当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Induction of menstruation by an antiprogesterone steroid (RU 486) in primates: site of action, dose-response relationships, and hormonal effects.

Induction of menstruation by an antiprogesterone steroid (RU 486) in primates: site of action, dose-response relationships, and hormonal effects.

Abstract：

:The antiprogesterone compound RU 486 (17 beta-hydroxy-11 beta-[4-dimethylaminophenyl]-17 alpha-[ 1-propynyl]estra-4,9-dien-3-one; Roussel-Uclaf, Paris, France) was used to induce menstruation in a randomized controlled trial. Castrated adult female cynomolgus monkeys (n = 17) received sequential subcutaneous Silastic capsules of estradiol or progesterone over a 49-day regimen which stimulated the steroidal milieu of the fertile ovarian/menstrual cycle. RU 486 was injected at 10.0, 1.0 to 3.0, or 0.1 mg/kg from days 31 to 34 of this protocol. At all concentrations tested, menstruation followed RU 486 injection within 48 hours and persisted through 72 hours. No bleeding followed placebo injections. All monkeys that menstruated after RU 486 administration also manifested vaginal bleeding after removal of exogenous steroid treatments. No changes in daily serum follicle-stimulating hormone, luteinizing hormone, prolactin, or serum and urinary free cortisol accompanied RU 486 treatment. We conclude that (1) RU 486 promptly induces menstruation by a local action upon the endometrium; (2) familiar endometrial proliferation and withdrawal bleeding can redevelop after exposure to this compound; (3) no effects of RU 486 on serum cortisol or pituitary gonadotropins were noted; and (4) extensive combination therapy with estrogen and progesterone causes mild hyperprolactinemia.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Healy DL,Baulieu EE,Hodgen GD

doi

10.1016/s0015-0282(16)47246-8

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

253-7

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)47246-8

journal_volume

40

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Protein expression profiling of endometriosis: validation of 2-mm tissue microarrays.

    abstract：:Tissue microarrays (TMAs) are useful tools for studying protein expression in endometriosis. Tissue microarray analyses of immunohistochemical profiles of estrogen receptor-alpha and P receptor corroborate previously published results from the use of conventional immunohistochemistry, thus validating TMA use in endome...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2004.06.044

    authors： Kamat AA,Younes PS,Sayeeduddin M,Wheeler TM,Simpson JL,Agoulnik AI

    更新日期：2004-12-01 00:00:00

  • Selective insulin-like growth factor-I antagonist inhibits mouse embryo development in a dose-dependent manner.

    abstract：OBJECTIVE:To study the role of a synthetic insulin-like growth factor-I receptor (IGF-IR) antagonist, picropodophyllin, for mouse preimplantation embryo development in vivo and in vitro. DESIGN:In vitro and in vivo study. SETTING:Hospital-based research unit. ANIMALS:FVB/N mice and mouse embryos. INTERVENTION(S):Th...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.12.044

    authors： Inzunza J,Danielsson O,Lalitkumar PG,Larsson O,Axelson M,Töhönen V,Danielsson KG,Stavreus-Evers A

    更新日期：2010-05-15 00:00:00

  • The effect of the new 2010 World Health Organization criteria for semen analyses on male infertility.

    abstract：OBJECTIVE:To quantify the effect of the new 2010 World Health Organization (WHO) semen analysis reference values on reclassifying previous semen analysis parameters and definition of patients with male factor infertility. DESIGN:A multi-institutional retrospective chart review. SETTING:University and private male inf...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.07.1130

    authors： Murray KS,James A,McGeady JB,Reed ML,Kuang WW,Nangia AK

    更新日期：2012-12-01 00:00:00

  • Early prediction of ovarian multifollicular response during ovulation induction in patients with polycystic ovary syndrome.

