当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations.

Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations.

Abstract：

OBJECTIVE:To evaluate the efficacy of methotrexate treatment in selected cases of extrauterine pregnancy (EUP) defined by stable or increasing hCG concentration. DESIGN:Prospective cohort study. SETTING:Gynecology department of the Lis Maternity Hospital. PATIENT(S):Fifty women with EUP diagnosed whenever an intrauterine gestational sac was not seen on transvaginal ultrasonography. INTERVENTION(S):Women received IM methotrexate at a dose of 50 mg/m(2) of body surface area. Failure of hCG levels to fall by >/=15% during any successive week resulted in repeated administration of methotrexate. Surgical intervention was performed for presumed tubal rupture. MAIN OUTCOME MEASURE(S):Serial hCG measurement was performed weekly until hCG concentration reached 15 mIU/mL. Success was defined as the achievement of hCG concentration of 25 mIU/mL without surgical intervention. RESULT(S):Forty-four women (88%) were successfully treated. The mean time from first methotrexate injection to success was 34 +/- 2.4 days. Women treated successfully and unsuccessfully differed significantly only with regard to serum hCG levels of 1,876 +/- 243 and 3,489 +/- 376 mIU/mL, respectively. When the initial hCG levels were lower or higher than 2,000 IU/L, the success rate was 97% and 74%, respectively (significant by Fisher's exact test). CONCLUSION(S):When methotrexate treatment is administrated in a selected group of EUP defined by stable or increasing hCG, it may fail more frequently (26%) when initial hCG levels are >2,000 mIU/mL.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Gamzu R,Almog B,Levin Y,Avni A,Jaffa A,Lessing JB,Baram A

doi

10.1016/s0015-0282(01)03256-3

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

761-5

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015028201032563

journal_volume

77

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Effect of rosiglitazone on spontaneous and clomiphene citrate-induced ovulation in women with polycystic ovary syndrome.

    abstract：OBJECTIVE:In women suffering from polycystic ovary syndrome (PCOS), correction of hyperinsulinemia results enhances spontaneous ovulation or alternatively, the responsiveness to ovulation induction agents such as clomiphene citrate (CC). We investigated the effect of rosiglitazone maleate on ovulation induction in over...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(02)04843-4

    authors： Ghazeeri G,Kutteh WH,Bryer-Ash M,Haas D,Ke RW

    更新日期：2003-03-01 00:00:00

  • Results of ovulation induction using human menopausal gonadotropin or purified follicle-stimulating hormone in hypogonadotropic hypogonadism patients.

    abstract：OBJECTIVE:To compare ovarian performance and hormonal levels, after ovulation induction, in patients with isolated hypogonadotropic hypogonadism, using two different gonadotropin drugs. DESIGN:Patients were treated during consecutive cycles, using the same stimulation protocol, with human menopausal gonadotropin (hMG)...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(16)54715-3

    authors： Shoham Z,Balen A,Patel A,Jacobs HS

    更新日期：1991-12-01 00:00:00

  • Gonadotropin-releasing hormone antagonist administration enhances gonadotrope responsiveness at doses inadequate to suppress immunoassayable gonadotropin levels.

    abstract：:Chronic GnRH antagonist therapy produces enhanced gonadotrope responsiveness to supraphysiologic stimuli despite the lack of any measurable suppression of gonadotropin levels. This indicates that GnRH antagonists fundamentally alter gonadotrope response mechanisms without inhibiting gonadotropin release. Beyond the ph...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Scott RT Jr,Illions EH,Carey KD,Navot D

    更新日期：1994-11-01 00:00:00

  • Implications in the maintenance of pregnancy: I. Presence of immunoreactive glycodelin in human umbilical cord vein endothelial cells.

    abstract：OBJECTIVE:We previously reported an antipeptide antibody to human glycodelin that recognizes glycodelin in amniotic fluid and epithelial glands of the endometrium. The objective of this study was to determine the presence of glycodelin in human umbilical cord. DESIGN:Controlled clinical study. SETTING:Healthy women u...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(99)00599-3

    authors： Kim JG,Ramachandran S,Zhou HM,Rayner D,Parthasarathy S

    更新日期：2000-04-01 00:00:00

  • Evaluation of the semi-automated Autosperm semen analysis system. II. Comparison with conventional method, time-exposure photomicrography, and automated CellSoft system.

