipronuclear oocytes suggest similar viability of transferred blastocysts.

    abstract::This retrospective cohort study compared blastocyst transfers in 136 fresh oocyte donor cycles and 69 autologous cycles using blastocysts derived from culture of thawed bipronuclear oocytes, all with oocytes derived from patients or donors less than 35 years old. The autologous cycles and oocyte donor cycles had simil...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Shapiro BS,Daneshmand ST,Garner FC,Aguirre M,Hudson C,Thomas S

    更新日期:2010-01-01 00:00:00

  • Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles.

    abstract:OBJECTIVE:To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate following fresh donor oocyte IVF-ET. DESIGN:Retrospective cohort study. SETTING:Academic reproductive medicine practice. PATIENT(S):Two hundred thirty-seven consecutive fresh donor oo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hariton E,Kim K,Mumford SL,Palmor M,Bortoletto P,Cardozo ER,Karmon AE,Sabatini ME,Styer AK

    更新日期:2017-08-01 00:00:00

  • Outcome of assisted reproductive technology in women over the age of 41.

    abstract:OBJECTIVE:To analyze the results of ongoing pregnancies and deliveries after assisted reproductive technology (ART) in women aged >/=41 years, stratified by year of age. DESIGN:Retrospective study. SETTING:University hospital, IVF unit. PATIENT(S):A total of 431 IVF and intracytoplasmic sperm injection (ICSI) cycles...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ron-El R,Raziel A,Strassburger D,Schachter M,Kasterstein E,Friedler S

    更新日期:2000-09-01 00:00:00

  • Zygote intrafallopian transfer or in vitro fertilization and embryo transfer for the treatment of male-factor infertility: a prospective randomized trial.

    abstract:OBJECTIVE:To compare zygote intrafallopian transfer (ZIFT) and in vitro fertilization and embryo transfer (IVF-ET) as treatments of male-factor infertility. DESIGN:Patients were prospectively randomized to ZIFT or IVF-ET. SETTING:In vitro fertilization program of the Centre for Reproductive Medicine of the Dutch-spea...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tournaye H,Devroey P,Camus M,Valkenburg M,Bollen N,Van Steirteghem AC

    更新日期:1992-08-01 00:00:00

  • The effect of 6 weeks of testosterone treatment on pulsatile luteinizing hormone secretion in eugonadal female-to-male transsexuals.

    abstract::Polycystic ovary disease generally is associated with elevated androgen levels and elevated luteinizing hormone (LH) levels, whereas follicle-stimulating hormone (FSH) levels are (sub)normal. To assess the role of androgens on gonadotropin secretion, we investigated the effect of 6 weeks of testosterone (T) undecanoat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Scheele F,Hompes PG,Gooren LJ,Spijkstra JJ,Spinder T

    更新日期:1991-03-01 00:00:00

  • Evidence-based approach to unexplained infertility: a systematic review.

    abstract:OBJECTIVE:To summarize the available evidence for the efficacy of various treatments for unexplained infertility. DESIGN:Systematic review. SETTING:Not applicable. PATIENT(S):Patients aged 18-40 years with unexplained infertility. INTERVENTION(S):Clomiphene citrate, letrozole, timed intercourse, IUI, gonadotropins,...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Gunn DD,Bates GW

    更新日期:2016-06-01 00:00:00

  • Association of adolescent obesity and lifetime nulliparity--the Study of Women's Health Across the Nation (SWAN).

    abstract:OBJECTIVE:To evaluate whether adolescent obesity is associated with difficulties in becoming pregnant later in life. DESIGN:Cross-sectional analysis of baseline data from a longitudinal cohort. SETTING:Multiethnic, community-based observational study of U.S. women. PATIENT(S):Three thousand one hundred fifty-four mi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Polotsky AJ,Hailpern SM,Skurnick JH,Lo JC,Sternfeld B,Santoro N

    更新日期:2010-04-01 00:00:00

  • One versus two inseminations per cycle in intrauterine insemination with sperm from patients' husbands: a systematic review of the literature.

