当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Gonadotropin suppression for the treatment of karyotypically normal spontaneous premature ovarian failure: a controlled trial.

Gonadotropin suppression for the treatment of karyotypically normal spontaneous premature ovarian failure: a controlled trial.

Abstract：

OBJECTIVE:To determine if gonadotropin suppression improves ovarian follicle function or ovulation rates in patients with karyotypically normal spontaneous premature ovarian failure. DESIGN:Prospective, double-blind, placebo-controlled, crossover trial. SETTING:Tertiary care research institution. INTERVENTIONS:Two intervention phases lasting 4 months each: one placebo phase, and one treatment phase during which each patient received daily subcutaneous injections of 300 micrograms of the gonadotropin-releasing hormone agonist (GnRH-a) deslorelin. During both phases, patients took a standardized estrogen (E) replacement regimen. PATIENTS, PARTICIPANTS:Twenty-six patients with karyotypically normal spontaneous premature ovarian failure ranging in age from 18 to 39 years. MAIN OUTCOME MEASURES:We measured serum estradiol (E2) and progesterone (P) levels weekly during the 2 months after each intervention. We defined a serum E2 greater than 50 pg/mL (184 pmol/L) as evidence for ovarian follicle function and a serum P greater than 3.0 ng/mL (9.5 nmol/L) as evidence for ovulation. RESULTS:The GnRH-a therapy did not significantly enhance recovery of ovarian follicle function or the chance of ovulation. The power to detect a 40% and a 33% ovulation success rate with therapy was 0.95 and 0.83, respectively. We found evidence for ovarian follicle function in 11 of 23 women (48%), and 4 women (17%) ovulated. CONCLUSIONS:Patients with karyotypically normal spontaneous premature ovarian failure treated with E replacement did not benefit from the additional gonadotropin suppression achieved with GnRH-a. Because these patients have a significant possibility of spontaneous remission, attempts to induce ovulation should be limited to controlled trials designed to determine safety and effectiveness.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Nelson LM,Kimzey LM,White BJ,Merriam GR

doi

10.1016/s0015-0282(16)54775-x

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

50-5

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54775-X

journal_volume

57

pub_type

临床试验,杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Point of failure as a predictor of in vitro fertilization treatment discontinuation.

    abstract：:Among 2,245 women, those who experienced a chemical pregnancy that failed to progress to a clinically recognized pregnancy or a spontaneous abortion on their first IVF cycle were more likely to discontinue IVF treatment than those whose first cycle ended before embryo transfer or who did not have a positive pregnancy ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.07.1732

    authors： Pearson KR,Hauser R,Cramer DW,Missmer SA

    更新日期：2009-04-01 00:00:00

  • Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis.

    abstract：OBJECTIVE:To evaluate novel clinical markers of endometriosis including the neurotrophins brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 4/5 (NT4/5) and compare them to others previously reported in the literature including cancer antigen 125 (CA-125) and C-reactive protein (CRP)....

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.09.003

    authors： Wessels JM,Kay VR,Leyland NA,Agarwal SK,Foster WG

    更新日期：2016-01-01 00:00:00

  • Clinical evaluation of the effects of combined treatment with bromocriptine and spironolactone in two women with the polycystic ovary syndrome.

    abstract：:Two women with the polycystic ovary syndrome were treated with bromocriptine (15 to 20 mg/day) in combination with spironolactone (100 mg/day). In the first woman the combined therapy induced a marked reduction of hirsutism, with ensuing ovulation and pregnancy. In the second woman, who had hyperthecosis and had been ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)45554-8

    authors： Blum I,Bruhis S,Kaufman H

    更新日期：1981-06-01 00:00:00

  • Profound teratospermia does not influence sex chromosomal aneuploidy rate in in vitro fertilization-preimplantation genetic diagnosis cycles.

    abstract：:Because spermatocyte meiotic error results in embryonic sex chromosomal aneuploidy, it is speculated that teratospermia correlates with increased embryonic sex chromosomal abnormalities. Our findings contradict this theory, suggesting that morphology does not correlate with sex chromosomal genotype. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.07.1006

    authors： Dayal MB,Gindoff PR,Zarek S,Peak D,Dubey A,Frankfurter D

    更新日期：2010-02-01 00:00:00

  • Sperm penetration into cervical mucus in vitro. I. Comparative studies.

    abstract：:Comparative studies have been carried out on the behavior of human and bovine spermatozoa toward homologous cervical mucus in vitro. In both cases the degree of sperm penetration and the pattern of sperm motility were influenced in a characteristic fashion by prior manipulation of the mucus: the most rapid and extensi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Gaddum-Rosse P,Blandau RJ,Lee WI

    更新日期：1980-06-01 00:00:00

  • Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer.