    abstract：OBJECTIVE:To examine the association between the midfollicular FSH-LH ratio and the number of follicles, and the multifollicular ovarian response to gonadotropin stimulation in patients with polycystic ovary syndrome (PCOS) with normal basal LH and FSH levels. SUBJECT(S):Eighteen patients who had an abandoned treatmen...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)80069-6

    authors： Farhi J,Jacobs HS

    更新日期：1997-03-01 00:00:00

  • Digital road mapping image--a novel fluoroscopic real-time guide for selective transcervical catheterization in the treatment of proximal tubal obstruction.

    abstract：:Ten infertile women 20 to 40 years of age, with a standard HSG diagnosis of unilateral proximal tubal obstruction, underwent a transvaginal catheterization and recanalization of the fallopian tubes. To set a fluoroscopic real-time guidance technique for improving the results of transvaginal catheterization and recanal...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)55344-8

    authors： Eckstein N,Orron DE,Vagman I,Papo J,Lidor A,Chen Z,Ayalon D

    更新日期：1992-10-01 00:00:00

  • Antimüllerian hormone is reduced in the presence of ovarian endometriomas: a systematic review and meta-analysis.

    abstract：OBJECTIVE:To evaluate if the presence of endometriomas impacts on the ovarian reserve as evaluated with antimüllerian hormone (AMH). DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENT(S):Patients with unoperated endometriomas versus controls without endometriomas. INTERVENTION(S):Electronic...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.fertnstert.2018.06.025

    authors： Muzii L,Di Tucci C,Di Feliciantonio M,Galati G,Di Donato V,Musella A,Palaia I,Panici PB

    更新日期：2018-10-01 00:00:00

  • Use of gonadotropin-releasing hormone agonists in patients with Hodgkin's disease for preservation of ovarian function and reduction of gonadotoxicity related to chemotherapy.

    abstract：:In young women receiving chemotherapy for Hodgkin's disease, the combined use of triptorelin and tibolone cotreatment may be a useful tool for preserving ovarian function because all but three (10%) of the women in this treatment group returned to spontaneous ovulation and menses, in contrast to 23% of subjects in the...

    journal_title：Fertility and sterility

    pub_type： 信件

    doi：10.1016/j.fertnstert.2006.10.004

    authors： Castelo-Branco C,Nomdedeu B,Camus A,Mercadal S,Martínez de Osaba MJ,Balasch J

    更新日期：2007-03-01 00:00:00

  • Effect of rosiglitazone on spontaneous and clomiphene citrate-induced ovulation in women with polycystic ovary syndrome.

    abstract：OBJECTIVE:In women suffering from polycystic ovary syndrome (PCOS), correction of hyperinsulinemia results enhances spontaneous ovulation or alternatively, the responsiveness to ovulation induction agents such as clomiphene citrate (CC). We investigated the effect of rosiglitazone maleate on ovulation induction in over...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(02)04843-4

    authors： Ghazeeri G,Kutteh WH,Bryer-Ash M,Haas D,Ke RW

    更新日期：2003-03-01 00:00:00

  • Assessing the role of endometrial alteration among obese patients undergoing assisted reproduction.

    abstract：:Obesity seems to exert a small but important extraovarian effect that may influence cycle outcome during assisted reproduction. Future investigation should focus on elucidating whether the endometrium is truly responsible for this deficit, and if it is, determining the mechanisms involved. ...

    journal_title：Fertility and sterility

    pub_type： 评论,杂志文章

    doi：10.1016/j.fertnstert.2007.03.079

    authors： Levens ED,Skarulis MC

    更新日期：2008-06-01 00:00:00

  • Gonadotropin-releasing hormone antagonist use is associated with increased pregnancy rates in ovulation induction-intrauterine insemination to in vitro fertilization conversions, independent of age and estradiol level on the day of human chorionic gonadot

    abstract：OBJECTIVE:To determine whether the use of GnRH antagonist in cycles converted from ovulation induction-IUI to IVF affects cycle outcome and pregnancy rates. DESIGN:Retrospective cohort study. SETTING:Academic research institution. PATIENT(S):One hundred eighty-two consecutive patients with ovulation induction-IUI to...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.01.109

    authors： Quaas AM,Missmer SA,Ginsburg ES

    更新日期：2010-02-01 00:00:00

  • Cyclic changes in the concentration of glucose and fructose in human cervical mucus.

