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Potential enhancement of endometrial receptivity in cycles using controlled ovarian hyperstimulation with antiprogestins: a hypothesis.

Abstract：

OBJECTIVE:To manipulate the luteal endometrial progression by the use of antiprogestins. DESIGN:Prospective controlled clinical trial. SETTING:The IVF program of the University of Southern California School of Medicine, Los Angeles, California. PATIENT(S):Thirteen oocyte donors and 20 oocyte recipients. INTERVENTION(S):Controlled ovarian hyperstimulation of oocyte donors, administration of two doses of 2.5 mg of RU486 to the study group, and endometrial biopsies. MAIN OUTCOME MEASURE(S):Serum E2 and P levels, histologic dating of the endometrium, endometrial ultrastructure by scanning electron microscopy. RESULT(S):No difference in serum E2 or P levels was noted after RU486 administration. The histologic dating was advanced in oocyte donors as compared with recipients undergoing artificial cycles but returned to normal (in phase) after RU486. Pinopods were noted in all recipient biopsies and in donors treated with RU486 but in only one of four biopsies in donor controls. CONCLUSION(S):Cycles with controlled ovarian hyperstimulation are associated with high early luteal P levels and advanced endometrial histology. Low doses of RU486 may correct the precocious luteinization and restore endometrial receptivity.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Paulson RJ,Sauer MV,Lobo RA

doi

10.1016/S0015-0282(97)81918-8

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

321-5

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(97)81918-8

journal_volume

67

pub_type

杂志文章

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