    abstract：:Semen analysis results obtained by a recently developed semi-automated Autosperm system (Amsaten N.V.S.A. Corp., De Pinte, Belgium) were compared with those obtained by the conventional, time-exposure photomicrographic, and automated CellSoft system (Cryo Resources Inc., New York, NY) analyses. The Autosperm system ei...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Chan SY,Zhang GH,Leung A,Ng M,Wang C

    更新日期：1990-01-01 00:00:00

  • Pubertal development of the first cohort of young adults conceived by in vitro fertilization in the United States.

    abstract：OBJECTIVE:To characterize pubertal development of the first generation of young adults born as a result of in vitro fertilization (IVF). Demographic, clinical, and body size characteristics were examined regarding developmental milestones. DESIGN:Cross-sectional. SETTING:Academic center. PATIENT(S):Young adults (18-...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.04.057

    authors： Beydoun HA,Sicignano N,Beydoun MA,Bocca S,Stadtmauer L,Oehninger S

    更新日期：2011-02-01 00:00:00

  • Comparison of embryo morphokinetics after in vitro fertilization-intracytoplasmic sperm injection in smoking and nonsmoking women.

    abstract：OBJECTIVE:To evaluate the impact of female smoking on early embryo development in vitro using a time-lapse system. DESIGN:Retrospective analysis of prospectively collected database. SETTING:Assisted reproductive technology (ART) program. PATIENT(S):A total of 135 infertile couples undergoing IVF-intracytoplasmic spe...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2013.01.136

    authors： Fréour T,Dessolle L,Lammers J,Lattes S,Barrière P

    更新日期：2013-06-01 00:00:00

  • The clinical value of salpingoscopy in tubal infertility.

    abstract：:A specially designed rigid salpingoscope has been developed to allow inspection of the tubal mucosa during laparoscopy. The presence and extent of intratubal adhesion formation can be evaluated more accurately by this technique than by either HSG or laparoscopy. In 22 patients with bilateral hydrosalpinges, an intraut...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60501-0

    authors： De Bruyne F,Puttemans P,Boeckx W,Brosens I

    更新日期：1989-02-01 00:00:00

  • Virtual hysterosalpingography in the diagnosis of bicornuate versus septate uterus.

    abstract：OBJECTIVE:To study the value of virtual hysterosalpingography (VHSG) in the diagnosis of bicornuate vs. septate uterus. DESIGN:Retrospective study of all cases with bicornuate or septate uterus that had VHSG during the last 3 years at our center. SETTING:Private fertility center and radiology institute with universit...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.08.026

    authors： Carrascosa P,Sueldo C,Capuñay C,Baronio M,Papier S

    更新日期：2011-11-01 00:00:00

  • In vitro fertilization outcomes in patients experiencing a premature rise in luteinizing hormone during a gonadotropin-releasing hormone antagonist cycle.

    abstract：:Patients undergoing controlled ovarian hyperstimulation and pituitary suppression with a GnRH antagonist who experienced a transient premature rise in LH were compared with those who did not have an early surge. Those experiencing a premature LH surge had equivalent clinical and ongoing pregnancy rates per ET. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.12.046

    authors： Kummer NE,Weitzman VN,Benadiva CA,Schmidt DW,Engmann LL,Nulsen JC

    更新日期：2011-06-30 00:00:00

  • Platelet-activating factor-acether is a component of human follicular fluid.

    abstract：OBJECTIVE:Platelet-activating factor-acether (PAF-acether) presence was investigated in 27 human follicular fluids (FFs). DESIGN:Aggregation of washed rabbit platelets was used to measure PAF-acether. Data were compared using Student's t-test. SETTING:Follicular fluids came from the in vitro fertilization program at ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54417-3

    authors： Amiel ML,Testart J,Benveniste J

    更新日期：1991-07-01 00:00:00

  • Environmentally relevant levels of bisphenol A affect uterine decidualization and embryo implantation through the estrogen receptor/serum and glucocorticoid-regulated kinase 1/epithelial sodium ion channel α-subunit pathway in a mouse model.

    abstract：OBJECTIVE:To investigate whether bisphenol A (BPA) exposure is associated with uterine decidualization and embryo implantation failure in mice. DESIGN:Experimental animal study and in vitro study. SETTING:University-based infertility center. ANIMAL(S):ICR mice. INTERVENTION(S):Mice treated with different doses of B...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2017.12.003

    authors： Yuan M,Hu M,Lou Y,Wang Q,Mao L,Zhan Q,Jin F

    更新日期：2018-04-01 00:00:00

  • Comparison of low-dose human menopausal gonadotropin and micronized 17beta-estradiol supplementation in in vitro maturation cycles with thin endometrial lining.