    abstract:OBJECTIVE:To study the efficacy of performing two inseminations per cycle in IUI with husband's sperm compared with one insemination per cycle. DESIGN:Meta-analysis. SETTING:Randomized and prospective trials comparing two inseminations vs. one insemination per cycle in IUI with husband's sperm, retrieved by MEDLINE a...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章,meta分析,评审


    authors: Osuna C,Matorras R,Pijoan JI,Rodríguez-Escudero FJ

    更新日期:2004-07-01 00:00:00

  • A study of prolactin, follicle-stimulating hormone, and luteinizing hormone in puerperium: spontaneous variations and the effect of metergoline.

    abstract::In 80 normal puerperae, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), including human chorionic gonadotropin (hCG/LH), and prolactin (PRL) levels were evaluated 6 to 29 hours after vaginal delivery. In these puerperae, PRL levels were higher and FSH levels were lower than in menstruating women; h...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Falsetti L,Voltolini AM,Pollini C,Pontiroli AE

    更新日期:1982-03-01 00:00:00

  • Prenatal hyperandrogenism and lipid profile during different age stages: an experimental study.

    abstract:OBJECTIVE:The present study investigates the effect of prenatal hyperandrogenization on lipid metabolism and oxidant/antioxidant balance. DESIGN:Experimental study. SETTING:Research institute. ANIMAL(S):Pregnant Sprague Dawley rats were subcutaneously injected with 2 mg free T between days 16 and 19 of pregnancy, an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Heber MF,Ferreira SR,Vélez LM,Motta AB

    更新日期:2013-02-01 00:00:00

  • Screening for subclinical inflammation in ejaculates.

    abstract:OBJECTIVE:To determine the clinical significance of albumin determination in ejaculates by means of an easy office test to screen semen samples for subclinical infection-inflammation. PATIENTS:One hundred fifty-nine randomly chosen males of couples with longstanding infertility (median duration of infertility 4 years ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Eggert-Kruse W,Probst S,Rohr G,Aufenanger J,Runnebaum B

    更新日期:1995-11-01 00:00:00

  • Low-dose human chorionic gonadotropin alone can complete follicle maturity: successful application to modified natural cycle in vitro fertilization.

    abstract:OBJECTIVE:To investigate the feasibility of utilizing low-dose hCG alone to complete follicle maturity in a natural cycle, without the need for antecedent exogenous FSH stimulation. DESIGN:Case series. SETTING:Academic fertility program. PATIENT(S):Normally ovulatory women with infertility thought to be predominantl...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Paulson RJ,Chung K,Quaas AM,Mucowski SJ,Jabara SI,Bendikson KA

    更新日期:2016-05-01 00:00:00

  • Two cases of cholestasis in the first trimester of pregnancy after ovarian hyperstimulation.

    abstract:OBJECTIVE:To report two cases of early onset cholestasis of pregnancy associated with IVF and ovarian hyperstimulation syndrome. DESIGN:Case report. SETTING:University-based IVF program. PATIENT(S):Two patients with first-trimester cholestasis of pregnancy after IVF that was associated with ovarian hyperstimulation ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zamah AM,El-Sayed YY,Milki AA

    更新日期:2008-10-01 00:00:00

  • Environmental contaminants and pregnancy outcomes.

    abstract:OBJECTIVE:To review selected environmental, occupational, and other important risk factors for the following adverse pregnancy outcomes: low birth weight (LBW), intrauterine growth retardation (IUGR), and preterm delivery (PTD). DESIGN:The evidence is explored in greater detail for environmental tobacco smoke, drinkin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Windham G,Fenster L

    更新日期:2008-02-01 00:00:00

  • Inter- and intrafamilial variability in premature pubarche and polycystic ovary syndrome.

    abstract:OBJECTIVE:To ascertain the extent of phenotypic heterogeneity for premature pubarche and polycystic ovary syndrome between and within families. DESIGN:Association study. SETTING:Academic research environment. PATIENT(S):Three families in which the propositus had presented with either premature pubic hair or adolesce...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sanders EB,Aston CE,Ferrell RE,Witchel SF

    更新日期:2002-09-01 00:00:00

  • Patterns of estradiol response in patients with endogenous gonadotropin surges during follicular recruitment in an in vitro fertilization and embryo transfer program.

