A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy.

Abstract:

:Eighteen premenopausal women with symptomatic leiomyomata uteri were enrolled in a stratified, randomized, double-blind, placebo-controlled study evaluating the efficacy of leuprolide acetate (LA) depot treatment before myomectomy. Stratification was based on pretreatment uterine volume (less than 600 cm3 versus greater than or equal to 600 cm3). Nine women received intramuscular (IM) depot LA 3.75 mg every 4 weeks for 12 weeks (group A); nine women received IM placebo with the same injection schedule (group B). All women underwent myomectomy within 4 weeks of their last injection. Mean total intraoperative blood loss was 213 +/- 44 mL (mean +/- standard error of the mean [SEM]) in group A and 302 +/- 43 mL in group B. When data from patients with large uteri (pretreatment uterine volumes of 600 cm3 or greater) were analyzed, mean total blood loss was 189 +/- 44 mL in group A and 390 +/- 20 mL in group B. These data suggest that leuprolide depot treatment before myomectomy may decrease intraoperative blood loss in women with large leiomyomata uteri.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Friedman AJ,Rein MS,Harrison-Atlas D,Garfield JM,Doubilet PM

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

728-33

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)61022-1

journal_volume

52

pub_type

临床试验,杂志文章,随机对照试验
  • Advanced surgical sperm recovery is a viable option for intracytoplasmic sperm injection in patients with obstructive or nonobstructive azoospermia.

    abstract:OBJECTIVE:To determine whether advanced sperm retrieval is appropriate in cases of obstructive and nonobstructive azoospermia. DESIGN:Prospective controlled study. SETTING:Tertiary care center. PATIENT(S):Men with obstructive and nonobstructive azoospermia, and their partners. INTERVENTION(S):Surgical sperm retriev...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(99)00298-8

    authors: Jaroudi K,Coskun S,Hollanders J,Al-Hassan S,Al-Sufayan H,Atared A,Merdad T

    更新日期:1999-09-01 00:00:00

  • Evaluation of progestogen supplementation for luteal phase support in fresh in vitro fertilization cycles.

    abstract:OBJECTIVE:To evaluate the effectiveness of progestogen supplementation in improving clinical pregnancy rates in women undergoing fresh IVF cycles and to compare different routes, start times, durations, and estrogen coadministration regimen. DESIGN:Comprehensive systematic review and meta-analysis. SETTING:University...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.fertnstert.2019.04.021

    authors: Mohammed A,Woad KJ,Mann GE,Craigon J,Raine-Fenning N,Robinson RS

    更新日期:2019-09-01 00:00:00

  • Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome.

    abstract:OBJECTIVE:To determine expression of integrins α₁, α₄, and αVβ₃ in the glandular and luminal epithelium, stroma, and cells in the blood vessel walls of the endometrium from women with recurrent implantation failure (RIF) and to determine if they are of prognostic value in determining pregnancy outcome. DESIGN:Prospect...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.fertnstert.2013.05.007

    authors: Coughlan C,Sinagra M,Ledger W,Li TC,Laird S

    更新日期:2013-09-01 00:00:00

  • Cumuli oophori in tissue culture: hormone production, ultrastructure, and morphometry of early luteinization.

    abstract::The steroidogenic activity of cumulus oophorus granulosa cells obtained from unstimulated rabbits in estrus has been investigated at closely timed intervals in short-term cultures. The presence of viable, structurally well preserved oocytes and the addition of large follicle follicular fluid had no apparent inhibitory...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:

    authors: Nicosia SV,Mikhail G

    更新日期:1975-05-01 00:00:00

  • Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation.

    abstract:OBJECTIVE:Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy ovarian function. DE...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.fertnstert.2007.02.022

    authors: Frydman N,Prisant N,Hesters L,Frydman R,Tachdjian G,Cohen-Bacrie P,Fanchin R

    更新日期:2008-01-01 00:00:00

  • Measurement of the ovarian follicle by ultrasound in ovulation induction.

    abstract::Ultrasonic monitoring of ovarian follicles and estimation of serum estradiol were carried out in 12 patients with clomiphene therapy, in 5 patients with gonadotropin therapy, and in 7 normal controls. The average diameter of preovulatory follicles in normal controls was 12,8 mm; in ovulation induction groups it was 2 ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)44055-0

    authors: Ylöstalo P,Rönnberg L,Jouppila P

    更新日期:1979-06-01 00:00:00

  • Bone density and reproductive hormones in patients with neuroleptic-induced hyperprolactinemia.