    abstract：OBJECTIVE:To evaluate the efficacy of reoperation for stage III or IV endometriosis-related infertility versus IVF-ET. DESIGN:Retrospective analysis. SETTING:In vitro fertilization-embryo transfer unit and tertiary infertility clinic. PATIENTS:Twenty-three couples with stage III or IV endometriosis-related infertili...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(16)58215-6

    authors： Pagidas K,Falcone T,Hemmings R,Miron P

    更新日期：1996-04-01 00:00:00

  • One versus two inseminations per cycle in intrauterine insemination with sperm from patients' husbands: a systematic review of the literature.

    abstract：OBJECTIVE:To study the efficacy of performing two inseminations per cycle in IUI with husband's sperm compared with one insemination per cycle. DESIGN:Meta-analysis. SETTING:Randomized and prospective trials comparing two inseminations vs. one insemination per cycle in IUI with husband's sperm, retrieved by MEDLINE a...

    journal_title：Fertility and sterility

    pub_type： 评论,杂志文章,meta分析,评审

    doi：10.1016/j.fertnstert.2003.12.035

    authors： Osuna C,Matorras R,Pijoan JI,Rodríguez-Escudero FJ

    更新日期：2004-07-01 00:00:00

  • The heparin-glutathione test: an alternative to the hypo-osmotic swelling test to select viable sperm for intracytoplasmic sperm injection.

    abstract：OBJECTIVE:To evaluate the heparin-glutathione test (HEGLUT) for the selection of viable sperm for intracytoplasmic sperm injection (ICSI). DESIGN:A prospective study. SETTING:Department of Pediatrics, Obstetrics and Gynecology, University of Valencia and Instituto Valenciano de Infertilidad. PATIENT(S):Semen samples...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(98)00334-3

    authors： Vendrell FJ,Rubio C,Tarín JJ

    更新日期：1998-12-01 00:00:00

  • Spontaneous and prostaglandin- or oxytocin-induced motility of rat ovaries isolated during different stages of the estrous cycle: effects of norepinephrine.

    abstract：:Ovaries isolated from rats in different stages of the sex cycle were explored for spontaneous or drug-induced contractile activity. The number of spontaneously active ovaries as well as the magnitude of the isometrically developed tension and frequency of contractions were greater during the periovulatory interval (la...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)41724-3

    authors： Sterin-Borda L,Borda E,Gimeno MF,Gimeno AL

    更新日期：1976-03-01 00:00:00

  • Laparoscopic bipolar coagulation of uterine vessels: a new method for treating symptomatic fibroids.

    abstract：OBJECTIVE:To evaluate the effects of laparoscopic bipolar coagulation of uterine vessels in treating symptomatic fibroids. DESIGN:Prospective clinical study. SETTING:University-affiliated tertiary referral center. PATIENT(S):Eighty-seven women with symptomatic fibroids warranting surgical treatment and wanting to re...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(00)01724-6

    authors： Liu WM,Ng HT,Wu YC,Yen YK,Yuan CC

    更新日期：2001-02-01 00:00:00

  • The Lupron screening test: tailoring the use of leuprolide acetate in ovarian stimulation for in vitro fertilization.

    abstract：STUDY OBJECTIVE:To evaluate the prognostic and therapeutic value of a Lupron (leuprolide acetate; Tap Pharmaceuticals, North Chicago, IL) screening test before ovarian stimulation for in vitro fertilization (IVF). DESIGN:Prospective. SETTING:Outpatient IVF program. PATIENTS:Eighty patients exhibited four early estra...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)54421-5

    authors： Padilla SL,Smith RD,Garcia JE

    更新日期：1991-07-01 00:00:00

  • Assisted fertility using electroejaculation in men with spinal cord injury--a review of literature.

    abstract：OBJECTIVE:To review the effectiveness of rectal probe electroejaculation in terms of pregnancy in treatment of anejaculatory males due to spinal cord injury. The characteristics of electroejaculates also are examined. DATA IDENTIFICATION:All English language studies reporting pregnancies as a result of electroejaculat...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：

    authors： Chung PH,Yeko TR,Mayer JC,Sanford EJ,Maroulis GB

    更新日期：1995-07-01 00:00:00

  • Treatment of cervical mucus with lectins: effect on sperm migration.

    abstract：:Treatment of midcycle human cervical mucus with the lectins Ulex europaeus agglutinin I (UE), wheat germ agglutinin (WGA), and peanut agglutinin (PA) did not alter the ability of spermatozoa to enter and migrate through the mucus. These lectins form glycoconjugates by binding to L-fucose (UE), N-acetylglucosamine and ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)48979-x

    authors： Snyder MG,Zaneveld LJ

    更新日期：1985-11-01 00:00:00

  • Comparative outcomes of hysteroscopic examinations performed after uterine artery embolization or laparoscopic uterine artery occlusion to treat leiomyomas.

