Abstract：
OBJECTIVE:To evaluate the efficacy of blastocyst culture and transfer in human in vitro fertilization (IVF) as compared to day 3 embryo transfer. DESIGN:Prospective randomized trial. SETTING:Private assisted reproduction unit. PATIENT(S):A total of 162 IVF patients were included in the day 3 embryo transfer (n = 82) and blastocyst transfer (n = 80) groups. INTERVENTION(S):Embryo transfer on day 3 after culture in the standard culture media and blastocyst transfer on day 5 or 6 after culture in the sequential culture media. MAIN OUTCOME MEASURE(S):Implantation and pregnancy rates, multiple gestation rate. RESULT(S):The implantation rate for embryos transferred at the blastocyst stage was significantly higher than that for embryos transferred on day 3 (26% vs. 13%). The viable pregnancy rate was similar in both groups (29% vs. 26%). Significantly fewer embryos were required for transfer at the blastocyst stage compared with day 3 embryo transfer (2.0 +/- 0.1 vs. 3.5 +/- 0.63). The high-order multiple gestation rate was significantly less with the blastocyst transfer than with the day 3 embryo transfer (4% vs. 19%). CONCLUSION(S):With the use of blastocyst culture, a few embryos can be transferred without decreasing the overall pregnancy rate. This may reduce multiple gestations and improve human IVF outcome.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Karaki RZ,Samarraie SS,Younis NA,Lahloub TM,Ibrahim MHdoi
10.1016/s0015-0282(01)02939-9keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
114-8issue
1eissn
0015-0282issn
1556-5653pii
S0015028201029399journal_volume
77pub_type
临床试验,杂志文章,随机对照试验abstract：:Human testes, removed in treating patients for prostatic carcinoma, were used. Tissues were homogenized and incubated in vitro with labeled progesterone and 2 different antiovulatories, lynestrenol (17alpha-ethin yl-17beta-hydroxy-estr-4-one) and MK 665 (17alpha-chloroethinyl-19-nor-4 ,9(10)-androstadiene-17beta-ol-...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)36309-9
更新日期：1967-05-01 00:00:00
abstract：OBJECTIVE:To examine the influence of hormone-related factors on the risk of invasive epithelial ovarian cancer (ovarian cancer). DESIGN:Population-based case-control study using in-person interviews. SETTING:Academic department of preventive medicine. PATIENT(S):Four hundred seventy-seven ovarian cancer patients an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.03.013
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To elucidate the role of vitamin D in reproduction by examining the relationship between recipient vitamin D levels and pregnancy rates in donor-recipient IVF cycles. DESIGN:Retrospective cohort study. SETTING:Academic tertiary care center. PATIENT(S):Ninety-nine recipients of egg donation at University of...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.10.008
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To compare the main outcome of IUI with the Gynetics catheter (Gynetics Medical Products, Hamont-Achel, Belgium) or the Makler cannula (Sefi-Medical Instruments, Haifa, Israel). DESIGN:Prospective, randomized study. SETTING:Infertility and endocrinology unit in a university hospital. PATIENT(S):Two hundred...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2004.08.034
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To determine whether patients support a mandatory single blastocyst transfer (mSBT) policy in IVF. DESIGN:Prospective survey study. SETTING:Academic hospital-based infertility center. PATIENT(S):Two hundred sixty-two female patients presenting for fresh or cryopreserved/thawed ET after IVF. INTERVENTION(S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.07.1140
更新日期：2011-10-01 00:00:00
abstract：:Four individuals with a complaint of infertility were evaluated after a semen analysis had demonstrated no motility. The semen analyses were otherwise normal, with the exception of a low count in one subject. All had normal percentages of living sperm. One of the individuals had chronic respiratory disease, and two ot...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47549-7
更新日期：1984-01-01 00:00:00
abstract：:The immediate and long term fertility after bilateral ovarian wedge resection in 53 women with clomiphene citrate-resistant hyperandrogenic chronic anovulation is related to the histology of the ovarian wedges. Patients with polycystic ovaries and hyperplastic stromal abnormalities had most spontaneous conceptions and...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60845-2
更新日期：1989-08-01 00:00:00
