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The adverse effect of hydrosalpinges on in vitro fertilization pregnancy rates and the benefit of surgical correction.

Abstract：

OBJECTIVE:To test the hypothesis that IVF-ET pregnancy rates (PRs) for patients with tubal factor infertility are decreased in patients with hydrosalpinges and that surgical correction reverses this effect. DESIGN:Retrospective chart review. SETTING:Private practice IVF-ET program. PATIENT(S):Patients (n = 160) undergoing 238 cycles of IVF-ET were stratified into groups based on the presence of hydrosalpinges and whether surgical correction had been performed. Patients >39 years old and patients with male factor infertility were excluded from the study. INTERVENTION(S):Patients with hydrosalpinges were offered surgical correction. MAIN OUTCOME MEASURE(S):Clinical pregnancy defined by an intrauterine gestational sac. RESULT(S):Patients with hydrosalpinges had significantly decreased implantation rates and PRs per transfer (2.8% and 8.5%, respectively) than patients with tubal factor infertility but without hydrosalpinges (15.7% and 38.6%). Surgical correction improved implantation rates and PRs in patients with prior failed cycles (16.1% and 37.5%) and in patients undergoing surgery before IVF-ET (21.8% and 51.7%). The type of surgery performed did not affect success rates in the small number of patients evaluated. CONCLUSION(S):The presence of a hydrosalpinx during an IVF-ET cycle results in significant decreases in implantation rates and PRs. Surgical treatment of hydrosalpinges before IVF-ET cycles improves implantation rates and PRs.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Murray DL,Sagoskin AW,Widra EA,Levy MJ

doi

10.1016/s0015-0282(97)00447-0

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

41-5

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015028297004470

journal_volume

69

pub_type

杂志文章,评审

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