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Clinical evaluation of the effects of combined treatment with bromocriptine and spironolactone in two women with the polycystic ovary syndrome.

Abstract：

:Two women with the polycystic ovary syndrome were treated with bromocriptine (15 to 20 mg/day) in combination with spironolactone (100 mg/day). In the first woman the combined therapy induced a marked reduction of hirsutism, with ensuing ovulation and pregnancy. In the second woman, who had hyperthecosis and had been refractory to treatment with clomiphene and wedge resection, the combined therapy resulted in abolition of hirsutism, normalization of blood pressure, weight reduction, and improvement in glucose intolerance. In this patient fertility could not be established by the above treatment, but the symptomatic amelioration was so great that she accepted no further attempt to induce ovulation. In view of the marked amelioration of the polycystic ovary syndrome induced by combined bromocriptine and spironolactone treatment, this mode of therapy should receive further consideration.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Blum I,Bruhis S,Kaufman H

doi

10.1016/s0015-0282(16)45554-8

subject

Has Abstract

pub_date

1981-06-01 00:00:00

pages

629-33

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)45554-8

journal_volume

35

pub_type

杂志文章

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