Higher chromosomal aberration rate in miscarried conceptus from polycystic ovary syndrome women undergoing assisted reproductive treatment.

Abstract:

OBJECTIVE:To assess the potential association between polycystic ovary syndrome (PCOS) and chromosomally aberrant miscarriage during treatment with assisted reproductive technology (ART). DESIGN:A retrospective, single-center study. SETTING:University-affiliated reproductive center. PATIENT(S):A total of 328 patients sent their first trimester miscarried chorionic villus for genetic examination after ART in our center from January 2013 to September 2016, of which 119 cases were women with PCOS and 209 were non-PCOS controls. No known definite miscarriage-related concomitants existed in any study subject. INTERVENTION(S):Single nucleotide polymorphism array analysis was performed on all collected samples. MAIN OUTCOME MEASURE(S):Frequency of aberrant karyotype of miscarried conceptus and the correlation between PCOS and chromosomally aberrant miscarriage. RESULT(S):A total of 173 (52.7% of 328) conceptuses were identified as chromosomally aberrant by single nucleotide polymorphism array. Chromosomal aberrations were more frequent in conceptuses from PCOS patients compared with controls (61.3% vs. 47.8%). Furthermore, both univariate and multivariable analysis identified PCOS as a risk factor for an embryo/fetus to be chromosomally abnormal, with odds ratios of 1.957 (95% confidence interval, 1.067-3.590) and 2.008 (95% confidence interval, 1.038-3.883), respectively. CONCLUSION(S):Women with PCOS were at an increased risk of miscarrying a chromosomally aberrant embryo/fetus compared with non-PCOS controls during ART. Mechanisms require further investigation. Preimplantation genetic screening might be an effective approach to decrease the risk of spontaneous miscarriage for women with PCOS.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Li Y,Wang L,Xu J,Niu W,Shi H,Hu L,Zhang Y,Zhang M,Bao X,Zhang N,Sun Y

doi

10.1016/j.fertnstert.2019.01.026

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

936-943.e2

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(19)30064-0

journal_volume

111

pub_type

杂志文章
  • Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and increased expression of CD44 splice variants.

    abstract:OBJECTIVE:We previously demonstrated that adherence of endometrial epithelial (EECs) and stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) is partly regulated by ESC/EEC CD44 interactions with PMC associated hyaluronan. CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice va...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.12.012

    authors: Griffith JS,Liu YG,Tekmal RR,Binkley PA,Holden AE,Schenken RS

    更新日期:2010-04-01 00:00:00

  • Posthumous assisted reproduction: a survey of attitudes of couples seeking fertility treatment and the degree of agreement between intimate partners.

    abstract:OBJECTIVE:To study attitudes about posthumous assisted reproduction (PAR) in individuals presenting for assisted reproduction, to examine the degree of concordance of attitudes within couples, and to determine whether individuals can accurately predict the attitudes of their intimate partners. DESIGN:Cross sectional s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2011.09.018

    authors: Nakhuda GS,Wang JG,Sauer MV

    更新日期:2011-12-01 00:00:00

  • Retinoic acid suppresses interleukin-6 production in human endometrial cells.

    abstract:OBJECTIVE:To determine whether retinoic acid (RA) can regulate the expression of interleukin (IL)-6 in human endometrial cells in a manner that might be beneficial to women with endometriosis. DESIGN:In vitro study. SETTING:Academic medical center. PATIENT(S):Patients with endometriosis and controls. INTERVENTION(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(00)00483-0

    authors: Sawatsri S,Desai N,Rock JA,Sidell N

    更新日期:2000-05-01 00:00:00

  • Expression of vascular endothelial growth factor messenger ribonucleic acid and protein in human preimplantation embryos.

    abstract::In contrast to a previous report by Krussel et al., with the inclusion of larger numbers of unfertilized oocytes and normal embryos and more sensitive immunofluorescence, this study shows that expression of vascular endothelial growth factor messenger ribonucleic acid can be detected from the oocyte to the blastocyst ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2005.11.047

    authors: Hwu YM,Chen CP,Li SH,Chen PW,Lee RK,Fleming S

    更新日期:2006-06-01 00:00:00

  • Uterus transplantation: animal research and human possibilities.

    abstract::Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2012.04.001

    authors: Brännström M,Diaz-Garcia C,Hanafy A,Olausson M,Tzakis A

    更新日期:2012-06-01 00:00:00

  • Spermatogonial proliferation patterns in men with azoospermia of different etiologies.