    abstract：:Hysteroscopic examination of the uterine cavity revealed that patients previously treated for intramural myoma(s) by uterine artery embolization had a significantly higher incidence of abnormal findings compared with patients treated by laparoscopic occlusion of uterine arteries (59.5% vs. 2.7%). In particular, there ...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2010.12.014

    authors： Kuzel D,Mara M,Horak P,Kubinova K,Maskova J,Dundr P,Cindr J

    更新日期：2011-05-01 00:00:00

  • Identification of main risk factors for tubal infertility.

    abstract：OBJECTIVE:To determine the relationship between some reproductive variables and infertility caused by tubal obstruction. DESIGN:A retrospective, case-control study. SETTING:A tertiary care university hospital that is a referral center for infertility patients. PARTICIPANTS:Subjects were interviewed between March 199...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Bahamondes L,Bueno JG,Hardy E,Vera S,Pimentel E,Ramos M

    更新日期：1994-03-01 00:00:00

  • Embryo transfer practices and multiple births resulting from assisted reproductive technology: an opportunity for prevention.

    abstract：OBJECTIVE:To evaluate assisted reproductive technology (ART) ET practices in the United States and assess the impact of these practices on multiple births, which pose health risks for both mothers and infants. DESIGN:Retrospective cohort analysis using the National ART Surveillance System data. SETTING:US fertility c...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2014.12.127

    authors： Kissin DM,Kulkarni AD,Mneimneh A,Warner L,Boulet SL,Crawford S,Jamieson DJ,National ART Surveillance System (NASS) group.

    更新日期：2015-04-01 00:00:00

  • Human cumulus cell gene expression as a biomarker of pregnancy outcome after single embryo transfer.

    abstract：OBJECTIVE:To identify the cumulus cell gene expression associated with oocyte developmental competence, specifically live birth, after single ET (SET) assisted reproductive technology. DESIGN:Retrospective gene expression analysis in human cumulus cells from oocytes that established a pregnancy resulting in live birth...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.04.033

    authors： Gebhardt KM,Feil DK,Dunning KR,Lane M,Russell DL

    更新日期：2011-07-01 00:00:00

  • BRCA carriers' thoughts on risk management in relation to preimplantation genetic diagnosis and childbearing: when too many choices are just as difficult as none.

    abstract：:Women with a BRCA mutation have unique concerns about childbearing and future fertility. In a focus group conducted among unaffected carriers, the majority of women held positive attitudes toward preimplantation genetic diagnosis to reduce transmission to future offspring and further identified unmet needs for educati...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.03.064

    authors： Quinn GP,Vadaparampil ST,Tollin S,Miree CA,Murphy D,Bower B,Silva C

    更新日期：2010-11-01 00:00:00

  • Effect of oxidative stress in follicular fluid on the outcome of assisted reproductive procedures.

    abstract：OBJECTIVE(S):To measure levels of lipid peroxidation (LPO) and total antioxidant capacity (TAC) in the follicular fluid from patients undergoing IVF and to examine the association among LPO and TAC and oocyte maturity, embryo quality, fertilization, cleavage, and pregnancy rates. DESIGN:Prospective study. SETTING:Ter...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2003.11.021

    authors： Pasqualotto EB,Agarwal A,Sharma RK,Izzo VM,Pinotti JA,Joshi NJ,Rose BI

    更新日期：2004-04-01 00:00:00

  • Expression of the insulin-like growth factor and insulin systems in the luteinizing macaque ovarian follicle.

    abstract：OBJECTIVE:To determine intrafollicular hormone levels and characterize the mRNA expression of the insulin-like growth factor (IGF) receptors, IGF binding proteins (IGFBP), and pregnancy-associated plasma protein-A (PAPP-A) in granulosa cells before and after an ovulatory hCG stimulus. DESIGN:Experimental animal study....

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.12.096

    authors： Brogan RS,Mix S,Puttabyatappa M,VandeVoort CA,Chaffin CL

    更新日期：2010-03-15 00:00:00

  • Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome.

    abstract：OBJECTIVE:To test by genomic analysis whether empty follicle syndrome (EFS) in a family with two affected sisters has a genetic basis. DESIGN:Whole-exome sequencing in the context of clinical genetics. SETTING:University hospital. PATIENT(S):Two women (36 and 32 years old at the time of the study) with EFS. INTERVE...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.05.057

    authors： Yariz KO,Walsh T,Uzak A,Spiliopoulos M,Duman D,Onalan G,King MC,Tekin M

    更新日期：2011-08-01 00:00:00

  • Hormone therapy use among postmenopausal French women before the publication of the Women's Health Initiative study: duration of use and factors associated with discontinuation.

