Abstract:
OBJECTIVE:The present study examines the safety, effectiveness, and local tissue response for a new transcervical fallopian tube permanent contraceptive device, the STOP device (Conceptus, Inc., San Carlos, CA). DESIGN:Nonrandomized prospective evaluation of tubal occlusion and histologic response. SETTING:Inpatient, university and university-affiliated medical centers in the United States and Mexico. PATIENT(S):Premenopausal and perimenopausal women with benign indications for hysterectomy who were able to defer their hysterectomy for 1 to 13 weeks. INTERVENTION(S):A transcervically placed microcoil (STOP device) was inserted into the fallopian tubes of women who were scheduled for hysterectomy, and the device was worn for 1 to 12 weeks. At hysterectomy, hysterosalpingography was done to determine tubal occlusion; subsequently, the tubes containing the STOP devices were processed, sectioned, and evaluated to determine the histologic response. MAIN OUTCOME MEASURE(S):Ability to place a device and evaluate tubal occlusion and tissue response. RESULT(S):Devices were placed in 33 women, representing 57 tubes; the women wore the devices from 1 day to 30 weeks. Histology on 27 women (47 tubes) showed an acute inflammatory and fibrotic response in the short term that, over time, became a chronic inflammatory response with extensive fibrosis. CONCLUSION(S):The localized tissue response and notable absence of any normal tubal architecture in the segment of the fallopian tube containing the STOP device supports the postulated mechanisms of action of the device. Prehysterectomy study findings suggest the usefulness of the STOP device for pregnancy prevention, this is being evaluated in long-term safety and effectiveness studies.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Valle RF,Carignan CS,Wright TC,STOP Prehysterectomy Investigation Group.doi
10.1016/s0015-0282(01)02858-8keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
974-80issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(01)02858-8journal_volume
76pub_type
杂志文章abstract::Where histology used the presence of glands and/or stroma in the myometrium as pathognomonic for adenomyosis, imaging uses the appearance of the myometrium, the presence of striations, related to the presence of endometrial tissue within the myometrium, the presence of intramyometrial cystic structures and the size an...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2018.01.006
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To determine whether absence of fertilization in IVF associated with an acrosomal enzyme defect (hyaluronidase deficiency) results from a simple mechanical block to sperm penetration or from a more serious sperm abnormality. DESIGN:Nonrandomized, prospective study. SETTING:Toronto Center for Advanced Reprod...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::The aim of this study was to investigate the effects of pure genistein therapy on asymmetric dimethylarginine in healthy postmenopausal women. Healthy postmenopausal women received pure genistein (n=21) or placebo (n=17) for 6 months, and no statistically significant effects on plasma asymmetric dimethylarginine level...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2009.09.057
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To determine efficacy and safety of asoprisnil in patients with leiomyomata. DESIGN:Phase 2, multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-group study. SETTING:Twenty-eight sites in the United States and 1 in Canada. PATIENT(S):One hundred twenty-nine women with leiomyoma...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.fertnstert.2006.11.094
更新日期:2007-06-01 00:00:00
abstract::Endometriosis has been associated with corpus luteum inadequacy and abnormalities of luteal phase progesterone (P) secretion. In this study, abnormal luteolysis, as a second factor of luteal dysfunction, was assessed in 13 women with endometriosis and 25 control patients by measurement of ovarian vein estradiol (E2) a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59224-3
更新日期:1987-06-01 00:00:00
abstract::The circulating levels of leptin and neuropeptide Y, which are both involved in the control of feeding and reproduction, were measured in amenorrheic and normal cycling highly trained women athletes, and in normal cycling sedentary controls. Leptin showed similar low values in all athletes, whereas neuropeptide Y leve...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.08.041
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To induce apoptosis of endometriotic cells of patients with endometriosis. DESIGN:To demonstrate that polyglycolic acid/chitosan glue directly inhibits cell proliferation by inducing apoptosis. SETTING:University hospital infertility center. PATIENT(S):Twelve women who visited the center for infertility th...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.01.127
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To describe a novel mutation in the fumarate hydratase (FH) gene in a family with atypical uterine leiomyomas. DESIGN:Case report and review of the literature. SETTING:Academic community hospital. PATIENT(S):Three sisters who presented as nulligravidas aged 27-30 years with large atypical uterine leiomyoma...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.034
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the use of sonohysterography for uterine screening before IVF. DESIGN:Prospective screening with sonohysterography and comparison with available hysterosalpingographic and hysteroscopic evaluations. SETTING:Private practice. PATIENT(S):Seventy-two women undergoing IVF-ET using their own or dono...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00045-4
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To demonstrate the laparoscopic neuroanatomy of the autonomic nerves of the pelvis using the laparoscopic neuronavigation technique, as well as the technique for a nerve-sparing radical endometriosis surgery. DESIGN:Step-by-step explanation of the technique using videos and pictures (educational video) to de...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.07.1138
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To observe the ultrastructure of human oocytes at different maturity stages and morphologies before and after in vitro maturation. DESIGN:Case report. SETTING:University-based center for human reproduction. PATIENT(S):A 28-year-old patient with polycystic ovary syndrome undergoing IVM/IVF-ET treatment. IN...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.02.010
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To investigate the relative differences in outcomes among microdissection testicular sperm extraction (micro-TESE), conventional testicular sperm extraction (cTESE), and testicular sperm aspiration (TESA) in men with nonobstructive azoospermia. DESIGN:Systematic review and meta-analysis. SETTING:Outpatient ...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2015.07.1136
更新日期:2015-11-01 00:00:00
