Abstract：
:Despite the introduction of new ovulation-inducing agents, CC remains the drug of choice for most anovulatory patients. Before initiating therapy, patients should be evaluated to determine the cause of anovulation. Patients with ovarian failure, hyperprolactinemia, hypothyroidism, or forms of CAH should be treated with the appropriate replacement therapy. Evaluation of male factor and tubal patency should be obtained. Once CC therapy is initiated, careful monitoring should be continued. Confirmation of ovulation by endometrial biopsy or serum P levels is essential. CC doses should be increased monthly until normal luteal function is demonstrated. If the patient does not conceive in three ovulatory cycles, her treatment should be further evaluated by postcoital testing, repeat serum P measurement, and review of her endocrine findings. Patients with poor cervical mucus may benefit from midcycle estrogen. Patients with elevated T may benefit from prednisone suppressive therapy. Patients with abnormal HSGs should have laparoscopy and surgical correction if feasible. After six ovulatory cycles without conception, all patients should undergo laparoscopy. If laparoscopy is normal, therapy can be continued for a total of 10 to 12 cycles. Patients with reduced fecundability (male factor, minimal endometriosis, or minimal tubal adhesions) may require a longer time to conceive.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Hammond MGdoi
10.1016/s0015-0282(16)48129-xsubject
Has Abstractpub_date
1984-10-01 00:00:00pages
499-509issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(16)48129-Xjournal_volume
42pub_type
杂志文章,评审abstract：:Epidermal growth factor/urogastrone (EGF/URO) was measured in the seminal plasma of 214 untreated patients attending an infertility clinic. Patients were assigned groups according to sperm density and progressive motility and in the case of azoospermia into an obstructive etiology or germinal failure. There was no sig...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60198-x
更新日期：1988-10-01 00:00:00
abstract：OBJECTIVE:To study and evaluate a sequential, extended embryo culture system. DESIGN:Prospective study. SETTING:University-affiliated IVF clinic. PATIENT(S):All couples who were treated between October 1997 and July 1998. INTERVENTION(S):A standard human tubal fluid plus 10% serum substitute supplement (SSS) cultur...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00294-0
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether DNA fragmentation and/or mitochondrial membrane potential (MMP) predict natural conception better than standard sperm parameters. DESIGN:Prospective cross-sectional study. SETTING:University medical center. PATIENT(S):Eighty-five infertile and 51 fertile men. INTERVENTION(S):Assessment...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.11.037
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:To assess the discriminative capacity of Chlamydia antibody titers in the diagnosis of tubed pathology in subfertile patients. DESIGN:Meta-analysis of studies comparing Chlamydia antibody titers and laparoscopy for tubal patency and peritubal adhesions. PATIENTS:A total of 2,729 patients with subfertility i...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析
doi：10.1016/s0015-0282(97)81435-5
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:To compare saline infusion sonography (SIS) with gel instillation sonography (GIS) in terms of feasibility and diagnostic accuracy. DESIGN:Prospective cohort study. SETTING:Leuven University bleeding clinic. PATIENT(S):A total of 804 patients: two consecutive cohorts of 402 women undergoing SIS or GIS. IN...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2010.04.074
更新日期：2011-01-01 00:00:00
abstract：:Seminiferous tubules from rats killed 24 hours after injection of pargyline, a monoamine oxidase inhibitor, did not grow well in tissue culture when compared to control tubules. Treated tubules showed severe tubular degeneration and loss of cellular detail after nine days in culture. Animals injected with pargyline fo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)40992-1
更新日期：1975-03-01 00:00:00
abstract：:Plasma preptin levels were higher in women with PCOS compared with the control group (mean±SD, 823.2±140.7 vs. 324.9±147.3 pg/mL). This article suggests a potential role of preptin in the pathogenesis of PCOS. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.08.058
更新日期：2011-01-01 00:00:00
abstract：:To protect the patient from getting misleading information, these guidelines have been revised to reflect more stringent requirements for advertising and marketing. ...
journal_title：Fertility and sterility
pub_type： 指南,杂志文章
doi：10.1016/j.fertnstert.2004.07.936
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To report our experience with genetic screening of oocyte donor candidates and to determine the frequency with which significant genetic issues are identified. DESIGN:Prospective genetic screening of oocyte donor candidates. SETTING:University hospital oocyte donation program. PATIENT(S):Women presenting c...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(98)00109-5
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:To analyze the data available on the biologic significance of white blood cells (WBC) in semen of infertility patients. DATA RESOURCES:The relevant literature was reviewed. RESULTS:It is not possible to identify reliably WBC by conventional sperm staining techniques. The peroxidase method is sufficient for ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)57588-8
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVE:The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. ...