    abstract::To study the prevalence of osteoporosis and hyperandrogenism in neuroleptic-induced hyperprolactinemia, the authors evaluated 10 patients. Three were amenorrheic, while seven had oligomenorrhea. Nine patients had galactorrhea. The Ferriman-Gallway hirsutism score was 12 +/- 2. Vaginal smear maturation value was 53 +/-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)60365-5

    authors: Ataya K,Mercado A,Kartaginer J,Abbasi A,Moghissi KS

    更新日期:1988-12-01 00:00:00

  • Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study.

    abstract:OBJECTIVE:To assess whether provision of an educational DVD was more effective in increasing the uptake of elective single embryo transfers (eSET) than an educational brochure in an IVF population. DESIGN:Randomized controlled trial. SETTING:Private IVF clinic. PATIENT(S):One hundred thirty-one couples starting thei...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.fertnstert.2009.03.080

    authors: Hope N,Rombauts L

    更新日期:2010-07-01 00:00:00

  • Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program.

    abstract::This study describes the results with immature human follicular oocytes harvested from unstimulated ovaries, matured in vitro, fertilized, and transferred to an agonadal recipient. Two hundred seventy immature oocytes were aspirated from 23 ovaries removed for various gynecological indications from August 1988 to Octo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)54068-0

    authors: Cha KY,Koo JJ,Ko JJ,Choi DH,Han SY,Yoon TK

    更新日期:1991-01-01 00:00:00

  • Lymphatic spread of endometriosis to pelvic sentinel lymph nodes: a prospective clinical study.

    abstract:OBJECTIVE:To establish the prevalence of endometriosis metastatic to pelvic sentinel lymph nodes (PSLN) in women with ovarian and/or peritoneal endometriosis. DESIGN:Prospective clinical study. SETTING:Academic research institution. PATIENT(S):Women with a laparoscopic diagnosis of ovarian and/or peritoneal endometr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2011.06.070

    authors: Tempfer CB,Wenzl R,Horvat R,Grimm C,Polterauer S,Buerkle B,Reinthaller A,Huber JC

    更新日期:2011-09-01 00:00:00

  • Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.

    abstract::13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was rep...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)39196-8

    authors: Zárate A,Canales ES,Schally AV,Ayala-Valdés L,Kastin AJ

    更新日期:1972-09-01 00:00:00

  • Competitive progesterone antagonists: receptor binding and biologic activity of testosterone and 19-nortestosterone derivatives.

    abstract::Testosterone and 19-nortestosterone derivatives were evaluated in a developmental scheme designed to identify competitive progesterone antagonists having abortifacient activity. Compounds that displayed significant binding to the rabbit uterine progesterone receptor were followed in biologic tests for progestational, ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)44003-3

    authors: Reel JR,Humphrey RR,Shih YH,Windsor BL,Sakowski R,Creger PL,Edgren RA

    更新日期:1979-05-01 00:00:00

  • Endometriosis entrapment of the obturator nerve after previous cervical cancer surgery.

    abstract::A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.03.024

    authors: Langebrekke A,Qvigstad E

    更新日期:2009-02-01 00:00:00

  • Endometrial biopsy during hormone replacement cycle in donor oocyte recipients before in vitro fertilization-embryo transfer.

    abstract:OBJECTIVE:To examine the usefulness of a trial cycle of hormone replacement therapy (HRT) and endometrial biopsy before the actual ET cycle in recipients of donated oocytes. DESIGN:Retrospective review. SETTING:Clinical practice at the South Texas Fertility Center, San Antonio, Texas. PATIENT(S):Thirty-six concurren...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(98)00165-4

    authors: Potter DA,Witz CA,Burns WN,Brzyski RG,Schenken RS

    更新日期:1998-08-01 00:00:00

  • The ReSTAGE Collaboration: defining optimal bleeding criteria for onset of early menopausal transition.

    abstract:OBJECTIVE:Criteria for staging the menopausal transition are not established. This article evaluates five bleeding criteria for defining early transition and provides empirically based guidance regarding optimal criteria. DESIGN/SETTING:Prospective menstrual calendar data from four population-based cohorts: TREMIN, Me...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2007.02.015

    authors: Harlow SD,Mitchell ES,Crawford S,Nan B,Little R,Taffe J,ReSTAGE Collaboration.

