Abstract:
OBJECTIVE:To determine efficacy and safety of asoprisnil in patients with leiomyomata. DESIGN:Phase 2, multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-group study. SETTING:Twenty-eight sites in the United States and 1 in Canada. PATIENT(S):One hundred twenty-nine women with leiomyomata. INTERVENTION(S):Asoprisnil (5, 10, or 25 mg) or placebo orally daily for 12 weeks. MAIN OUTCOME MEASURE(S):Uterine bleeding changes by using daily bleeding diaries, hemoglobin concentrations, dominant leiomyoma and uterus volume measured sonographically, patient-reported symptoms related to bloating and pelvic pressure, endometrial thickness and morphology, hormonal parameters, and standard safety measures. RESULT(S):Asoprisnil suppressed uterine bleeding in 28%, 64%, and 83% of subjects at 5, 10, and 25 mg, respectively, and reduced leiomyoma and uterine volumes. Median percentage decrease from baseline in leiomyoma volume was statistically significant at 25 mg compared with placebo after 4 and 8 weeks of treatment; by week 12, leiomyoma volume was reduced by 36%. There was a significant reduction in bloating with the two highest doses and in pelvic pressure with 25 mg by week 12. Asoprisnil was associated with follicular-phase estrogen concentration and minimal hypoestrogenic symptoms. CONCLUSION(S):After 12-week treatment, asoprisnil controlled uterine bleeding while reducing leiomyoma volume and the associated pressure symptoms. Asoprisnil was well tolerated.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Chwalisz K,Larsen L,Mattia-Goldberg C,Edmonds A,Elger W,Winkel CAdoi
10.1016/j.fertnstert.2006.11.094subject
Has Abstractpub_date
2007-06-01 00:00:00pages
1399-412issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(06)04533-Xjournal_volume
87pub_type
杂志文章,多中心研究,随机对照试验abstract::The rapid postpartum return of gonadotropic function during bromocriptine treatment was investigated through hormonal measurements in 15 women. Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG). Prolactin was effectively suppressed by ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60610-6
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:To assess the endocrine, paracrine, and autocrine milieu in patients with endometriosis on the basis of the measurement of several cytokines in serum and follicular fluid (FF) and in vitro culture of granulosa luteal cells. DESIGN:Case-control study. SETTING:In vitro fertilization program at the Instituto V...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00204-0
更新日期:1998-09-01 00:00:00
abstract::This document provides a general overview for physicians of the qualities and conditions necessary for good management practices within the endocrinology, andrology, and embryology laboratories in the United States. It is intended as an addendum to previously published guidelines that further detail these responsibili...
journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.fertnstert.2014.06.036
更新日期:2014-10-01 00:00:00
abstract::Standardized bilateral ovarian-adrenal vein catheterization was utilized to assess directly glandular steroid release in 60 androgenized women without evidence of a functional neoplasm. Testosterone (T), dihydrotestosterone (DHT), androstenedione (delta 4 A), dehydroepiandrosterone (DHEA), DHEA sulfate (DHEA-S), 17-hy...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47960-4
更新日期:1984-07-01 00:00:00
abstract:OBJECTIVE:To assess the relative efficacy, in terms of clinical pregnancy rates (PRs), of transuterotubal insemination versus the more traditional intrauterine insemination (IUI) procedure. DESIGN:Prospective, randomized, cross-over. SETTING:University-affiliated tertiary care center. PATIENTS:One hundred sixty infe...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To present a case report of a unilateral triplet ectopic pregnancy (EP) conceived by IVF-embryo transfer. DESIGN:Case report. SETTING:University Hospital, Budapest, Hungary. PATIENT(S):A 26-year-old infertile woman with a history of right salpingectomy, hyperprolactinemia, and male factor infertility under...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.018
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To review published data and to compare pregnancy rates (PRs) after culturing human embryos with and without glucose and phosphate. DESIGN:Comparison of results from various programs. SETTING:Assisted Reproductive Technology Program. PATIENT(S):Patients were enrolled in various studies. INTERVENTION(S):Hu...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00052-1
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of treating women with severe menstrual migraine headaches with GnRH agonist (GnRH-a) therapy, alone and combined with continuous estrogen-progestin "add-back." DESIGN:Nonrandomized, prospective treatment study. SETTING:Outpatient clinic in a university medical center. PATIENT(S):...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/S0015-0282(97)81928-0
更新日期:1997-02-01 00:00:00
abstract::The antiprogesterone compound RU 486 (17 beta-hydroxy-11 beta-[4-dimethylaminophenyl]-17 alpha-[ 1-propynyl]estra-4,9-dien-3-one; Roussel-Uclaf, Paris, France) was used to induce menstruation in a randomized controlled trial. Castrated adult female cynomolgus monkeys (n = 17) received sequential subcutaneous Silastic ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47246-8
更新日期:1983-08-01 00:00:00
abstract::We conducted a case-control study and compared the results of IVF treatment in two groups of women with polycystic ovaries. The first group consisted of 42 women who were previously treated unsuccessfully with in vitro maturation (IVM), and the second group, 48 others with no previous IVM (control group). We included ...