abstract：:Follow-up of 54 patients undergoing modified single-layer bilateral vasovasostomies are presented with attention to semen quality, pregnancy rates, and postoperative findings potentially inhibiting fertility. The technical success rate was 98%, but 3-month semen analyses varied from "poor" (less than 20(6)/ml; greater...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47789-7
更新日期：1984-04-01 00:00:00
abstract：OBJECTIVE:To compare the pregnancy outcomes of twin pregnancies following early transvaginal multifetal pregnancy reduction (MPR) with nonreduced twin gestations. DESIGN:Prospective cohort study. SETTING:Two tertiary medical centers. PATIENT(S):A cohort of 77 multiple pregnancies after reduction to twins and 78 dich...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2014.01.032
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To develop molecular tools increasing the sensitivity of breast cancer micrometastases detection within ovarian tissue cryopreserved for fertility preservation. DESIGN:Expression of breast markers was evaluated by quantitative polymerase chain reaction in ovarian tissue from patients with benign or cancerous...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.04.036
更新日期：2015-08-01 00:00:00
abstract：:The penetration of a gonadotropin-releasing hormone agonist (GnRH-a), Buserelin (Hoechst AG, Frankfurt, West Germany), into human follicular fluids (FF) was studied by means of a radioimmunoassay (RIA) and a bioassay. Acute nasal administration of a therapeutic dose of Buserelin (300 and 600 micrograms) before the ovu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60852-x
更新日期：1989-08-01 00:00:00
abstract：OBJECTIVE:To explore the effectiveness of percutaneous vasal sperm aspiration (PVSA) in combination with intrauterine insemination (IUI) to treat infertile men with anejaculation. DESIGN:Clinical study. SETTING:Department of reproductive endocrinology and andrology of a family planning research clinic. PATIENT(S):Tw...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04697-6
更新日期：2003-03-01 00:00:00
abstract：:The serial measurement of serum hCG concentrations is an important clinical tool used to differentiate normal from abnormal pregnancies. At hCG values below which ultrasonography can be diagnostic, the comparison of a patient's hCG dynamics to those of established expected curves of rise or fall can aid the clinician ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2012.09.014
更新日期：2012-11-01 00:00:00
abstract：:A human embryo consisting of two cells, each containing two pronuclei, was found in the IVF laboratory. The most likely explanation for this phenomenon is a parthenogenetic activation of an oocyte leading to immediate cleavage and followed by double fertilization. Human chimerism may originate in this way. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53780-7
更新日期：1990-09-01 00:00:00
abstract：OBJECTIVE:To investigate the role of mutations or polymorphisms in the NPY-Y1R gene in human idiopathic central pubertal disorders. DESIGN:Molecular studies. SETTING:University hospital. PATIENT(S):Thirty-three patients with gonadotropin-dependent precocious puberty, 22 with hypogonadotropic hypogonadism, and 50 con...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.07.1519
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:To determine whether the known inactivating FSH receptor gene mutations are present in Japanese women with secondary amenorrhea because of premature ovarian failure (POF) and polycystic ovary syndrome (PCOS). DESIGN:Clinical and molecular studies. SETTING:An outpatient clinic in a university hospital. PATI...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(00)01673-3
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To compare obstetric and perinatal outcomes of singleton pregnancies resulting from embryos incubated in a time-lapse system (TLS) with those of embryos grown in standard IVF incubators (SI). DESIGN:Retrospective description of a cohort of patients who conceived during a randomized, controlled trial. SETTIN...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2017.06.031
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether microfluidic sperm sorters (MFSSs) allow effective recovery of sorted motile sperm without DNA damage compared with the centrifugation and swim-up procedure. DESIGN:Experimental laboratory study. All participants completed questionnaires regarding previous and/or current diseases, surgery...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.10.023
