Abstract:
OBJECTIVE:To evaluate surgical sperm retrieval rates in adolescents with Klinefelter syndrome and testosterone replacement therapy (TRT). DESIGN:Case series. SETTING:Academic medical center. PATIENT(S):Ten patients with Klinefelter syndrome, aged 14-22 years, treated with testosterone replacement and aromatase inhibitor therapy for a period of 1-5 years before surgical sperm retrieval. INTERVENTION(S):Microsurgical testis sperm extraction with cryopreservation of harvested tissue. MAIN OUTCOME MEASURE(S):Presence of spermatozoa within testis tissue. RESULT(S):Successful sperm retrieval in 7/10 patients (70%). CONCLUSION(S):Use of topical TRT did not appear to suppress spermatogenesis in adolescents with KS. It is uncertain whether sperm retrieval rates would be higher or lower without testosterone replacement in these young males. Sperm cryopreservation should be discussed in all KS adolescents who are either receiving or considering initiating TRT.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Mehta A,Bolyakov A,Roosma J,Schlegel PN,Paduch DAdoi
10.1016/j.fertnstert.2013.06.010subject
Has Abstractpub_date
2013-10-01 00:00:00pages
970-4issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(13)00704-8journal_volume
100pub_type
杂志文章abstract::To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticoste...
journal_title:Fertility and sterility
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.082
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To describe the use of Essure microinsert placement in patients with hydrosalpinges before IVF. DESIGN:Retrospective case-series. SETTING:An advanced endoscopic practice within a university-affiliated teaching hospital. PATIENT(S):Five women with unilateral or bilateral hydrosalpinges on transvaginal ultra...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.01.050
更新日期:2007-12-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
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更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To develop an understanding of hypogonadal men with a history of anabolic-androgenic steroid (AAS) use and to outline recommendations for management. DESIGN:Review of published literature and expert opinions. Intended as a meta-analysis, but no quality studies met the inclusion criteria. SETTING:Not applica...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2014.02.002
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To define the hypersensitive status of PRL secretion in normoprolactinemic infertile women and determine the incidence of occult hyperprolactinemia among them. DESIGN:The potential for PRL secretion was examined in 463 women. SETTING:Outpatient clinic in a university hospital. PATIENTS:Three hundred sixty-...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56154-8
更新日期:1993-09-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45620-7
更新日期:1981-07-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.01.063
更新日期:2007-12-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2005.05.074
更新日期:2006-01-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.03.047
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To investigate cell invasiveness and the production of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 in endometrial stromal cells (ESCs) of adenomyosis. DESIGN:Prospective study. SETTING:Tertiary university hospital. PATIENT(S):Twenty-one women with ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.05.090
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To describe two cases of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) with testicular sperm in men with immotile cilia syndromes. DESIGN:Case report. SETTING:A university-based male infertility clinic and assisted reproduction unit. PATIENT(S):Two couples with male factor infert...
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pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.03.069
更新日期:2006-12-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.06.030
更新日期:2004-02-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2007.02.022
更新日期:2008-01-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
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更新日期:2010-11-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.02.006
更新日期:2007-10-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53050-7
更新日期:1989-11-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2005.06.036
更新日期:2005-12-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
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更新日期:1979-12-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
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journal_title:Fertility and sterility
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:Fertility and sterility
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更新日期:2015-11-01 00:00:00
abstract::The effects of various doses of indomethacin and ketoprofen as compared with placebo were examined in 100 oligospermic patients who participated in this study. It was found that the treatment increased sperm count, sperm motility, and fertilizing capacity. The radioimmunoassay examination showed an increase in plasma ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)48081-7
更新日期:1984-09-01 00:00:00