当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Dual color fluorescence in situ hybridization to investigate aneuploidy in sperm from 33 normal males and a man with a t(2;4;8)(q23;q27;p21)

Dual color fluorescence in situ hybridization to investigate aneuploidy in sperm from 33 normal males and a man with a t(2;4;8)(q23;q27;p21)

Abstract：

OBJECTIVE:To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence in situ hybridization and probes for six different chromosomes. DESIGN:Semen from 33 normal males and a patient with a translocation was studied using dual color fluorescence in situ hybridization with probes for chromosomes 4, 7, 8, 12, 18, X and Y. The frequency of aneuploidy for each chromosome is compared with one another and with the patient who had a t(2;4;8)(q23;q27;p21). SETTING:Specimens were obtained from patients at the Mayo Clinic, Rochester, Minnesota. RESULTS:The percentage of sperm with disomy or nullisomy in normal subjects ranged from 0.2% to 0.6% for each of the chromosomes studied. No statistically significant differences were observed between these chromosomes. The frequency of aneuploidy in sperm from a patient with a t(2;4;8) was 3.3% and 4.8% for chromosomes 4 and 8, respectively. CONCLUSION:Fluorescence in situ hybridization was useful to establish the normal range of nullisomic and disomic sperm for six different chromosomes and to study a patient with a clinically significant chromosome abnormality. In normal males, no difference in the frequency of meiotic nondisjunction was observed among the chromosomes studied.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Lu PY,Hammitt DG,Zinsmeister AR,Dewald GW

doi

10.1016/s0015-0282(16)56896-4

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

394-9

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)56896-4

journal_volume

62

pub_type

杂志文章

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