journal_title:Fertility and sterility
pub_type: 信件
doi:10.1016/j.fertnstert.2009.09.033
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility. DESIGN:Secondary data analysis of a randomized controlled trial. SETTING:Academic medical center associated with a private infert...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2013.11.008
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To determine whether high ligation is an effective treatment for infertile men with clinical varicocele. DESIGN:A randomized, controlled trial of high spermatic vein ligation was carried out. The patients were treated and observed for 3 years. SETTING:Infertility treatment clinic and andrology laboratory in...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0015-0282(16)57306-3
更新日期:1995-01-01 00:00:00
abstract::Mean monthly values for ejaculate volume, sperm density, and percentage of motile sperm were calculated from semen analyses performed on volunteered donors to the laboratory from 1979 to 1986. The data of 4,196 ejaculates were computerized by the single Cosinor method for searching on circannual rhythms of the paramet...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60738-0
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To report a case of severe ovarian hyperstimulation syndrome (OHSS) after inadvertent GnRH long protocol/hMG stimulation in a pre-existing early pregnancy. DESIGN:Case report. SETTING:Private infertility clinic. PATIENT(S):A 28-year-old woman who conceived spontaneously following IVF and cryo-embryo transf...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.05.069
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To report a case of complete androgen insensitivity syndrome (CAIS) with Müllerian duct persistence. DESIGN:Case report. SETTING:Academic hospital. PATIENT(S):A case of CAIS at 20 weeks' gestational age, and three male and one female 20-week-old fetuses for comparison. INTERVENTION(S):DNA screening for an...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.09.028
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To compare the effects of the aromatase inhibitor letrozole (7.5 mg) and clomiphene citrate (CC; 100 mg) in women undergoing superovulation and IUI. DESIGN:Prospective randomized trial. SETTING:University teaching hospital. PATIENT(S):We studied a total of 238 cycles of superovulation and IUI in women with...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2004.04.070
更新日期:2004-12-01 00:00:00
abstract::The data from 83 consecutive in vitro fertilization-embryo transfer cycles were examined with emphasis on the presence of subfertile male parameters, including abnormal sperm density, motility, morphologic features, or an abnormal result in the sperm penetration assay (zona-free hamster ova penetration). There were 25...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)49338-6
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:To analyze the endometrium sonographically in patients undergoing controlled ovarian stimulation with clomiphene citrate (CC) in addition to menotropins to determine the significance of endometrial pattern and thickness on pregnancy rate (PR). DESIGN:A prospective study analyzing patients receiving sequentia...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81509-9
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:To examine the reproductive outcome after operative hysteroscopic resection of submucous myomas in women for whom no other infertility factor was identified. DESIGN:Fifteen infertile women with submucous myomas underwent an intensive workup to exclude other causes of infertility. Operative hysteroscopy for r...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57844-3
更新日期:1995-10-01 00:00:00
abstract::The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome affects between 2% and 5% of hirsute women and is characterized by INS resistance, elevated INS levels, acanthosis nigricans, and androgen excess. These patients' response to therapy is unclear, although long-acting GnRH-a suppression has been propose...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:To analyze sonographically the endometrium in patients undergoing controlled ovarian stimulation with menotropins in order to determine the significance of endometrial pattern and thickness on pregnancy rate. DESIGN:This is a prospective, nonrandomized study comparing pregnancy rates in patients with hyperec...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)58447-7
更新日期:1996-08-01 00:00:00
abstract::A study was undertaken to examine the influence of pH on the migration of X and Y sperm as observed in freshly ejaculated semen samples from human donors. These sperm were allowed to migrate into capillary tubes containing media of varying pH. Y-carrying sperm were i dentified using flourescent staining with quinacr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)38224-3
更新日期:1971-05-01 00:00:00
abstract:OBJECTIVE:To further understand the association between semen quality and cancer risk by means of well defined semen parameters. DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 20,433 men who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.10.027
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of infectious complications and the protective effect of prophylactic antibiotic treatment after diagnostic office hysteroscopy in asymptomatic, infertile patients with normal results from transvaginal sonography. DESIGN:Recording of infectious complications after routine hysteroscop...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.fertnstert.2010.08.031
更新日期:2011-02-01 00:00:00
abstract::In 1951 it was shown that human spermatozoa contained cytochromes a, b, and c. It was noted that the cytochromes were confined to the sperm and were not found in seminal fluid. More recently we have observed in seminal plasma a soluble component that has a typical spectrum of a reduced cytochrome b, but can be disting...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:To introduce a combined laparovaginal metroplasty approach to the treatment of bicornuate uterus. DESIGN:Case report. SETTING:Private community hospital. PATIENT:A nulliparous patient with three recurrent spontaneous midtrimester abortions and a double uterus on hysterosalpingogram was evaluated laparoscop...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58235-1
更新日期:1996-04-01 00:00:00
abstract::In summary, the luteal phase defect is a deficiency of corpus luteum progesterone steroidogenesis, either in amount or duration, or both. The clinical manifestations include either primary infertility or repeated first trimester abortions. The diagnosis can only be made clinically on the basis of a well-timed endometr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)41769-3
更新日期:1976-04-01 00:00:00
abstract::It is the responsibility of the clinician to assess for the presence of erectile dysfunction, ejaculatory dysfunction, or diminished libido related to hypoandrogenism among men presenting with a primary complaint of infertility. Referral to a reproductive urologist or other appropriate specialist with requisite expert...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2018.07.010
更新日期:2018-10-01 00:00:00
abstract::Both EST and Mayer-Rokitansky-Kuster-Hauser syndrome are uncommon disorders. This report illustrates a case of these two rare conditions occurring in the same patient. Patients with Mayer-Rokitansky-Kuster-Hauser syndrome, although not appearing to be at increased risk for germ cell tumors, unlike testicular feminizat...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54562-2
更新日期:1991-09-01 00:00:00
abstract::Surgical ablation of the inferior mesenteric plexus in the rat results in an excessive accumulation of sperm within the cauda epididymidis. The present study examined the effect of ablation of the inferior mesenteric plexus on the motility of cauda epididymal spermatozoa. One to 8 weeks after ablation of the inferior ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00