Evidence for a histaminergic system in the human testis.

Abstract:

:The complete lack of information about mast cells as a source of histamine and potential target cells for histamine in human testes prompted us to investigate these issues in testes of fertile and infertile patients using a combination of laser microdissection, reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemistry. We show for the first time the expression of the rate-limiting enzyme in histamine synthesis-histidine decarboxylase-by human testicular mast cells and the expression of the histamine (H) receptors 1 (H1) and 2 (H2) by germinal, interstitial, and peritubular cells in the testes of fertile and infertile patients.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Albrecht M,Frungieri MB,Gonzalez-Calvar S,Meineke V,Köhn FM,Mayerhofer A

doi

10.1016/j.fertnstert.2004.12.002

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

1060-3

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(04)03189-9

journal_volume

83

pub_type

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