    abstract：OBJECTIVE:Compliance with recent recommendations concerning hormone therapy (HT) requires that we understand the reasons why women receiving HT continue or stop their treatment. Our aim was to estimate the duration of HT use and analyze factors associated with its discontinuation during the period before the publicatio...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2004.12.040

    authors： Ringa V,Varnoux N,Piault S,Bréart G

    更新日期：2005-06-01 00:00:00

  • Significance of sperm characteristics in the evaluation of male infertility.

    abstract：OBJECTIVE:To compare sperm characteristics among: patients undergoing infertility evaluation, patients with male factor infertility (MFI), healthy sperm donors, and men with proven fertility; to examine the overlap of sperm characteristics in all four of these groups; and to identify good discriminators of fertility ve...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2005.08.024

    authors： Nallella KP,Sharma RK,Aziz N,Agarwal A

    更新日期：2006-03-01 00:00:00

  • Protein O-carboxylmethyltransferase in spermatozoa from normal and infertile men.

    abstract：:In confirmation of several reports, suspensions of normal washed human spermatozoa exposed to a nonionic detergent exhibited considerable activity of the enzyme protein O-carboxylmethyltransferase (PCM), which catalyzes the methyl esterification of carboxyl groups of dicarboxylic amino acid residues in proteins. Vario...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Hatch R,Harvey SE,Williams-Ashman HG

    更新日期：1985-04-01 00:00:00

  • Effective treatment of severe menstrual migraine headaches with gonadotropin-releasing hormone agonist and "add-back" therapy.

    abstract：OBJECTIVE:To determine the efficacy of treating women with severe menstrual migraine headaches with GnRH agonist (GnRH-a) therapy, alone and combined with continuous estrogen-progestin "add-back." DESIGN:Nonrandomized, prospective treatment study. SETTING:Outpatient clinic in a university medical center. PATIENT(S):...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0015-0282(97)81928-0

    authors： Murray SC,Muse KN

    更新日期：1997-02-01 00:00:00

  • Effect of curcumin on aflatoxin-induced biochemical changes in testis of mice.

    abstract：OBJECTIVE:To investigate the effect of curcumin on aflatoxin-induced biochemical changes in testis of mice. DESIGN:Controlled research laboratory study. SETTING:Aflatoxin was obtained by growing Aspergillus parasiticus in SMKY liquid medium. Pure curcumin (97% purity) was purchased from Hi-Media Laboratories Pvt. Ltd...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.11.053

    authors： Verma RJ,Mathuria N

    更新日期：2009-02-01 00:00:00

  • Successful microsurgical removal of a pronucleus from tripronuclear human zygotes.

    abstract：:We have microsurgically extracted a pronucleus from 11 tripronuclear human zygotes under two different experimental conditions. One group of six zygotes was incubated in cytochalasin D for 30 minutes before manipulation. The remaining five zygotes were manipulated without preincubation in cytoskeletal relaxing agents....

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60901-9

    authors： Gordon JW,Grunfeld L,Garrisi GJ,Navot D,Laufer N

    更新日期：1989-09-01 00:00:00

  • International Federation of Fertility Societies Surveillance 2013: preface and conclusions.

    abstract：:Surveillance is a triennial worldwide compendium of national rules and regulations for assisted reproductive technology. It was last published in 2010. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2014.03.045

    authors： Ory SJ,Devroey P,Banker M,Brinsden P,Buster J,Fiadjoe M,Horton M,Nygren K,Pai H,Le Roux P,Sullivan E

    更新日期：2014-06-01 00:00:00

  • Changes in plasma müllerian-inhibiting substance and brain-derived neurotrophic factor after chemotherapy in premenopausal women.

    abstract：:Eight premenopausal women with cancer had blood drawn for analysis of brain-derived neurotrophic factor (BDNF) and müllerian-inhibiting substance (MIS) before and 3 months after receiving chemotherapy. Unlike MIS, BDNF levels were not reduced after chemotherapy. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.10.033

    authors： Aslam MF,Merhi ZO,Ahmed S,Kuzbari O,Seifer DB,Minkoff H

    更新日期：2011-04-01 00:00:00

  • Intrauterine injection of human chorionic gonadotropin before embryo transfer can improve in vitro fertilization-embryo transfer outcomes: a meta-analysis of randomized controlled trials.

    abstract：OBJECTIVE:To evaluate whether intrauterine injection of hCG before embryo transfer can improve IVF-ET outcomes. DESIGN:Meta-analysis. SETTING:Not applicable. PATIENT(S):Infertile women who underwent IVF-ET and received an intrauterine injection of hCG before ET. INTERVENTION(S):Infertile women treated with or witho...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.fertnstert.2019.02.027

    authors： Gao M,Jiang X,Li B,Li L,Duan M,Zhang X,Tian J,Qi K

    更新日期：2019-07-01 00:00:00