Abstract:
:The penetration of a gonadotropin-releasing hormone agonist (GnRH-a), Buserelin (Hoechst AG, Frankfurt, West Germany), into human follicular fluids (FF) was studied by means of a radioimmunoassay (RIA) and a bioassay. Acute nasal administration of a therapeutic dose of Buserelin (300 and 600 micrograms) before the ovum pickup for in vitro fertilization leads to significant concentrations of Buserelin in one-third of the FF. These concentrations ranged between 28 and 124 pg/ml, which represents 10% to 50% of the serum concentrations achieved in these patients. Follicular penetration of this agonist is time-dependent. Chronic administration during the follicular phase leads to low but significant concentrations of peptide 36 hours after the last inhalation. A very good correlation was observed between the RIA and the bioassay. This demonstrates the accuracy and the specificity of the RIA. In addition, it indicates that the Buserelin that reaches follicles is intact and is not the inactive product of degradation. Intranasal administration of Buserelin stopped 35 hours before ovum pickup appears to be an adequate way of minimizing the exposure of maturing oocytes to the GnRH-a.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Loumaye E,Coen G,Pampfer S,Vankrieken L,Thomas Kdoi
10.1016/s0015-0282(16)60852-xsubject
Has Abstractpub_date
1989-08-01 00:00:00pages
256-63issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(16)60852-Xjournal_volume
52pub_type
杂志文章abstract:OBJECTIVE:To identify factors influencing the development of endometrial autografts in a monkey model of endometriosis. DESIGN:Prospective, comparative study. SETTING:Animal research unit. SUBJECTS:Thirty regularly cycling cynomolgus monkeys in three groups of 10 each. INTERVENTIONS:Endometrium was minced and spill...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58521-5
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of deep endometriosis (DE) on bladder function, focusing on detrusor pattern, in patients without preoperative urinary symptoms. DESIGN:Prospective study. SETTING:Academic research center. PATIENT(S):A total of 25 asymptomatic patients: 12 patients with DE (group 1) and 13 patients w...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.06.044
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To investigate the long-term effects of raloxifene on fasting plasma homocysteine levels in postmenopausal women compared with conjugated equine estrogen (CEE). DESIGN:Randomized, double-blind, placebo-controlled study. SETTING:Outpatient department of a university hospital. PATIENT(S):Fifty-two hysterecto...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(98)00381-1
更新日期:1998-12-01 00:00:00
abstract::The antiprogesterone compound RU 486 (17 beta-hydroxy-11 beta-[4-dimethylaminophenyl]-17 alpha-[ 1-propynyl]estra-4,9-dien-3-one; Roussel-Uclaf, Paris, France) was used to induce menstruation in a randomized controlled trial. Castrated adult female cynomolgus monkeys (n = 17) received sequential subcutaneous Silastic ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47246-8
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:To assess the impact of embryo retention in the embryo transfer catheter followed by "immediate" retransfer on pregnancy outcome in women undergoing assisted reproduction. DESIGN:Retrospective analysis of embryo transfer following in vitro fertilization. SETTING:Assisted reproductive technology practice in ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.01.035
更新日期:2004-08-01 00:00:00
abstract::Combined therapy with clomiphene and intranasal luteinizing hormone-releasing hormone (LHRH) was used to induce ovulation in eight chronically anovulatory patients under treatment for infertility. Clomiphene, 100 mg daily, was given from the 5th to the 9th day of the cycle. Synthetic LHRH was administered intranasally...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the results of IVF in women > or = 40 years of age using their own oocytes. DESIGN:Retrospective study. SETTING:Wolfson and Royal Masonic in vitro fertilization units, London, United Kingdom. PATIENT(S):A total of 1,087 IVF cycles were started in women > or = 40 years of age. INTERVENTION(S):M...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00353-7
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of resveratrol on growth and function of granulosa cells. Previously, we demonstrated that resveratrol exerts profound proapoptotic effects on theca-interstitial cells. DESIGN:In vitro study. SETTING:Research laboratory. ANIMAL(S):Immature Sprague-Dawley female rats. INTERVENTION(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.004
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To investigate the association between several factors such as demographics, personal habits, reproductive factors, menstrual characteristics, contraception, and clinical profile and the probability of having endometriosis. SETTING:Ten clinical institutions in the Montreal area. PATIENT(S):A total of 2777 s...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.10.038
更新日期:2004-06-01 00:00:00
abstract::A total of 82 patients underwent 106 cycles in which immature oocytes were recovered after hCG priming and transferred at blastocyst-stage. After transfer, the implantation rate was 26.8%, and the clinical pregnancy rate was 51.9%. We found that the oocytes retrieved after hCG priming in women with high risk of ovaria...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.11.027
更新日期:2007-06-01 00:00:00
abstract::Earlier studies have shown inherited thrombophilia to be a risk factor for recurrent implantation failure, raising the question of whether this risk is related to the underlying cause of unexplained infertility or to the mechanisms involved in the implantation process. When nine thrombophilic gene polymorphisms were c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1782
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of compound genetic abnormalities in patients who are carriers of cystic fibrosis mutations. DESIGN:Case report. SETTING:Tertiary referral center for male infertility. PATIENT(S):Between 2000 and 2005, 65 patients were identified to be carriers of cystic fibrosis transmembrane r...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.07.1537
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To report a dichorionic quadramniotic quadruple gestation with monochorionic triamniotic triplets after intracytoplasmic sperm injection (ICSI) treatment and transfer of two embryos. DESIGN:Case report. SETTING:Academic reproductive medicine center. PATIENT(S):A 28-year-old nulligravida who underwent first...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.08.022
