当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation.

Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation.

Abstract：

:To investigate the mechanism of the antifertility action of sulfasalazine, we prospectively measured sperm density, motility, hamster oocyte penetration capacity, and reactive oxygen species production in six men with inflammatory bowel disease being treated with sulfasalazine and 8 and 16 weeks after changing to 5-aminosalicylic acid (5-ASA). An improvement was observed after changing to 5-ASA in those with poor (n = 3), but not in those with normal (n = 3), sperm function on sulfasalazine. There was no correlation between reactive oxygen species production or acetylator phenotype with egg penetration capacity, sperm motility, or sperm density. We conclude that the mechanism of impairment and recovery of sperm function on and off sulfasalazine treatment is not related to an excess in reactive oxygen species.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Wu FC,Aitken RJ,Ferguson A

doi

10.1016/s0015-0282(16)53050-7

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

842-5

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)53050-7

journal_volume

52

pub_type

杂志文章

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