journal_title：Fertility and sterility
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.fertnstert.2012.01.128
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To identify whether the cause, site of ductal obstruction, and characteristics of fluid aspirates are associated with the cryosurvival and fertility after thawing of sperm obtained during reconstruction of the excurrent ducts with microsurgical epididymal sperm aspiration, vasal sperm aspiration, or both. DE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00274-4
更新日期：1997-10-01 00:00:00
abstract：:The association of insulin resistance, hyperandrogenism, and acanthosis nigricans is well established. The ovary is thought to be the site of the excess androgen production. The purpose of this study was to assess the adrenal contribution to the hyperandrogenic state in these women. Twenty-three patients presenting wi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)50001-6
更新日期：1987-02-01 00:00:00
abstract：OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2009.02.055
更新日期：2010-06-01 00:00:00
abstract：:This population-based study assessed information needs related to fertility and sexual function in 250 non-Hodgkin's lymphoma survivors from a Los Angeles Surveillance, Epidemiology, and End Results cancer registry 2-5 years after diagnosis. Results suggest that many survivors have persistent fertility and sexual conc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.08.081
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:The purpose of the study was to describe and to compare the rate of rise of human chorionic gonadotropin (hCG) in vanishing twin and normally progressing twin pregnancies during the first trimester. DESIGN:All patients with twin pregnancies between 1985 and 1989 were prospectively studied. Human chorionic go...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54475-6
更新日期：1991-08-01 00:00:00
abstract：:Repetitively short luteal phases were found in eight infertile women. The short luteal phase was defined as 10 days or less from the presumed time of ovulation (as assessed by basal body temperature recording) to the onset of menses. Clomiphene citrate (Clomid) therapy resulted in pregnancy in two patients and lengthe...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)43930-0
更新日期：1979-04-01 00:00:00
abstract：OBJECTIVE:This report describes an unusual case in which a naturally conceived pregnancy is associated with spontaneous ovarian hyperstimulation and hypothyroidism. DESIGN:Case report. SETTING:University medical center. PATIENT(S):A 30-year-old pregnant woman with abdominal pain and distension caused by ovarian hype...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.003
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:To investigate the expression pattern of proinflammatory, anti-inflammatory, and angiogenic cytokines and their effect on various mediators of endometrial receptivity in women with idiopathic recurrent spontaneous miscarriage (IRSM). DESIGN:A prospective study. SETTING:Tertiary care hospital and reproductiv...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.08.034
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To determine the role of heterozygosity for mutations in the 21-hydroxylase gene (CYP21) in the pathogenesis of hyperandrogenism. DESIGN:Controlled clinical study. SETTING:Tertiary care institutional hospital. PATIENT(S):Forty hirsute women and 13 healthy control women. INTERVENTION(S):The source of andro...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(99)00317-9
更新日期：1999-10-01 00:00:00
abstract：:This prospective study evaluated the efficacy of transvaginal ultrasonography combined with water-contrast in the rectum (RWC-TVS) in the diagnosis of rectal infiltration in 35 women with rectovaginal endometriosis; ultrasonographic findings were compared with surgery and histology. The sensitivity of RWC-TVS in ident...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1336
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To establish a nonhuman primate model addressing follicular development in cryopreserved prepubertal ovarian tissue after xenografting. DESIGN:Experimental study. SETTING:Academic research center. ANIMAL(S):Ovarian tissue from female prepubertal common marmoset (Callytrix jacchus jacchus) grafted into immu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.11.003
更新日期：2011-03-15 00:00:00
abstract：:Suppressor activity in in vitro fertilization (IVF) culture medium correlates with successful implantation. High performance liquid chromatography fractionation revealed peak(s) of inhibitory activity in the 1,000- to 5,000-Da molecular weight range. Inhibitory activity was dependent on the presence of fetal bovine se...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVE:To investigate a new role of interleukin (IL)-17A in endometriosis. DESIGN:Laboratory study. SETTING:University hospital. PATIENT(S):Patients with ovarian endometrioma undergoing laparoscopy or laparotomy. INTERVENTION(S):Primary culture of endometrioma stromal cells (EoSCs) was stimulated with IL-17A. Se...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.07.1117
更新日期：2012-11-01 00:00:00
abstract：:During an 18-month period 219 couples and 3 single women were counseled concerning private, non-agency adoption. Ninety-seven clients adopted privately a total of 105 babies. Thirty-one other couples are still actively pursuing adoption, 39 are no longer pursuing adoption, 13 became pregnant, 9 adopted through an agen...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46164-9
更新日期：1982-04-01 00:00:00
abstract：OBJECTIVE:To investigate alterations in the overall gene expression profile of endometriosis-derived stroma with increasing concentrations of hCG by using the Affymetrix GeneChip U133 Set. DESIGN:In vitro study. SETTING:Academic research institution. PATIENT(S):Women undergoing diagnostic laparoscopic surgery for en...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.02.006
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of metformin in polycystic ovary syndrome (PCOS). As follow-up on a previous paper describing hormonal and metabolic factors, this paper focuses on correlations between adiponectin and anthropometric, hormonal, and metabolic factors in PCOS and the effect of metformin. DESIGN:Randomize...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2010.01.057
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. DESIGN:Retrospective analysis. SETTING:Not applicable. PATIENT(S):5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ul...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.10.004
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To identify early ultrasound markers in pregnant patients that predict a favorable pregnancy outcome. DESIGN:Retrospective case-control study. SETTING:Infertility patients in fertility clinic. PATIENT(S):1051 women with early pregnancies conceived after fertility treatment. INTERVENTION(S):None. MAIN OUT...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.08.009
更新日期：2011-11-01 00:00:00
abstract：:The high rates of unplanned pregnancy reflect an unmet need for effective contraceptive methods for women, especially for individuals with health risks such as obesity, diabetes, hypertension, and other conditions that may contraindicate use of an estrogen-containing product. Improvements in safety, user convenience, ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2016.07.1115
更新日期：2016-11-01 00:00:00