    abstract：OBJECTIVE:To determine a possible cyclic change in the concentration of glucose and fructose in the aqueous phase of human cervical mucus (CM). DESIGN:Concentrations of glucose and fructose were longitudinally determined in the aqueous phase of CM of normal cycling women using enzymatic techniques, modified for small ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54902-4

    authors： van der Linden PJ,Kets M,Gimpel JA,Wiegerinck MA

    更新日期：1992-03-01 00:00:00

  • Effects of aging on menstrual cycle hormones and endometrial maturation.

    abstract：OBJECTIVE:To investigate changes in menstrual cycle hormones and endometrial maturation that may contribute to the decline in fertility with aging. DESIGN:Prospective controlled clinical study. SETTING:Normal human volunteers in an academic research institution. SUBJECTS:Women with regular menstrual cycles. INTERVE...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Batista MC,Cartledge TP,Zellmer AW,Merino MJ,Axiotis C,Bremner WJ,Nieman LK

    更新日期：1995-09-01 00:00:00

  • Interleukin-1beta and interleukin-1alpha may affect the implantation rate of patients undergoing in vitro fertilization-embryo transfer.

    abstract：OBJECTIVE:To investigate whether interleukin-1beta (IL-1beta) and interleukin-1alpha (IL-1alpha) affect the implantation rate of patients undergoing IVF-ET. DESIGN:Follicular fluid and serum were obtained on the day of hCG administration, the day of oocyte retrieval, and the day of embryo transfer. SETTING:Cellular i...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(98)00243-x

    authors： Karagouni EE,Chryssikopoulos A,Mantzavinos T,Kanakas N,Dotsika EN

    更新日期：1998-09-01 00:00:00

  • Assessment of female sexual dysfunction: review of validated methods.

    abstract：OBJECTIVE:To review validated methods for the assessment of female sexual function in clinical trials. DESIGN:Evaluation of recent peer-review literature on sexual function assessment in women. SETTING:International conference on androgen insufficiency in women. PATIENT(S):Women with sexual dysfunction due to androg...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/s0015-0282(02)02966-7

    authors： Rosen RC

    更新日期：2002-04-01 00:00:00

  • How do patients choose private in vitro fertilization treatment? A customer survey in a tertiary fertility center in the United Kingdom.

    abstract：OBJECTIVE:To assess the relevant factors affecting patients' decision when choosing a clinic for private, self-funded IVF treatment. DESIGN:Prospective anonymous closed questionnaires. SETTING:Single tertiary-care private IVF center. PATIENT(S):New patients attending primary consultation in a period of 7 months from...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)01751-4

    authors： Lass A,Brinsden P

    更新日期：2001-05-01 00:00:00

  • Growth hormone cotreatment for poor responders undergoing in vitro fertilization cycles: a systematic review and meta-analysis.

    abstract：OBJECTIVE:To evaluate the effectiveness of growth hormone (GH) supplementation in improving the in vitro fertilization (IVF) outcomes of poor responders. DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENT(S):Poor ovarian responders undergoing conventional IVF or intracytoplasmic sperm inject...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2020.03.007

    authors： Cozzolino M,Cecchino GN,Troiano G,Romanelli C

    更新日期：2020-07-01 00:00:00

  • Hyperreactio luteinalis with both markedly elevated human chorionic gonadotropin levels and an imbalance of angiogenic factors subsequently developed severe early-onset preeclampsia.

