当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > The effect of gonadotropin-releasing hormone agonist on the ovarian response and in vitro fertilization results in polycystic ovarian syndrome: a prospective study.

The effect of gonadotropin-releasing hormone agonist on the ovarian response and in vitro fertilization results in polycystic ovarian syndrome: a prospective study.

Abstract：

OBJECTIVE:To assess the effect of gonadotropin-releasing hormone agonist (GnRH-a) on pituitary suppression, subsequent ovarian response, and results of in vitro fertilization (IVF) treatments in polycystic ovarian syndrome (PCOS) patients. DESIGN:Randomized prospective study. SETTING:In vitro fertilization program and endocrinologic institute. PATIENTS:Thirty patients with PCOS; 16 received GnRH-a, and 14 did not receive GnRH-a. INTERVENTIONS:Ovum pick-up and embryo transfer. MAIN OUTCOME MEASURES:Response to GnRH-a test, serum and follicular fluid (FF) hormonal measurements, steroid levels, and aromatse activity in granulosa cell (GC) culture, and results of IVF. RESULTS:Pituitary responsiveness was abolished in all patients 14 days after GnRH-a administration, and early luteinization was prevented. Steroid levels in FF did not differ between the two groups. In GC culture, progesterone (P) levels were higher in patients without the GnRH-a (3,704 +/- 1,232 nmol/L versus 2,117 +/- 235 nmol/L; P less than 0.05) as were androstenedione (A) levels (5.3 +/- 1.0 nmol/L versus less than 3.5 nmol/L; P less than 0.05). However, aromatase activity and IVF results were similar in the two groups. CONCLUSIONS:Administration of GnRH-a in patients with PCOS decreases P and A production by the GC cells and prevents early luteinization. It does not affect the IVF results.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Dor J,Shulman A,Pariente C,Levran D,Bider D,Menashe Y,Mashiach S

doi

10.1016/s0015-0282(16)54847-x

keywords:

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

366-71

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54847-X

journal_volume

57

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Transcervical placement of a Malecot catheter after hysteroscopic evaluation provides for easier entry into the endometrial cavity for women with histories of difficult intrauterine inseminations and/or embryo transfers: a prospective case series.

    abstract：OBJECTIVE:To evaluate a new technique designed to improve access to the endometrial cavity through tortuous and/or stenotic endocervical canals in women with histories of difficult IUIs, ETs, or endometrial biopsies. DESIGN:Prospective case series. SETTING:Tertiary care center. PATIENT(S):Women with histories of dif...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(99)00492-6

    authors： Yanushpolsky EH,Ginsburg ES,Fox JH,Stewart EA

    更新日期：2000-02-01 00:00:00

  • Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility.

    abstract：OBJECTIVE:Determine whether peritoneal macrophages from women with endometriosis-associated infertility express more inducible nitric oxide synthase (NOS2) and produce more NO than fertile controls. DESIGN:Unblinded clinical study. PATIENT(S):Nine infertile women with endometriosis and nine normal fertile women under...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)02940-5

    authors： Osborn BH,Haney AF,Misukonis MA,Weinberg JB

    更新日期：2002-01-01 00:00:00

  • Trial development of the Cognitive Appraisal Scale for Infertility (CASI) (version 1).

    abstract：OBJECTIVE:To develop the Cognitive Appraisal Scale for Infertility (CASI) and assess it for reliability and validity. DESIGN:Cross-sectional and longitudinal study. SETTING:A private fertility institute in Japan. PATIENT(S):223 infertile women being treated at the institute. INTERVENTION(S):Administration of questi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.03.052

    authors： Saito Y,Matsuo H

    更新日期：2009-06-01 00:00:00

  • A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy.

    abstract：:Eighteen premenopausal women with symptomatic leiomyomata uteri were enrolled in a stratified, randomized, double-blind, placebo-controlled study evaluating the efficacy of leuprolide acetate (LA) depot treatment before myomectomy. Stratification was based on pretreatment uterine volume (less than 600 cm3 versus great...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Friedman AJ,Rein MS,Harrison-Atlas D,Garfield JM,Doubilet PM

    更新日期：1989-11-01 00:00:00

  • Clomiphene citrate in the management of infertility associated with shortened luteal phases.

    abstract：:Repetitively short luteal phases were found in eight infertile women. The short luteal phase was defined as 10 days or less from the presumed time of ovulation (as assessed by basal body temperature recording) to the onset of menses. Clomiphene citrate (Clomid) therapy resulted in pregnancy in two patients and lengthe...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(16)43930-0

    authors： Quagliarello J,Weiss G

    更新日期：1979-04-01 00:00:00

  • Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antag

    abstract：OBJECTIVE:To investigate relations between dose of GnRH antagonist and follicular phase characteristics. DESIGN:Randomized controlled multicenter trial. SETTING:Tertiary referral fertility centers. PATIENT(S):Three hundred and twenty-nine IVF patients. INTERVENTION(S):Ovarian stimulation for IVF with recombinant FS...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0015-0282(00)01789-1

    authors： de Jong D,Macklon NS,Eijkemans MJ,Mannaerts BM,Coelingh Bennink HJ,Fauser BC,Ganirelix Dose-Finding Study Group.

