Abstract：
OBJECTIVE:To study the changes in semen parameters, gonadotropic and sex hormones, and serum leptin in obese fertile and infertile oligozoospermic men. DESIGN:Prospective. SETTING:University hospital. PATIENT(S):Forty-two obese fertile and 80 obese infertile oligozoospermic men (body mass index [BMI] >30). INTERVENTION(S):The BMI calculation, semen analysis, and serum FSH, LH, T, E(2), PRL, and leptin estimation. MAIN OUTCOME MEASURE(S):Semen and hormonal profiles. RESULT(S):Obese oligozoospermic patients had significant increase in mean BMI, serum FSH, LH, E(2), PRL, and leptin compared with obese fertile controls. The BMI had significant positive correlation with abnormal sperm morphology, LH, serum leptin and significant negative correlation with sperm concentration, sperm motility, serum T. Serum leptin demonstrated significant positive correlation with patients' age, abnormal sperm morphology, serum FSH, LH, PRL and significant negative correlation with sperm concentration, sperm motility, and serum T. CONCLUSION(S):Serum leptin mediates a link between obesity and male infertility.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Hofny ER,Ali ME,Abdel-Hafez HZ,Kamal Eel-D,Mohamed EE,Abd El-Azeem HG,Mostafa Tdoi
10.1016/j.fertnstert.2009.03.085subject
Has Abstractpub_date
2010-07-01 00:00:00pages
581-4issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(09)00755-9journal_volume
94pub_type
杂志文章abstract：:Polycystic ovary syndrome (PCOS) is a highly prevalent disorder effecting reproductive-aged women worldwide. This article addresses the evolution of the criteria used to diagnosis PCOS; reviews recent advances in the phenotypic approach, specifically in the context of the extended Rotterdam criteria; discusses limitat...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2016.05.003
更新日期：2016-07-01 00:00:00
abstract：:Many will agree that the use of laparoscopy to diagnose and potientially treat endometriosis in patients who suffer from infertility has been superseded by IVF and sometimes oocyte donation, especially in older patients. The findings of our study add another dimension to management of endometriosis in the setting of i...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章,评审
doi：10.1016/j.fertnstert.2005.06.033
更新日期：2005-12-01 00:00:00
abstract：:The interaction of medroxyprogesterone acetate (MPA) with cortisol binding to corticosteroid-binding globulin (CBG) was studied with the use of an aqueous two-phase system with polyethylene glycol and dextran for equilibrium partition. Competitive binding analyses were also performed for progesterone (P), levonorgestr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48612-7
更新日期：1985-06-01 00:00:00
abstract：OBJECTIVE:To evaluate surgical sperm retrieval rates in adolescents with Klinefelter syndrome and testosterone replacement therapy (TRT). DESIGN:Case series. SETTING:Academic medical center. PATIENT(S):Ten patients with Klinefelter syndrome, aged 14-22 years, treated with testosterone replacement and aromatase inhib...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.06.010
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of blastocyst culture and transfer in human in vitro fertilization (IVF) as compared to day 3 embryo transfer. DESIGN:Prospective randomized trial. SETTING:Private assisted reproduction unit. PATIENT(S):A total of 162 IVF patients were included in the day 3 embryo transfer (n = 82)...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(01)02939-9
更新日期：2002-01-01 00:00:00
abstract：:Rabbits were immunized with homologous spermatozoa to investigate their autoimmunogenic nature. Major sperm autoantigens that elicit antisperm antibodies were analyzed molecularly by the sodium dodecylsulfate (SDS) gel/protein blot radioimmunobinding method. IgG fractions of the autoimmune sera were purified by a prot...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The aim of this study was to ascertain whether an interrelationship exists between gonadal steroids and the inhibition of gonadotropin secretion by dopamine. The effect of dopamine infusion (4 micrograms/kg/minute intravenously) on gonadotropin plasma levels in four castrated men (18 to 23 years of age) and in four ag...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48273-7
更新日期：1984-12-01 00:00:00
abstract：:The authors review the current approach to management of the adolescent varicocele which has evolved over the past two decades. Principles of observational, surgical and adjunctive management are discussed relative to significant clinical findings. A selective approach to surgical intervention is advocated with the go...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2011.10.034
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To determine the human endometrial transcriptome during embryonic implantation. DESIGN:Case report. SETTING:Tertiary fertility center. PATIENT(S):A 24-year-old woman who inadvertently became pregnant during an endometrial biopsy procedure. INTERVENTION(S):An endometrial biopsy was performed with a Pipelle...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.08.057
更新日期：2010-01-01 00:00:00
abstract：:In young women receiving chemotherapy for Hodgkin's disease, the combined use of triptorelin and tibolone cotreatment may be a useful tool for preserving ovarian function because all but three (10%) of the women in this treatment group returned to spontaneous ovulation and menses, in contrast to 23% of subjects in the...