    abstract:OBJECTIVE:To demonstrate the pattern(s) of spermatogonial proliferation in different spermatogenic disorders. DESIGN:Retrospective case-control study. Teaching hospital. PATIENT(S):Azoospermic men who underwent testicular biopsy for sperm recovery and preparation for intracytoplasmic sperm injection. INTERVENTION(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(03)02161-7

    authors: Bar-Shira Maymon B,Yogev L,Yavetz H,Lifschitz-Mercer B,Schreiber L,Kleiman SE,Botchan A,Hauser R,Paz G

    更新日期:2003-11-01 00:00:00

  • Infertility among women working in horticulture. A follow-up study in the Danish Occupational Hospitalization Register.

    abstract::The possible association between employment in horticulture with potential exposure to pesticides and female infertility was examined by identification of women with hospital contact due to infertility and working in horticulture through the Danish Occupational Hospitalization Register. This follow-up study gave a sta...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.04.036

    authors: Hougaard KS,Hannerz H,Feveile H,Bonde JP,Burr H

    更新日期:2009-04-01 00:00:00

  • Improved semen quality in subfertile males with varicocele-associated oligospermia following treatment with clomiphene citrate.

    abstract::Varicocelectomy has been found to improve the spermogram in many subfertile men. However, there still remains a sizable group of subfertile men whose counts fail to improve sufficiently following surgery. Clomiphene citrate, which has been shown to improve fertility in idiopathic oligospermia, was similarly tried in m...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)44661-3

    authors: Check JH

    更新日期:1980-04-01 00:00:00

  • Screening for 21-hydroxylase-deficient nonclassic adrenal hyperplasia among hyperandrogenic women: a prospective study.

    abstract:OBJECTIVE:To prospectively establish the specificity, sensitivity, and positive predictive value (PPV) of a basal 17-hydroxyprogesterone (17-HP) level for the screening of 21-hydroxylase-deficient nonclassic adrenal hyperplasia (NCAH) among hyperandrogenic women. DESIGN:Prospective observational trial. SETTING:Tertia...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(99)00383-0

    authors: Azziz R,Hincapie LA,Knochenhauer ES,Dewailly D,Fox L,Boots LR

    更新日期:1999-11-01 00:00:00

  • Reconstruction of the ovary containing large endometriomas by an extraovarian endosurgical technique.

    abstract:OBJECTIVE:To describe and evaluate the surgical treatment of large ovarian endometriomas by an extraovarian endosurgical technique. DESIGN:Prospective case series study. SETTING:University center and tertiary referral center for endoscopic surgery. PATIENTS:Patients with large ovarian endometriomas. INTERVENTION:A ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)58561-6

    authors: Brosens IA,Van Ballaer P,Puttemans P,Deprest J

    更新日期:1996-10-01 00:00:00

  • Parental attitudes toward disclosure of the mode of conception to their child conceived by in vitro fertilization.

    abstract:OBJECTIVE:To survey the level of disclosure of conception method within families of children conceived by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and to examine the factors that might influence parental attitudes and plans for disclosure. DESIGN:In-depth questionnaire. SET...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2004.12.019

    authors: Peters C,Kantaris X,Barnes J,Sutcliffe A

    更新日期:2005-04-01 00:00:00

  • Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.

    abstract:OBJECTIVE:To assess the effect of on-demand intranasal oxytocin administration on female sexual function and activity. DESIGN:Randomized, prospective, double-blind, placebo-controlled, crossover trial with duration of 22 weeks. SETTING:Academic medical center. PATIENT(S):Thirty pre-and postmenopausal women with sexu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.fertnstert.2015.06.010

    authors: Muin DA,Wolzt M,Marculescu R,Sheikh Rezaei S,Salama M,Fuchs C,Luger A,Bragagna E,Litschauer B,Bayerle-Eder M

    更新日期:2015-09-01 00:00:00

  • Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow.

    abstract:OBJECTIVE:To investigate the role of sonographic parameters in assessing endometrial receptivity in an in vitro fertilization (IVF) program. DESIGN:Prospective clinical study. SETTING:University setting. PATIENT(S):One hundred thirty-five patients in our IVF program, selected prospectively on the day of oocyte retri...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(00)01695-2

    authors: Schild RL,Knobloch C,Dorn C,Fimmers R,van der Ven H,Hansmann M

    更新日期:2001-02-01 00:00:00

  • Sonographic assessment of endometrial pattern and thickness in patients treated with clomiphene citrate, human menopausal gonadotropins, and intrauterine insemination.