    更新日期：2001-04-01 00:00:00

  • Internal spermatic vein prostaglandins in varicocele patients.

    abstract：:Blood was collected from 20 patients with varicocele (15 in the infertile group and 5 in the incidental varicocele group) at the time of high ligation by insertion of a catheter into the internal spermatic vein toward the renal side. Simultaneously, blood was obtained from the antecubital vein. The levels of cortisol,...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)46043-7

    authors： Ito H,Fuse H,Minagawa H,Kawamura K,Murakami M,Shimazaki J

    更新日期：1982-02-01 00:00:00

  • Elevated serum estradiol associated with increased androstenedione-testosterone ratio in adolescent males with varicocele and gynecomastia.

    abstract：OBJECTIVE:To investigate the testicular function in adolescents with pubertal gynecomastia associated with varicocele before and after varicocelectomy. DESIGN AND PATIENTS:We have studied six male adolescents 15 to 19 years of age with bilateral gynecomastia. They were selected among other adolescents with gynecomasti...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54551-8

    authors： Castro-Magana M,Angulo M,Uy J

    更新日期：1991-09-01 00:00:00

  • Advanced follicle development in xenografted prepubertal ovarian tissue: the common marmoset as a nonhuman primate model for ovarian tissue transplantation.

    abstract：OBJECTIVE:To establish a nonhuman primate model addressing follicular development in cryopreserved prepubertal ovarian tissue after xenografting. DESIGN:Experimental study. SETTING:Academic research center. ANIMAL(S):Ovarian tissue from female prepubertal common marmoset (Callytrix jacchus jacchus) grafted into immu...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.11.003

    authors： von Schönfeldt V,Chandolia R,Kiesel L,Nieschlag E,Schlatt S,Sonntag B

    更新日期：2011-03-15 00:00:00

  • Hysterectomy performed within 1 year after tubal sterilization.

    abstract：:In the United States, approximately 650,000 women of reproductive age undergo tubal sterilization each year and some of these women later have hysterectomies. Little is known about risk factors for having hysterectomy after tubal sterilization. For examination of this issue, we analyzed data from the Collaborative Rev...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)48974-0

    authors： Kendrick JS,Rubin GL,Lee NC,Schulz KF,Peterson HB,Nolan TF

    更新日期：1985-11-01 00:00:00

  • Survival of the cornual pregnancy in a heterotopic gestation after in vitro fertilization and embryo transfer.

    abstract：:We present a case of combined intrauterine and cornual (interstitial) pregnancy after IVF-ET, with survival of the infant after the cornual pregnancy. The diagnosis of this rare phenomenon is difficult; a high index of suspicion and frequently ultrasound monitoring may enable early diagnosis in other forms of heteroto...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)53473-6

    authors： Beck P,Silverman M,Oehninger S,Muasher SJ,Acosta AA,Rosenwaks Z

    更新日期：1990-04-01 00:00:00

  • Higher chromosomal aberration rate in miscarried conceptus from polycystic ovary syndrome women undergoing assisted reproductive treatment.

    abstract：OBJECTIVE:To assess the potential association between polycystic ovary syndrome (PCOS) and chromosomally aberrant miscarriage during treatment with assisted reproductive technology (ART). DESIGN:A retrospective, single-center study. SETTING:University-affiliated reproductive center. PATIENT(S):A total of 328 patient...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2019.01.026

    authors： Li Y,Wang L,Xu J,Niu W,Shi H,Hu L,Zhang Y,Zhang M,Bao X,Zhang N,Sun Y

    更新日期：2019-05-01 00:00:00

  • Spontaneous heterotopic triplets: a case report.

    abstract：OBJECTIVE:To present a case report of a spontaneous, heterotopic, triplet conception of a patient without any risk factors. DESIGN:Case report. SETTING:Community hospital in Park Ridge, Illinois. PATIENT(S):One patient, 30-year-old multigravida, sent to the emergency room for evaluation of right lower quadrant pain ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.12.034

    authors： Cholkeri-Singh A,LaBarge A

    更新日期：2007-10-01 00:00:00

  • Percutaneous vasal sperm aspiration and intrauterine insemination for infertile males with anejaculation.

