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Ulipristal acetate decreases transforming growth factor β3 serum and tumor tissue concentrations in patients with uterine fibroids.

Abstract：

OBJECTIVE:To evaluate and compare transforming growth factor β3 (TGF-β3) serum concentration in patients with uterine fibroids (UFs) without hormone treatment, treated with ulipristal acetate (UPA), and controls; to evaluate TGF-β3 concentrations in UF tissue in patients without hormone treatment and those treated with UPA; and to evaluate the correlations of age and body mass index (BMI) with TGF-β3 serum and UF tissue levels between the groups. DESIGN:Retrospective cohort study. SETTING:University teaching hospital. PATIENT(S):A total of 141 patients divided into three groups: UFs non-UPA, UFs, and UPA, controls. INTERVENTION(S):Medical history and examination, genital ultrasound scan, blood and tissue sampling, and measurement of TGF-β3 serum and tissue concentrations. MAIN OUTCOME MEASURE(S):Evaluation of the impact of UPA (3 months treatment), age and BMI on TGF-β3 serum and UF tissue levels. RESULT(S):The values of TGF-β3 serum and tissue concentrations statistically significantly differed between the non-UPA and UPA groups. The mean TGF-β3 serum concentrations were non-UPA group 32.24 ± 34.55 pg/mL, UPA group 10.88 ± 7.15 pg/mL, and controls 11.97 ± 10.30 pg/mL. The mean TGF-β3 tissue concentrations were non-UPA group 171.29 ± 91.81 pg/mg and UPA group 99.99 ± 60.63 pg/mg. Statistically significantly lower mean TGF-β3 serum and tissue concentrations were observed in patients treated with UPA. No statistically significant correlations between TGF-β3 concentrations and age or BMI were found. CONCLUSION(S):Reduction of serum and tissue TGF-β3 concentrations in UFs may be an important component of the effect of UPA on UF biology. Further research in this area is necessary.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Ciebiera M,Włodarczyk M,Wrzosek M,Słabuszewska-Jóźwiak A,Nowicka G,Jakiel G

doi

10.1016/j.fertnstert.2017.11.023

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

501-507.e2

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(17)32077-0

journal_volume

109

pub_type

杂志文章

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