    abstract:OBJECTIVE:To analyze the endometrium sonographically in patients undergoing controlled ovarian stimulation with clomiphene citrate (CC) in addition to menotropins to determine the significance of endometrial pattern and thickness on pregnancy rate (PR). DESIGN:A prospective study analyzing patients receiving sequentia...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)81509-9

    authors: Hock DL,Bohrer MK,Ananth CV,Kemmann E

    更新日期:1997-08-01 00:00:00

  • Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary syndrome.

    abstract:OBJECTIVE:To evaluate the effect of growth differentiation factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15) on the development of follicles among patients with polycystic ovary syndrome (PCOS). DESIGN:Case-control study. SETTING:University Hospital. PATIENT(S):Twenty-two oocytes were obtained from 15 pati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2009.03.014

    authors: Zhao SY,Qiao J,Chen YJ,Liu P,Li J,Yan J

    更新日期:2010-06-01 00:00:00

  • Inhibition of ovarian luteinizing hormone (LH) and follicle-stimulating hormone receptor levels with an LH-releasing hormone agonist during the estrous cycle in the rat.

    abstract::A single injection of the luteinizing hormone (LH)-releasing hormone (LHRH) agonist [D-Ala6,des-Gly-NH2(10)]LHRH ethylamide to female rats on diestrus I produced a marked reduction in ovarian LH/human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH) receptor levels, uterine weight, and plasma proges...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)43524-7

    authors: Kledzik GS,Cusan L,Auclair C,Kelly PA,Labrie F

    更新日期:1978-09-01 00:00:00

  • Histologic analysis of endometriomas: what the surgeon needs to know.

    abstract:OBJECTIVE:To evaluate by thorough pathologic analysis the histologic features of the endometrioma wall excised at laparoscopy. DESIGN:Prospective series of consecutive patients. SETTING:Tertiary care, university hospital. PATIENT(S):Fifty-nine patients with ovarian endometriomas. A total of 70 cysts were examined. ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.fertnstert.2006.06.055

    authors: Muzii L,Bianchi A,Bellati F,Cristi E,Pernice M,Zullo MA,Angioli R,Panici PB

    更新日期:2007-02-01 00:00:00

  • Levels and associations among self-esteem, fertility distress, coping, and reaction to potentially being a genetic carrier in women with diminished ovarian reserve.

    abstract:OBJECTIVE:To measure the level of distress and its relationship with other psychologic factors in women with diminished ovarian reserve (DOR) who participated in a fragile X genetics study. DESIGN:Longitudinal data analyzed with structural equation modeling. SETTING:Four U.S. private and academic fertility centers. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2013.02.033

    authors: Cizmeli C,Lobel M,Franasiak J,Pastore LM

    更新日期:2013-06-01 00:00:00

  • Comparison of three computer methods of sperm head analysis.

    abstract:OBJECTIVE:Analysis of sperm heads using three different computer morphometrical tools and experimental conditions to find a more reliable and secure strategy among them. DESIGN:Controlled experiments on sperm morphology analysis from volunteers. SETTING:Laboratory of microscopy and imaging processing. PATIENT(S):Ten...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(03)00978-6

    authors: Goulart AR,de Alencar Hausen M,Monteiro-Leal LH

    更新日期:2003-09-01 00:00:00

  • Efficacy of the second micro-testicular sperm extraction after failed first micro-testicular sperm extraction in men with nonobstructive azoospermia.

    abstract:OBJECTIVE:To evaluate the efficacy of the second micro-testicular sperm extraction (TESE)in men with nonobstructive azoospermia in whom the first micro-TESE failed. DESIGN:Retrospective. SETTING:Private clinic. PATIENT(S):One hundred twenty-five men with nonobstructive azoospermia with failed previous micro-TESE. Th...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2020.10.005

    authors: Özman O,Tosun S,Bayazıt N,Cengiz S,Bakırcıoğlu ME

    更新日期:2020-12-23 00:00:00

  • Older first-time mothers and early postpartum depression: a prospective cohort study of women conceiving spontaneously or with assisted reproductive technologies.

    abstract:OBJECTIVE:To evaluate whether older first-time mothers (≥37 years) have higher rates of postpartum depression compared with younger first-time mothers, controlling for mode of conception and known risk factors for postpartum depression. DESIGN:Prospective cohort study. SETTING:Assisted reproductive technology (ART) c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2011.08.037

    authors: McMahon CA,Boivin J,Gibson FL,Fisher JR,Hammarberg K,Wynter K,Saunders DM

