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Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging.

Abstract：

OBJECTIVE:The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. METHOD(S):Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. RESULT(S):STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics. CONCLUSION(S):STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Harlow SD,Gass M,Hall JE,Lobo R,Maki P,Rebar RW,Sherman S,Sluss PM,de Villiers TJ,STRAW + 10 Collaborative Group.

doi

10.1016/j.fertnstert.2012.01.128

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

843-51

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)00187-2

journal_volume

97

pub_type

共识发展会议,杂志文章,实务指引

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