    abstract：OBJECTIVE:To explore the effectiveness of percutaneous vasal sperm aspiration (PVSA) in combination with intrauterine insemination (IUI) to treat infertile men with anejaculation. DESIGN:Clinical study. SETTING:Department of reproductive endocrinology and andrology of a family planning research clinic. PATIENT(S):Tw...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)04697-6

    authors： Qiu Y,Wang SM,Yang DT,Wang LG

    更新日期：2003-03-01 00:00:00

  • Human oviductal fluid proteins. III. Identification and partial purification.

    abstract：:The role of the macromolecular constituents of human oviductal fluid (hOF) in reproductive physiology is poorly understood. Oviductal fluid contains proteins derived by transudation from serum and those synthesized and secreted by the tubal mucosa. In this communication, we describe purification of hOF-specific protei...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60433-8

    authors： Wagh PV,Lippes J

    更新日期：1989-01-01 00:00:00

  • Growth factor effects on endometrial epithelial cell differentiation and protein synthesis in vitro.

    abstract：OBJECTIVE:To develop a baseline for projected studies of a rat endometriosis model. DESIGN:We investigated the effects of two macrophage-related growth factors, platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta), on proliferation, in vitro differentiation, and protein secretion of ute...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Whitworth CM,Mulholland J,Dunn RC,Glasser SR

    更新日期：1994-01-01 00:00:00

  • Two cases of cholestasis in the first trimester of pregnancy after ovarian hyperstimulation.

    abstract：OBJECTIVE:To report two cases of early onset cholestasis of pregnancy associated with IVF and ovarian hyperstimulation syndrome. DESIGN:Case report. SETTING:University-based IVF program. PATIENT(S):Two patients with first-trimester cholestasis of pregnancy after IVF that was associated with ovarian hyperstimulation ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.08.072

    authors： Zamah AM,El-Sayed YY,Milki AA

    更新日期：2008-10-01 00:00:00

  • Follicle-stimulating hormone receptor gene mutations are rare in Japanese women with premature ovarian failure and polycystic ovary syndrome.

    abstract：OBJECTIVE:To determine whether the known inactivating FSH receptor gene mutations are present in Japanese women with secondary amenorrhea because of premature ovarian failure (POF) and polycystic ovary syndrome (PCOS). DESIGN:Clinical and molecular studies. SETTING:An outpatient clinic in a university hospital. PATI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(00)01673-3

    authors： Takakura K,Takebayashi K,Wang HQ,Kimura F,Kasahara K,Noda Y

    更新日期：2001-01-01 00:00:00

  • Successful microsurgical removal of a pronucleus from tripronuclear human zygotes.

    abstract：:We have microsurgically extracted a pronucleus from 11 tripronuclear human zygotes under two different experimental conditions. One group of six zygotes was incubated in cytochalasin D for 30 minutes before manipulation. The remaining five zygotes were manipulated without preincubation in cytoskeletal relaxing agents....

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60901-9

    authors： Gordon JW,Grunfeld L,Garrisi GJ,Navot D,Laufer N

    更新日期：1989-09-01 00:00:00

  • Terminology and core curricula in natural family planning.

    abstract：:22 physician-providers who serve natural family planning (NFP) programs, mostly in the private sector, gathered to formulate a standard terminology for the field. The Billings and sympto-thermal methods are the 2 methods taught by this group. The sypto-thermal method helps a woman predict ovulation by detecting chan...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)46409-5

    authors： Brennan JJ,Klaus H

    更新日期：1982-07-01 00:00:00

  • Impact of right-left differences in ovarian morphology on the ultrasound diagnosis of polycystic ovary syndrome.

    abstract：OBJECTIVE:To assess right-left differences in ultrasonographic markers of ovarian morphology and determine the impact on the diagnosis of polycystic ovarian morphology (PCOM). DESIGN:A cross-sectional study of data collected from 2006 to 2018. SETTING:Academic clinical research centers. PATIENT(S):Women with polycys...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.fertnstert.2019.06.016

    authors： Jarrett BY,Vanden Brink H,Brooks ED,Hoeger KM,Spandorfer SD,Pierson RA,Chizen DR,Lujan ME

    更新日期：2019-11-01 00:00:00

  • Using semen flow cytometry to evaluate association of ploidy status and chromatin condensation of spermatozoa with conventional semen parameters: clinical application in intrauterine insemination.

    abstract：OBJECTIVE:To evaluate the association between the ploidy status and the nuclear chromatin condensation of spermatozoa with conventional semen parameters by using semen flow cytometry (SFC). The prognostic value of SFC on the successful outcome of intrauterine insemination (IUI) was examined. DESIGN:Prospective study. ...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2010.05.012

    authors： Lazaros L,Kaponis A,Vartholomatos G,Hatzi E,Botsari S,Plachouras N,Makrydimas G,Zikopoulos K,Sofikitis N,Georgiou I