    更新日期:2011-11-01 00:00:00

  • An effective "water injection"-assisted method for excision of ovarian endometrioma by laparoscopy.

    abstract:OBJECTIVE:To introduce an effective approach for excision of ovarian endometrioma by "water injection"-assisted laparoscopy treatment. DESIGN:Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique, approved by the Shengjing Hospital o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2019.05.014

    authors: Zhang NN,Sun TS,Yang Q

    更新日期:2019-09-01 00:00:00

  • Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.

    abstract:OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2009.02.055

    authors: Cruz MR,Prestes JC,Gimenes DL,Fanelli MF

    更新日期:2010-06-01 00:00:00

  • Immunologic challenges of human reproduction: an evolving story.

    abstract::Characterization of the implanting human fetus as an allograft prompted a field of research in reproductive immunology that continues to fascinate and perplex scientists. Paternal- or partner-derived alloantigens are present in the maternal host at multiple times during the reproductive process. They begin with exposu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2016.07.1073

    authors: Hyde KJ,Schust DJ

    更新日期:2016-09-01 00:00:00

  • Reconstruction of ooplasm recipient oocytes with frozen-thawed donor microcytoplasts and influence on the microtubular spindle.

    abstract:OBJECTIVE(S):To cryopreserve micromanipulated ooplast segments (microcytoplasts) from mouse oocytes, compare microcytoplast and parent or recipient oocyte fusion performed within or without the zona pellucida, compare electrofusion of fresh or frozen oocyte with frozen-thawed microcytoplasts, and assess spindle integri...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.07.1529

    authors: Goud AP,Goud PT,Diamond MP,Gonik B,Dozortsev DI,Hughes MR

    更新日期:2007-04-01 00:00:00

  • Low-dose aspirin in reproductive health: effects on menstrual cycle characteristics.

    abstract:OBJECTIVE:To estimate the effect of daily 81 mg low-dose aspirin (LDA) on menstrual cycle length and hormone profiles. DESIGN:Secondary analysis of a trial evaluating the effect of daily LDA or placebo on live birth among women with one or two previous pregnancy losses. SETTING:University medical centers. PATIENT(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2020.06.022

    authors: Evans MB,Nobles CJ,Kim K,Hill MJ,DeCherney AH,Silver RM,Mumford SL,Sjaarda LA,Perkins NJ,Schisterman EF

    更新日期:2020-12-01 00:00:00

  • Inherited thrombophilia in infertile women: implication in unexplained infertility.

    abstract::Many studies evaluating a possible relationship between inherited thrombophilia and the etiology of unexplained infertility have been performed recently. No significant difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G2021...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2009.10.014

    authors: Casadei L,Puca F,Privitera L,Zamaro V,Emidi E

    更新日期:2010-07-01 00:00:00

  • Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.

    abstract:OBJECTIVE:To evaluate the association between FSH efficacy and FSHR alleles. DESIGN:Retrospective study. SETTING:University-based fertility unit and a private center for biomedical research. PATIENT(S):One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were ca...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(03)00795-7

    authors: de Castro F,Ruiz R,Montoro L,Pérez-Hernández D,Sánchez-Casas Padilla E,Real LM,Ruiz A

    更新日期:2003-09-01 00:00:00

  • Expression of BET genes in testis of men with different spermatogenic impairments.

    abstract:OBJECTIVE:To characterize the BET gene expression in human testis with spermatogenetic impairments; to examine BRDT protein expression in testis and semen. DESIGN:Prospective study. SETTING:Fertility clinic. PATIENT(S):Azoospermic men (n = 120) who underwent testicular sperm extraction and who were classified as eit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2011.10.010

    authors: Barda S,Paz G,Yogev L,Yavetz H,Lehavi O,Hauser R,Botchan A,Breitbart H,Kleiman SE

    更新日期:2012-01-01 00:00:00

  • Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review.

    abstract:OBJECTIVE:To report an update on the role of vitamin D (VD) in ovarian physiology with a focus on genes involved in steroidogenesis, follicular development, and ovarian reserve, as well as ovulatory dysfunction associated with polycystic ovary syndrome (PCOS), and ovarian response to assisted reproductive technology (A...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2014.04.046

    authors: Irani M,Merhi Z

    更新日期:2014-08-01 00:00:00