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To develop and validate a specific simple measure of insulin sensitivity using oral glucose tolerance test (OGTT) values for lean polycystic ovary syndrome (PCOS) women. DESIGN:Retrospective study. SETTING:Gynecologic Outpatient Clinic of University Hospital, affiliated with Unit of Gynecologic Endocrinolog...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.04.004
更新日期：2014-07-01 00:00:00
abstract：:This study describes maternal and birth outcomes of primiparae aged ≥ 45. High rates of pregnancy complications and poor birth outcomes were found, stressing that the personal risks and ramifications to the health system should be taken into account in establishing obstetric health policy regarding primiparity at adva...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.02.031
更新日期：2011-06-30 00:00:00
abstract：:This study investigated the prevalence of Tyr204Phe and Val34Leu polymorphisms in two Brazilian ethnic groups (171 Caucasians and 27 Blacks, and 117 men and 81 women) and in patients with recurrent miscarriages (RM) (86 women: 53 Caucasians and 33 Blacks). Study groups were matched to control groups by race and age. T...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.04.052
更新日期：2004-11-01 00:00:00
abstract：:Surrogacy raises a number of concerns about the psychological adjustment of the surrogate, the parents, and the child. Despite surrogacy becoming more common, research into the postdelivery psychological adjustment of the individuals involved has lagged far behind. This review examines research on the psychological ad...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2020.03.010
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To describe a novel mutation in the fumarate hydratase (FH) gene in a family with atypical uterine leiomyomas. DESIGN:Case report and review of the literature. SETTING:Academic community hospital. PATIENT(S):Three sisters who presented as nulligravidas aged 27-30 years with large atypical uterine leiomyoma...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.09.034
更新日期：2016-01-01 00:00:00
abstract：:Luteinization of an unruptured ovarian follicle has been reported as a cause of infertility and has heretofore been diagnosed only by direct visualization of the ovarian surface. Four patients who demonstrated defects in ovulation requiring therapy to induce ovulation and who were not achieving desired conception desp...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46160-1
更新日期：1982-04-01 00:00:00
abstract：:In summary, the luteal phase defect is a deficiency of corpus luteum progesterone steroidogenesis, either in amount or duration, or both. The clinical manifestations include either primary infertility or repeated first trimester abortions. The diagnosis can only be made clinically on the basis of a well-timed endometr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41769-3
更新日期：1976-04-01 00:00:00
abstract：:The complete lack of information about mast cells as a source of histamine and potential target cells for histamine in human testes prompted us to investigate these issues in testes of fertile and infertile patients using a combination of laser microdissection, reverse transcription-polymerase chain reaction (RT-PCR),...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.12.002
更新日期：2005-04-01 00:00:00
abstract：:The thing that hath been, it is that which shall be; and that which is done is that which shall be done: and there is no new thing under the sun. -Ecclesiastes 1:9, King James Bible. ...
journal_title：Fertility and sterility
pub_type： 社论
doi：10.1016/j.fertnstert.2018.02.114
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer. DESIGN:Retrospective study. SETTING:McGill Reproductive Center, Montreal, Canada. PATIENT(S):Women with endometrial thickness <6 mm on days 6-10 ultrasound (US) scan of ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.07.1750
更新日期：2009-09-01 00:00:00
abstract：:Although salpingitis frequently produces tubal damage and infertility, many women with tubal factor as a cause of their infertility do not have a clinical history of salpingitis. In order to investigate whether or not some such cases might be due to subclinical chlamydial infections, we measured antichlamydial antibod...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46634-3
更新日期：1982-11-01 00:00:00
abstract：:Combined therapy with clomiphene and intranasal luteinizing hormone-releasing hormone (LHRH) was used to induce ovulation in eight chronically anovulatory patients under treatment for infertility. Clomiphene, 100 mg daily, was given from the 5th to the 9th day of the cycle. Synthetic LHRH was administered intranasally...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
