当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Use of gonadotropin-releasing hormone agonist trigger during in vitro fertilization is associated with similar endocrine profiles and oocyte measures in women with and without polycystic ovary syndrome.

Use of gonadotropin-releasing hormone agonist trigger during in vitro fertilization is associated with similar endocrine profiles and oocyte measures in women with and without polycystic ovary syndrome.

Abstract：

OBJECTIVE:To compare endocrine profiles and IVF outcomes after using GnRH agonists (GnRHa) to trigger final oocyte maturation in women with polycystic ovary syndrome (PCOS) with other hyper-responders. DESIGN:Retrospective cohort study. SETTING:Academic center. PATIENT(S):Forty women with PCOS and 74 hyper-responders without PCOS. INTERVENTION(S):GnRHa trigger. MAIN OUTCOME MEASURE(S):Number of oocytes. RESULT(S):Serum E2, LH, and P levels on the day of GnRHa trigger and the day after trigger did not differ significantly between groups. There were no significant differences in total number of oocytes or percent mature oocytes obtained between groups after controlling for age, antral follicle count, and total days of stimulation. The overall rate of no retrieval of oocytes after trigger was low (2.6%). Fertilization, implantation, clinical pregnancy, and live-birth rates were similar in the two groups. No patients developed ovarian hyperstimulation syndrome (OHSS). CONCLUSION(S):The similar post-GnRHa trigger hormone profiles and mature oocyte yield support the routine use of GnRHa trigger to prevent OHSS in women with PCOS.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

O'Neill KE,Senapati S,Dokras A

doi

10.1016/j.fertnstert.2014.09.042

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

264-9

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(14)02224-9

journal_volume

103

pub_type

杂志文章

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