journal_title：Fertility and sterility
pub_type： 信件
doi：10.1016/j.fertnstert.2006.10.004
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:To investigate the diagnostic relevance of serum cytokine concentrations in ectopic pregnancy (EP). DESIGN:Cohort study. SETTING:University hospital. PATIENT(S):Seventeen women with EP, 22 women with miscarriage, and 33 women with normal intrauterine pregnancy, at comparable stages of gestation. INTERVENT...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04853-7
更新日期：2003-04-01 00:00:00
abstract：:This prospective study evaluated the efficacy of transvaginal ultrasonography combined with water-contrast in the rectum (RWC-TVS) in the diagnosis of rectal infiltration in 35 women with rectovaginal endometriosis; ultrasonographic findings were compared with surgery and histology. The sensitivity of RWC-TVS in ident...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1336
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To improve the sperm chromatin dispersion (SCD) test and develop it as a simple kit (Halosperm kit) for the accurate determination of sperm DNA fragmentation using conventional bright-field microscopy. DESIGN:Method development, comparison, and validation. SETTING:Medical genetics laboratory, academic biolo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.11.089
更新日期：2005-10-01 00:00:00
abstract：:The effects of freezing and thawing (F/T) on functional activity of immature rat oocyte-cumulus complexes (OCC) were studied. The OCC were divided into three groups according to the number of cumulus-cell layers surrounding them. The OCC were then frozen and thawed (F/T), with dimethyl sulfoxide (DMSO) as cryoprotecta...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
abstract：OBJECTIVE:To determine the effects of dietary carrots and retinoic acid on P secretion in the in vitro perfused rabbit ovary. DESIGN:Controlled experiment. SETTING:Laboratory. SUBJECTS:Sexually mature New Zealand white rabbits. INTERVENTION(S):Experiments were done in vitro using an isolated rabbit ovarian perfusio...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81529-4
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:To assess the value of the hypo-osmotic swelling test in predicting fertilization, pregnancy, implantation, miscarriage, and live birth rates in IVF-ET cycles. DESIGN:Prospective study. SETTING:Academic tertiary referral center for fertility treatment. PATIENTS:Three hundred twenty-six couples having IVF-E...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58511-2
更新日期：1996-09-01 00:00:00
abstract：:We have examined the effects of prolactin (PRL) on progesterone (P) and estradiol (E2) synthesis by cells obtained from human corpora lutea of early and midluteal phases. The cells were cultured in the presence or absence of low (200 mIU/l) or high levels (1000 mIU/l) of PRL. Basal P, but not E2 was significantly (P l...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：OBJECTIVE:To determine whether patients support a mandatory single blastocyst transfer (mSBT) policy in IVF. DESIGN:Prospective survey study. SETTING:Academic hospital-based infertility center. PATIENT(S):Two hundred sixty-two female patients presenting for fresh or cryopreserved/thawed ET after IVF. INTERVENTION(S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.07.1140
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:To search for mutations in the coding exons of the follistatin gene of women diagnosed with polycystic ovary syndrome (PCOS). DESIGN:Controlled clinical study. SETTING:Tertiary institutional hospital. PATIENT(S):Thirty-four women diagnosed with PCOS and 15 healthy control women. INTERVENTION(S):Whole bloo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01697-1
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:To quantify the risk of recurrent early pregnancy loss in the presence of elevated fasting or afterload homocysteine concentrations or homozygosity for the 677C-->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (T/T genotype). DESIGN:Case-control studies published between January 1992 and ...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析
doi：10.1016/s0015-0282(00)01595-8
更新日期：2000-12-01 00:00:00
abstract：:Different protocols using agonists of GnRH-a have been proposed for the ovarian stimulation in IVF cycles. In case of stimulation failure with the flare-up protocol, we have investigated whether an immediate switch to pituitary blockade by the long-acting analog may avoid the cycle to be canceled. This procedure allow...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53536-5
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of carrying a BRCA1 or BRCA2 mutation on the probability of experiencing premature natural menopause. DESIGN:Observational study. SETTING:Patients in an academic research environment. PATIENT(S):Women who carry a BRCA1 or BRCA2 mutation (case subjects) and women who do not carry a mu...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2013.01.109
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). DESIGN:Prospective study in normal and PCOS women. SETTING:General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Mass...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.11.109
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To assess the predictive value of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in follicular fluid (FF) and serum for ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation. DESIGN:Retrospective, case-control study. SETTING:...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.09.044
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To report three cases of interstitial pregnancies treated successfully by combining uterine artery embolization (UAE) and ultrasound-guided local administration of methotrexate (MTX); and to assess the effect of UAE on ovarian reserve by prospectively measuring serum antimüllerian hormone (AMH) levels. DESIG...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.03.087
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:To evaluate which factor, AMH or FSH, was superior in predicting live birth after assisted reproductive technologies (ART) when the tests are discordant, using data from the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System database. DESIGN:Retrospective cohort. SETTING:Clinic-...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.03.022
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens. DESIGN:Prospective study. SETTING:Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France. PATIENT(S):Forty-seven infertile men lacking at least one vas deferens. INTERVENTI...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)02954-0
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the incidence of monozygotic twinning (MZT) in pregnancies conceived after blastocyst transfer compared to cleavage-stage transfer. DESIGN:Retrospective study. SETTING:University IVF program. PATIENT(S):All IVF patients with viable pregnancies conceived during a 4-year period. INTERVENTION(S):...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04754-4
更新日期：2003-03-01 00:00:00
abstract：:Reducing exposure to toxic environmental agents is a critical area of intervention for obstetricians, gynecologists, and other reproductive health care professionals. Patient exposure to toxic environmental chemicals and other stressors is ubiquitous, and preconception and prenatal exposure to toxic environmental agen...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.08.043
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:The present study investigates the effect of prenatal hyperandrogenization on lipid metabolism and oxidant/antioxidant balance. DESIGN:Experimental study. SETTING:Research institute. ANIMAL(S):Pregnant Sprague Dawley rats were subcutaneously injected with 2 mg free T between days 16 and 19 of pregnancy, an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.10.017
更新日期：2013-02-01 00:00:00