abstract::There is a paucity of data concerning the factors involved in the growth of uterine leiomyomata. The expression of mRNAs encoding EGF and the EGF receptor in myometrial and leiomyoma cultures suggest that EGF may be involved in the autocrine/paracrine regulation of human uterine leiomyomata and myometrial growth. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54681-0
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:To demonstrate a safe and effective approach to the treatment of obstructing midline prostate utricle cyst with the use of a holmium laser. DESIGN:Video presentation. SETTING:University hospital. PATIENT(S):A 33-year-old man presented with chronic pelvic pain, pain with ejaculation, and infertility. Semen ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2018.08.051
更新日期:2018-12-01 00:00:00
abstract::Twenty-four women who had undergone total salpingectomy due to ectopic pregnancy and who subsequently underwent a laparotomy for a second ectopic pregnancy in their opposite tube were treated by the author. Treatment consisted of linear salpingostomy (n = 20) and partial salpingectomy (n = 4). The intrauterine pregnan...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60025-0
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:To evaluate expression of interleukin-1 receptor type I in the endometrium of fertile women throughout the menstrual cycle and to investigate whether unexplained infertility may be associated with abnormal expression of IL-1 receptor type I. DESIGN:Retrospective study using immunohistochemical technique, Wes...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)01634-4
更新日期:2001-01-01 00:00:00
abstract::Combined therapy with clomiphene and intranasal luteinizing hormone-releasing hormone (LHRH) was used to induce ovulation in eight chronically anovulatory patients under treatment for infertility. Clomiphene, 100 mg daily, was given from the 5th to the 9th day of the cycle. Synthetic LHRH was administered intranasally...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVES:To determine if the total motile sperm count is predictive of IUI success and to apply life-table analysis to a large database of IUI procedures. DESIGN:Contingency table and life-table analyses were used to analyze a large group of couples (n = 546) undergoing 1,205 cycles of therapeutic IUI with husband's...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56831-9
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:To test, using the immunobead binding technique, for the presence of antisperm antibodies on epididymal sperm, in epididymal fluid, and in serum of men with congenital absence of the vas deferens. To evaluate the in vitro fertilization (IVF) capacity of human epididymal sperm in the presence of antisperm ant...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55451-x
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:To investigate the direct actions of active 1,25-dihydroxy vitamin D3 (VD3) upon primate follicular development at specific stages of folliculogenesis. DESIGN:Secondary preantral follicles were isolated from rhesus monkeys ovaries, encapsulated in alginate, and cultured for 40 days. Follicles were randomly a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.08.037
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To optimize the management of patients with cancer in a single testis and azoospermia. DESIGN:Case report. SETTING:Reproductive biology department. PATIENT(S):Two male patients referred in an emergency context for gamete cryopreservation before castration for cancer in a single testis; the patients were az...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.07.1308
更新日期:2008-08-01 00:00:00
abstract::The authors studied the role of follicle-stimulating hormone (FSH) in luteal steroidogenesis by replacing gonadotropin-releasing hormone (GnRH) infusion with pure FSH 48 hours after ovulation in two hypogonadotropic patients. Plasma progesterone (P) and estradiol (E2) decreased after FSH administration. Human luteal c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60611-8
更新日期:1989-04-01 00:00:00
abstract::Follicular development was followed by echography during 18 menstrual cycles in 10 women volunteers. Results were correlated with changes in serum hormone levels, basal body temperature curves, and cervical mucus changes. The average follicular growth as measured from the time of echographic visualization was 0.3 cm/d...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)44592-9
更新日期:1980-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficiency of using a continuous (one-step) protocol with a single medium for the culture of human embryos in a time-lapse incubator (TLI). DESIGN:Prospective cohort study on sibling donor oocytes. SETTING:University-affiliated in vitro fertilization (IVF) center. PATIENT(S):Embryos from 59...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2015.11.038
更新日期:2016-03-01 00:00:00
abstract::Varicocelectomy has been found to improve the spermogram in many subfertile men. However, there still remains a sizable group of subfertile men whose counts fail to improve sufficiently following surgery. Clomiphene citrate, which has been shown to improve fertility in idiopathic oligospermia, was similarly tried in m...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)44661-3
更新日期:1980-04-01 00:00:00
abstract::Recent in vitro studies implicate the ovary as an extra-hepatic source of insulin-like growth factors (IGFs) with production regulated by gonadotropins and local steroids. Because previous studies have failed to show any significant variations in IGF levels in peripheral blood during the menstrual cycle, we measured t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53221-x
更新日期:1990-01-01 00:00:00
abstract::The amino acid and protein composition of human follicular fluid, obtained during surgery from women with polycystic ovaries, and of a simultaneously obtained sample of blood plasma were studied. In general, amino acid concentrations were higher in follicular fluid than in blood plasma: only the concentration of Cys w...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42324-1
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy and safety of Repronex SC as compared with Repronex IM and Pergonal IM in patients undergoing IVF. DESIGN:Open-label, randomized, parallel-group, multicenter study. SETTING:Fifteen academic and private fertility clinics with IVF experience. PATIENT(S):Premenopausal women with regu...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0015-0282(00)00605-1
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:Immunobead testing (IBT), the current standard for antisperm antibody detection, is time consuming and somewhat subjective. To overcome these limitations and maintain accuracy, we studied an immunofluorescent assay using flow cytometry. DESIGN:A validation study comparing flow cytometry to IBT in the detecti...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To develop a technique with the potential of isolating genetically fit sperm for assisted reproductive technology (ART) treatment without compromising its structural or functional competence. DESIGN:Observational study. SETTING:University hospital. PATIENT(S):Fifty patients undergoing infertility diagnosis...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.10.047
更新日期:2015-02-01 00:00:00