    更新日期:2008-01-01 00:00:00

  • Expression of BET genes in testis of men with different spermatogenic impairments.

    abstract:OBJECTIVE:To characterize the BET gene expression in human testis with spermatogenetic impairments; to examine BRDT protein expression in testis and semen. DESIGN:Prospective study. SETTING:Fertility clinic. PATIENT(S):Azoospermic men (n = 120) who underwent testicular sperm extraction and who were classified as eit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2011.10.010

    authors: Barda S,Paz G,Yogev L,Yavetz H,Lehavi O,Hauser R,Botchan A,Breitbart H,Kleiman SE

    更新日期:2012-01-01 00:00:00

  • Microsurgical tubocornual anastomosis for occlusive cornual disease: reproducible results without the need for tubouterine implantation.

    abstract::Microsurgical tubocornual anastomosis (TCA) and tubouterine implantation are the two primary operations used to treat proximal tubal occlusion (PTO). Tubouterine implantation usually has been reserved for cases of PTO in which the occlusion spans the entire intramural tubal segment. Yet TCA has proven to be more likel...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)49630-5

    authors: McComb P

    更新日期:1986-10-01 00:00:00

  • Differing mechanisms of meiotic segregation in spermatozoa from three carriers of a pericentric inversion of chromosome 8.

    abstract:OBJECTIVE:To determine the meiotic segregation of a pericentric inversion of chromosome 8 in three carriers. DESIGN:Analysis of sperm nuclei by fluorescence in situ hybridization (FISH). SETTING:University hospital. PATIENT(S):Three males with an inv(8). INTERVENTION(S):Triple FISH with the 8q and 8p subtelomeres a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2007.04.056

    authors: Caer E,Perrin A,Douet-Guilbert N,Amice V,De Braekeleer M,Morel F

    更新日期:2008-06-01 00:00:00

  • Changes in blood-flow impedance of the human corpus luteum throughout the luteal phase and during early pregnancy.

    abstract:OBJECTIVE:To examine changes in blood flow in the corpus luteum throughout the luteal phase and during early pregnancy. DESIGN:Longitudinal and cross-sectional prospective studies. SETTING:University hospital and city general hospital. PATIENT(S):Sixty-one women with normal menstrual cycles and normal luteal functio...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2007.10.056

    authors: Tamura H,Takasaki A,Taniguchi K,Matsuoka A,Shimamura K,Sugino N

    更新日期:2008-12-01 00:00:00

  • Ovarian response in three consecutive in vitro fertilization cycles.

    abstract:OBJECTIVE:This study was designed to assess the ovarian response in the same patient in consecutive IVF cycles. DESIGN:Retrospective study. SETTING:Assisted reproductive unit at a university hospital. PATIENT(S):One hundred ninety women who underwent three consecutive cycles of IVF. INTERVENTION(S):All women used a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(01)03237-x

    authors: Hoveyda F,Engmann L,Steele J,Lopez Bernal A,Barlow DH

    更新日期:2002-04-01 00:00:00

  • Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment.

    abstract:OBJECTIVE:To determine whether altered follicular environment is associated with ovarian reserve or maternal age. DESIGN:Prospective study examining follicular fluid (FF) composition and follicular cell metabolism. SETTING:University research department and private IVF clinic. PATIENT(S):Women (n = 54) undergoing ro...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2012.06.025

    authors: Pacella L,Zander-Fox DL,Armstrong DT,Lane M

    更新日期:2012-10-01 00:00:00

  • Serum replacement with a growth factor-free synthetic substance in culture medium contributes to effective establishment of mouse embryonic stem cells of various origins.

    abstract:OBJECTIVE:To evaluate whether serum replacement with growth factor-free synthetic substances contributed to the effective establishment of embryonic stem (ES) cells. DESIGN:Randomized, prospective model study. SETTING:Gamete and stem cell biotechnology laboratory at Seoul National University in Korea. ANIMAL(S):F1 (...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.01.056

    authors: Lee ST,Oh SW,Kim DY,Han JY,Moon SY,Lim JM

    更新日期:2006-10-01 00:00:00

  • Abdominal myomectomy for otherwise unexplained infertility.