    abstract::This report is an analysis of 16 cycles in 15 patients stimulated with human menopausal gonadotropin and clomiphene citrate for the purpose of follicular recruitment in an in vitro fertilization program, all of which resulted in endogenous luteinizing hormone (LH) surges. A study of the pattern of estradiol (E2) respo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nader S,Berkowitz AS,Ochs D,Wolf DP,Maklad N,Held B

    更新日期:1986-09-01 00:00:00

  • Interruption of pregnancy by prostaglandin 15-methyl F2alpha.

    abstract::The current study was formulated to investigate the abortifacient activity of prostaglandin 15-methyl F2alpha (15-methyl PGF2alpha) administered intramuscularly to 80 healthy women with gestations between 8 and 22 weeks. Goals were the establishment of an effective dosage schedule and assessment of the incidence and s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bolognese RJ,Corson SL

    更新日期:1975-07-01 00:00:00

  • WITHDRAWN: What makes them split? Identifying risk factors that lead to monozygotic twins after in vitro fertilization.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Knopman JM,Krey LC,Oh C,Lee J,McCaffrey C,Noyes N

    更新日期:2013-10-07 00:00:00

  • A common Asn680Ser polymorphism in the follicle-stimulating hormone receptor gene is not associated with ovarian response to gonadotropin stimulation in patients undergoing in vitro fertilization.

    abstract:OBJECTIVE:To assess the role of the variant p.Asn680Ser in the follicle-stimulating hormone receptor (FSHR) gene in determining ovarian response in patients undergoing in vitro fertilization (IVF) treatment. DESIGN:Prospective observational study. SETTING:Tertiary referral center for reproductive medicine. PATIENT(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mohiyiddeen L,Newman WG,Cerra C,McBurney H,Mulugeta B,Roberts SA,Nardo LG

    更新日期:2013-01-01 00:00:00

  • Professionalism and member attitudes.

    abstract::A recent survey of American Society for Reproductive Medicine (ASRM) members indicates that they express a commitment to professional standards and a desire for advocacy. Their attitudes echo traditional values of professionalism, upon which ASRM should capitalize. ...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章


    authors: Brzyski RG

    更新日期:2004-09-01 00:00:00

  • Follicle growth curves and hormonal patterns in patients with the luteinized unruptured follicle syndrome.

    abstract::A prospective longitudinal and standardized study is presented, dealing with ultrasonographic and hormonal characteristics of the luteinized unruptured follicle (LUF) syndrome. Among 600 cycles monitored in 270 infertility patients, 40 cycles in 27 patients showed no evidence of follicle rupture, in spite of signs of ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hamilton CJ,Wetzels LC,Evers JL,Hoogland HJ,Muijtjens A,de Haan J

    更新日期:1985-04-01 00:00:00

  • Correlation between serum antichlamydial antibodies and tubal factor as a cause of infertility.

    abstract::Although salpingitis frequently produces tubal damage and infertility, many women with tubal factor as a cause of their infertility do not have a clinical history of salpingitis. In order to investigate whether or not some such cases might be due to subclinical chlamydial infections, we measured antichlamydial antibod...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jones RB,Ardery BR,Hui SL,Cleary RE

    更新日期:1982-11-01 00:00:00

  • Combined use of clomiphene and intranasal luteinizing hormone-releasing hormone for induction of ovulation in chronically anovulatory women.

    abstract::Combined therapy with clomiphene and intranasal luteinizing hormone-releasing hormone (LHRH) was used to induce ovulation in eight chronically anovulatory patients under treatment for infertility. Clomiphene, 100 mg daily, was given from the 5th to the 9th day of the cycle. Synthetic LHRH was administered intranasally...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Phansey SA,Barnes MA,Williamson HO,Sagel J,Nair RM

    更新日期:1980-11-01 00:00:00

  • High pregnancy rates can be achieved after freezing and thawing human blastocysts.

    abstract:OBJECTIVE:To examine the results of a 3-year trial using blastocyst cryopreservation to limit multiple pregnancy and optimize overall pregnancy per cycle. DESIGN:Retrospective clinical evaluation of pregnancy rates after freezing and thawing human blastocysts. SETTING:Tertiary-care academic center. PATIENT(S):Seven ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Veeck LL,Bodine R,Clarke RN,Berrios R,Libraro J,Moschini RM,Zaninovic N,Rosenwaks Z

    更新日期:2004-11-01 00:00:00