    abstract：OBJECTIVE:To report a case of hyperreactio luteinalis (HL) with elevated levels of human chorionic gonadotropin (hCG) and a severe imbalance of angiogenic factors, which developed into severe, early onset preeclampsia (PE). DESIGN:Case report. SETTING:University perinatal center. PATIENT(S):A 32-year-old primigravid...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.04.002

    authors： Masuyama H,Tateishi Y,Matsuda M,Hiramatrsu Y

    更新日期：2009-07-01 00:00:00

  • Impact of reproductive history on in vitro fertilization and intracytoplasmic sperm injection outcome: evidence from the German IVF Registry.

    abstract：OBJECTIVE:To evaluate the effect of reproductive history on the outcome of different procedures in assisted reproductive technologies (ART) comparing IVF, ICSI, and cryopreserved embryo transfer (CPE). DESIGN:Prospective registration of ART cycles and their outcomes. SETTING:One hundred three reproductive programs in...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(03)00760-x

    authors： Kupka MS,Dorn C,Richter O,Felberbaum R,van der Ven H

    更新日期：2003-09-01 00:00:00

  • Increases in progesterone after human chorionic gonadotropin administration may predict cycle outcome in patients undergoing in vitro fertilization-embryo transfer.

    abstract：:In this study, both IVF-ET cycle and pregnancy outcome were compared with increases seen in P concentration during the 24-hour period from 12 hours before to 12 hours after hCG administration. A significantly higher PR (P < 0.001) was seen in women who had at least a threefold increase in P during this time period. Fu...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Prien SD,Canez MS,Messer RH

    更新日期：1994-11-01 00:00:00

  • Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the azoospermic subject.

    abstract：OBJECTIVE:To investigate whether testicular cytology by fine needle aspiration (FNA) may be considered a diagnostic parameter in the evaluation of the azoospermic subject. DESIGN:Cytologic smears were obtained using a 23-G needle, stained with May-Grünwald-Giemsa stain and examined under a light Orthoplan microscope (...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54971-1

    authors： Foresta C,Varotto A,Scandellari C

    更新日期：1992-04-01 00:00:00

  • Reinsemination by intracytoplasmic sperm injection of 1-day-old oocytes after complete conventional fertilization failure.

    abstract：OBJECTIVE:To analyze the efficacy of intracytoplasmic sperm injection (ICSI) for "rescue" of failed conventional insemination cycles. DESIGN:Retrospective clinical study. SETTING:Private infertility clinic. PATIENT(S):Fifty-four couples with non-male factor infertility undergoing routine IVF within our clinic. INTE...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)00223-9

    authors： Morton PC,Yoder CS,Tucker MJ,Wright G,Brockman WD,Kort HI

    更新日期：1997-09-01 00:00:00

  • Case of sisters with complete androgen insensitivity syndrome and discordant Müllerian remnants.

    abstract：OBJECTIVE:Presentation of complete androgen insensitivity in two members of the same family with differing residual Müllerian tissue. DESIGN:Case report. SETTING:Rural hospital setting. PATIENT(S):Two siblings with 46,XY karyotype and female phenotype presented at different points in time with primary amenorrhea. La...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.09.027

    authors： Nichols JL,Bieber EJ,Gell JS

    更新日期：2009-03-01 00:00:00

  • Spontaneous pregnancy during the infertility evaluation.

    abstract：:Of 299 patients evaluated for infertility between July 1, 1974, and December 31, 1976, 21 (7.2%) became pregnant during the initial evaluation prior to any recognized therapy. A comparative analysis was made between these 21 couples and the 223 completely evaluated infertility couples. No significant difference in sex...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Drake TS,Tredway DR

    更新日期：1978-07-01 00:00:00

  • Microsurgical transplantation of nonvascularized segments of the fallopian tube in the rabbit.