    abstract::Twenty-three patients with otherwise unexplained infertility underwent abdominal myomectomy for the removal of subserous or intramural myomata. None were submucosal in location. Fifteen of these patients (65.2%) conceived. There were 18 term births in 13 patients. All but 1 patient conceived within the first year. The...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)49536-1

    authors: Rosenfeld DL

    更新日期:1986-08-01 00:00:00

  • Alterations in the organic compounds of vaginal secretions caused by sexual arousal.

    abstract::The low-molecular weight organic constituents of human vaginal secretions from normally cycling subjects were analyzed both before and after sexual stimulation. Gas chromatography and combined gas chromatography-mass spectrometry were employed in the analyses of the secretions. Consistent increases were noted for a nu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:

    authors: Preti G,Huggins GR,Silverberg GD

    更新日期:1979-07-01 00:00:00

  • Genetic evaluation procedures at sperm banks in the United States.

    abstract:OBJECTIVE:To assess how genetic evaluations of sperm donor applicants are performed in the United States. DESIGN:A questionnaire was designed to assess: 1) the professionals involved in the family history evaluation and genetic screening; 2) the genetic testing, counseling, and informed consent processes; and 3) how t...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2013.01.093

    authors: Isley L,Callum P

    更新日期:2013-05-01 00:00:00

  • Screening for subclinical inflammation in ejaculates.

    abstract:OBJECTIVE:To determine the clinical significance of albumin determination in ejaculates by means of an easy office test to screen semen samples for subclinical infection-inflammation. PATIENTS:One hundred fifty-nine randomly chosen males of couples with longstanding infertility (median duration of infertility 4 years ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:

    authors: Eggert-Kruse W,Probst S,Rohr G,Aufenanger J,Runnebaum B

    更新日期:1995-11-01 00:00:00

  • Essure removal: comparison of two minimally invasive approaches.

    abstract:OBJECTIVE:To study differences between robotic and laparoscopic approach in Essure device removal. DESIGN:Demonstration video of two different surgical approaches. SETTING:Clinico San Carlos University Hospital in Madrid, Spain. PATIENT(S):A total of 737 Essure devices were implanted until June 2017 in Clinico San C...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2020.03.025

    authors: Gracia M,Herráez A,Coronado P

    更新日期:2020-07-01 00:00:00

  • Doubling time of urine human chorionic gonadotropin after assisted reproductive technology.

    abstract::In the present study, we measured urinary hCG after assisted reproductive technology to accurately calculate normal doubling time (DT) of hCG, and we compared DT values with prognosis of pregnancy. We clarified the correlation between normal DT values, calculated from urinary hCG levels, and viable and nonviable pregn...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2005.03.066

    authors: Fujiwara H,Motoyama M,Koike T,Ogawa S,Shibahara H,Suzuki M

    更新日期:2005-10-01 00:00:00

  • Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.

    abstract:OBJECTIVE:To evaluate the association between FSH efficacy and FSHR alleles. DESIGN:Retrospective study. SETTING:University-based fertility unit and a private center for biomedical research. PATIENT(S):One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were ca...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(03)00795-7

    authors: de Castro F,Ruiz R,Montoro L,Pérez-Hernández D,Sánchez-Casas Padilla E,Real LM,Ruiz A

    更新日期:2003-09-01 00:00:00

  • Endometriosis may be associated with mitochondrial dysfunction in cumulus cells from subjects undergoing in vitro fertilization-intracytoplasmic sperm injection, as reflected by decreased adenosine triphosphate production.

    abstract:OBJECTIVE:To determine whether endometriosis is associated with mitochondrial dysfunction in cumulus (granulosa [GC]) cells of subjects undergoing IVF-intracytoplasmic sperm injection (ICSI). DESIGN:Prospective cohort study. SETTING:An IVF clinic in a tertiary academic care center. PATIENT(S):Eleven women with endom...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2014.11.002

    authors: Hsu AL,Townsend PM,Oehninger S,Castora FJ

    更新日期:2015-02-01 00:00:00