    更新日期：2011-01-01 00:00:00

  • Pseudoaneurysm of the uterine artery after laparoscopic myomectomy.

    abstract：OBJECTIVE:To describe a case of uterine pseudoaneurysm after laparoscopic myomectomy in a 36-year-old woman. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 36-year-old woman, 3 months after laparoscopic myomectomy, presenting with an intrauterine hypoechoic lesion measuring 5 cm in diameter. INTERVEN...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.09.019

    authors： Asai S,Asada H,Furuya M,Ishimoto H,Tanaka M,Yoshimura Y

    更新日期：2009-03-01 00:00:00

  • Declining estimates of infertility in the United States: 1982-2002.

    abstract：OBJECTIVE:To determine if the decline in infertility has been uniform across subgroups. DESIGN:Periodic data from the National Fertility Survey and the National Survey of Family Growth were used to determine which factors contributed to the decline in 12-month infertility in the United States. SETTING:National Survey...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.02.129

    authors： Stephen EH,Chandra A

    更新日期：2006-09-01 00:00:00

  • Inhibin and relaxin concentrations in early singleton, multiple, and failing pregnancy: relationship to gonadotropin and steroid profiles.

    abstract：OBJECTIVE:To examine the inter-relationships between inhibin, relaxin, steroid concentrations, estradiol (E2), progesterone (P), and gonadotropins in early pregnancy. DESIGN:Hormone concentrations in plasma were measured during the luteal phase of subjects who became pregnant (n = 58) or failed to become pregnant (n =...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)55628-3

    authors： Norman RJ,McLoughlin JW,Borthwick GM,Yohkaichiya T,Matthews CD,MacLennan AH,de Kretser DM

    更新日期：1993-01-01 00:00:00

  • Dual color fluorescence in situ hybridization to investigate aneuploidy in sperm from 33 normal males and a man with a t(2;4;8)(q23;q27;p21)

    abstract：OBJECTIVE:To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence in situ hybridization and probes for six different chromosomes. DESIGN:Semen from 33 normal males and a patient with a translocation was studied using dual color fluorescence in situ hyb...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56896-4

    authors： Lu PY,Hammitt DG,Zinsmeister AR,Dewald GW

    更新日期：1994-08-01 00:00:00

  • Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: a prospective, randomized, double-blind placebo-controlled assay.

    abstract：OBJECTIVE:To determine the effects of low-dose aspirin on ovarian response, uterine and ovarian blood flow velocity, and implantation and pregnancy rates in patients undergoing IVF. DESIGN:Prospective, randomized, double-blind placebo-controlled assay. SETTING:Department of Reproductive Medicine, CER Medical Institut...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(99)00088-6

    authors： Rubinstein M,Marazzi A,Polak de Fried E

    更新日期：1999-05-01 00:00:00

  • Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality.

    abstract：OBJECTIVE:To evaluate whether the developmental potential of the blastocyst is affected by the number of trophectoderm (TE) cells biopsied in preimplantation genetic diagnosis (PGD) cycles. DESIGN:Retrospective study. SETTING:University-affiliated center. PATIENT(S):Women underwent PGD cycles of blastocyst biopsy an...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.01.011

    authors： Zhang S,Luo K,Cheng D,Tan Y,Lu C,He H,Gu Y,Lu G,Gong F,Lin G

    更新日期：2016-05-01 00:00:00

  • Long-term outcome of parenthood project during in vitro fertilization and after discontinuation of unsuccessful in vitro fertilization.

    abstract：OBJECTIVE:To explore the long-term outcome of patients who began IVF treatment by considering not only treatment outcome in the center but also the parenthood project outcome after discontinuation of unsuccessful IVF. DESIGN:Retrospective cohort follow-up study. SETTING:Two French IVF centers. PATIENT(S):Seven hundr...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.05.067

    authors： de La Rochebrochard E,Quelen C,Peikrishvili R,Guibert J,Bouyer J

    更新日期：2009-07-01 00:00:00

  • Selecting cryopreserved semen for assisted reproductive techniques based on the level of sperm nuclear DNA fragmentation resulted in pregnancy.

    abstract：:A cryopreserved sperm sample with a low level of DNA fragmentation was used for intracytoplasmic sperm injection and resulted in a twin birth from a couple with a 10-year history of idiopathic infertility. ...

    journal_title：Fertility and sterility

    pub_type： 信件

    doi：10.1016/j.fertnstert.2003.11.010

    authors： Alvarez JG,Ollero M,Larson-Cook KL,Evenson DP

    更新日期：2004-03-01 00:00:00