    abstract：:Microsurgical nonvascularized transplantation of a 1-cm segment of fallopian tube was performed using the rabbit as a model. Autograft experiments showed survival of a 1-cm tubal segment for as long as 10 months postoperatively. Allografts survived equally as well, and one rabbit became pregnant. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)45691-8

    authors： Stangel JJ,Davidian MM,Wenof M,Barber HR

    更新日期：1981-08-01 00:00:00

  • Comparison of embryo morphokinetics after in vitro fertilization-intracytoplasmic sperm injection in smoking and nonsmoking women.

    abstract：OBJECTIVE:To evaluate the impact of female smoking on early embryo development in vitro using a time-lapse system. DESIGN:Retrospective analysis of prospectively collected database. SETTING:Assisted reproductive technology (ART) program. PATIENT(S):A total of 135 infertile couples undergoing IVF-intracytoplasmic spe...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2013.01.136

    authors： Fréour T,Dessolle L,Lammers J,Lattes S,Barrière P

    更新日期：2013-06-01 00:00:00

  • A mechanism for integrated health care is ideal for women with primary ovarian insufficiency.

    abstract：:It is clear that women with primary ovarian insufficiency are asking the health care community to alter the current standard, which requires the patient to seek a different specialist for each of her health care needs, and instead work as a team of caregivers that embraces each patient as a woman with complex and indi...

    journal_title：Fertility and sterility

    pub_type： 评论,杂志文章

    doi：10.1016/j.fertnstert.2011.03.006

    authors： Sullivan SD

    更新日期：2011-05-01 00:00:00

  • Functional differentiation in progesterone secretion by granulosa versus cumulus cells in the human preovulatory follicle and the effect of different induction of ovulation protocols.

    abstract：OBJECTIVE:To investigate P secretion by granulosa cells (GCs) versus cumulus cells derived from human preovulatory follicles. DESIGN:Cells were recovered by aspiration of preovulatory follicles in 44 women participating in an IVF program. Induction of ovulation was performed using clomiphene citrate, hMG and hCG (grou...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56404-8

    authors： Dirnfeld M,Goldman S,Gonen Y,Koifman M,Lissak A,Kraiem Z,Abramovici H

    更新日期：1993-12-01 00:00:00

  • Influence of severe endometriosis on gene expression of vascular endothelial growth factor and interleukin-6 in granulosa cells from patients undergoing controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer.

    abstract：OBJECTIVE:To evaluate how endometriosis affects expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in granulosa cells. DESIGN:Prospective study. SETTING:IVF-ET program at Osaka Medical College. PATIENT(S):Seventeen patients with revised American Fertility Society stage IV endometriosis ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)03339-3

    authors： Yamashita Y,Ueda M,Takehara M,Yamashita H,Suzuki Y,Hung YC,Terai Y,Ueki M

    更新日期：2002-10-01 00:00:00

  • Relationship and parenthood in IVF couples with twin and singleton pregnancies compared with spontaneous singleton primiparous couples--a prospective 5-year follow-up study.

    abstract：OBJECTIVE:To analyze relationship and parenthood in IVF twin couples, IVF singleton couples, and spontaneously pregnant primiparous couples. SETTING:Southeast region of Sweden. DESIGN:Prospective case-control study. PATIENT(S):In total, 24 women and men who became pregnant with twins, consecutively, and expected the...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.03.064

    authors： Sydsjö G,Wadsby M,Sydsjö A,Selling KE

    更新日期：2008-03-01 00:00:00

  • Forty years of IVF.

    abstract：:This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field. ...

    journal_title：Fertility and sterility

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.fertnstert.2018.06.005

    authors： Niederberger C,Pellicer A,Cohen J,Gardner DK,Palermo GD,O'Neill CL,Chow S,Rosenwaks Z,Cobo A,Swain JE,Schoolcraft WB,Frydman R,Bishop LA,Aharon D,Gordon C,New E,Decherney A,Tan SL,Paulson RJ,Goldfarb JM,Brännström

    更新日期：2018-07-15 00:00:00