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To determine the expression of nitric oxide synthases (NOSs) and their modulation by hypoxia in human peritoneal (NF) and adhesion fibroblasts (ADF). DESIGN:Prospective experimental study. SETTING:University medical center. PATIENT(S):Fibroblasts from peritoneum and adhesion tissues. INTERVENTION(S):Hypox...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.07.1313
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To determine whether inhibition of epidermal growth factor (EGF) receptor tyrosine kinase with lapatinib affects oocyte maturation, expression of the cumulus expansion-associated genes such as tumor necrosis factor alpha-induced protein 6 (TNFAIP6) and prostaglandin-endoperoxide synthase 2 (PTGS2), and synthe...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.12.040
更新日期:2013-05-01 00:00:00
abstract::Turner syndrome results in infertility in most cases. Fertility preservation through the cryopreservation of oocytes or ovarian tissue may be an option for some girls with Turner syndrome. Oocyte donation results in high pregnancy rates (PR). Those women who plan to pursue pregnancy need comprehensive screening and co...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2012.08.022
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy. DESIGN:Review of English publications in PubMed and Embase to April 6, 2020. METHOD(S):Articles were screened for reports including coronavirus, r...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.04.025
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To assess the possibility of reducing the risk of unwanted pregnancy through a controlled intervention program that was based on a sex education workshop. DESIGN:Educational intervention study. SETTING:Newly drafted women in a central absorption army base in Israel. PATIENT(S):One thousand seven hundred ni...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00252-5
更新日期:1997-09-01 00:00:00
abstract::Two women with the polycystic ovary syndrome were treated with bromocriptine (15 to 20 mg/day) in combination with spironolactone (100 mg/day). In the first woman the combined therapy induced a marked reduction of hirsutism, with ensuing ovulation and pregnancy. In the second woman, who had hyperthecosis and had been ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45554-8
更新日期:1981-06-01 00:00:00
abstract::The rapid postpartum return of gonadotropic function during bromocriptine treatment was investigated through hormonal measurements in 15 women. Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG). Prolactin was effectively suppressed by ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60610-6
更新日期:1989-04-01 00:00:00
abstract::Despite the introduction of new ovulation-inducing agents, CC remains the drug of choice for most anovulatory patients. Before initiating therapy, patients should be evaluated to determine the cause of anovulation. Patients with ovarian failure, hyperprolactinemia, hypothyroidism, or forms of CAH should be treated wit...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)48129-x
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:To measure autoantibodies that recognize oxidatively modified proteins in the sera of women with surgically proven endometriosis. DESIGN:Prospective study. SETTING:Tertiary care academic medical center. PATIENT(S):Women undergoing surgery for endometriosis or tubal ligation. INTERVENTION(S):None. MAIN OU...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00145-4
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples. DESIGN:Prospective cohort study. SE...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.06.071
更新日期:2005-02-01 00:00:00
abstract::Human spermatozoa were separated according to their motility by centrifuging semen on discontinuous Percoll gradients. Fractions of the gradients were examined for sperm motility, velocity, viability, morphology, bacteria, and sperm function using the hamster ova sperm penetration assay. The percentage of motile sperm...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47426-1
更新日期:1983-11-01 00:00:00
abstract::To study the prevalence of osteoporosis and hyperandrogenism in neuroleptic-induced hyperprolactinemia, the authors evaluated 10 patients. Three were amenorrheic, while seven had oligomenorrhea. Nine patients had galactorrhea. The Ferriman-Gallway hirsutism score was 12 +/- 2. Vaginal smear maturation value was 53 +/-...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60365-5
更新日期:1988-12-01 00:00:00
abstract::Four individuals with a complaint of infertility were evaluated after a semen analysis had demonstrated no motility. The semen analyses were otherwise normal, with the exception of a low count in one subject. All had normal percentages of living sperm. One of the individuals had chronic respiratory disease, and two ot...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47549-7
更新日期:1984-01-01 00:00:00
abstract::Forty-one subjects with hyperprolactinemia underwent testing on separate occasions with nomifensine, an indirectly acting dopamine agonist, and domperidone, a dopamine receptor-blocking agent. Nomifensine (200 mg orally) did not significantly modify plasma levels of prolactin (PRL) in 17 subjects in whom the existence...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45314-8
更新日期:1981-02-01 00:00:00
abstract::"To understand the actual world as it is, not as we should wish it to be, is the beginning of wisdom." - Bertrand Russell. ...
journal_title:Fertility and sterility
pub_type: 社论
doi:10.1016/j.fertnstert.2018.06.007
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To medically and psychologically assess gay men seeking parenthood through assisted reproduction and to provide guidelines for the assessment. DESIGN:Qualitative observational study. SETTING:Academic medical center. PATIENT(S):Thirty gay males (15 couples) presenting for assisted reproduction using an oocy...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.05.053
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To examine sperm motility, total antioxidant level (TAC), DNA fragmentation, and medical history in infertile men with high seminal high reactive oxygen species (ROS). DESIGN:Prospective study. SETTING(S):Tertiary care hospital. PATIENT(S):Infertile men (n=101). INTERVENTION(S):Group I (n=57) included men...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.12.030
更新日期:2010-11-01 00:00:00