    abstract：OBJECTIVE:A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer. DESIGN:Retrospective study. SETTING:McGill Reproductive Center, Montreal, Canada. PATIENT(S):Women with endometrial thickness <6 mm on days 6-10 ultrasound (US) scan of ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.07.1750

    authors： Elizur SE,Son WY,Yap R,Gidoni Y,Levin D,Demirtas E,Tan SL

    更新日期：2009-09-01 00:00:00

  • Association between sperm autoantibodies and enhanced embryo implantation rates during in vitro fertilization.

    abstract：:Previous investigations have demonstrated the propensity of strong IgA-class sperm autoantibodies to impede fertilization. However, because there has not been a general consensus on this issue, the aim of this retrospective analysis was to focus on the effects of different levels of IgA-class antibodies on each stage ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.02.089

    authors： Clarke GN

    更新日期：2006-09-01 00:00:00

  • Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells.

    abstract：OBJECTIVE:To determine whether estrogen down-regulates MCP-1 in vascular endothelial cells. DESIGN:A prospective comparative study. SETTING:Academic research environment. PATIENT(S):Human umbilical vein endothelial cells (n = 3) and human coronary artery endothelial cells (n = 3) obtained from females. INTERVENTION...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)03223-x

    authors： Seli E,Pehlivan T,Selam B,Garcia-Velasco JA,Arici A

    更新日期：2002-03-01 00:00:00

  • Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis.

    abstract：OBJECTIVE:To evaluate basal (constitutive) and stimulated synthesis of tumor necrosis factor alpha (TNF alpha), interleukin (IL)-8, IL-10 by peritoneal macrophages (PM) in women with endometriosis. DESIGN:Peritoneal macrophages were cultured in the presence or absence of lipopolysaccharide (LPS) for 24 hours. Peritone...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Rana N,Braun DP,House R,Gebel H,Rotman C,Dmowski WP

    更新日期：1996-05-01 00:00:00

  • Torsion of the fallopian tube and acute pelvic pain: an unusual presentation of genital tuberculosis.

    abstract：:A case of a genital tuberculosis found during laparoscopic evaluation for recurrent acute pelvic pain is presented. The symptoms of genital tuberculosis can vary greatly, and a laparoscopic approach is effective for making the diagnosis. Clinicians should consider tuberculosis as a differential diagnosis when encounte...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.09.063

    authors： Perez-Medina T,Bueno B,Redondo T,Gallego I,Bajo-Arenas J

    更新日期：2008-06-01 00:00:00

  • Reconstruction of ooplasm recipient oocytes with frozen-thawed donor microcytoplasts and influence on the microtubular spindle.

    abstract：OBJECTIVE(S):To cryopreserve micromanipulated ooplast segments (microcytoplasts) from mouse oocytes, compare microcytoplast and parent or recipient oocyte fusion performed within or without the zona pellucida, compare electrofusion of fresh or frozen oocyte with frozen-thawed microcytoplasts, and assess spindle integri...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.07.1529

    authors： Goud AP,Goud PT,Diamond MP,Gonik B,Dozortsev DI,Hughes MR

    更新日期：2007-04-01 00:00:00

  • Tamoxifen citrate therapy in male infertility.

    abstract：:A prospective, randomized, double-blind study with crossover, using tamoxifen (TAM) (Nolvadex, ici Pharma, Missisauga, Canada) 20 mg/day and placebo (p) for 6 months each, was conducted in 16 infertile men with idiopathic oligozoospermia. Baseline sperm count was 17.092 +/- 3.09 (10(6)/ml). Hormonal profile was perfor...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)59299-1

    authors： AinMelk Y,Belisle S,Carmel M,Jean-Pierre T

    更新日期：1987-07-01 00:00:00

  • Endometrial antigens involved in the autoimmunity of endometriosis.

    abstract：:Serum and peritoneal fluid from five fertile women without endometriosis and serum (n = 23) and peritoneal fluid (n = 12) from infertile women with endometriosis were tested for the presence of antibodies against endometrial tissue antigens by a Western blot analysis. Antigens with molecular weights (MW) of 19, 31, 38...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60362-x

    authors： Mathur S,Chihal HJ,Homm RJ,Garza DE,Rust PF,Williamson HO

    更新日期：1988-12-01 00:00:00

  • Bone density and reproductive hormones in patients with neuroleptic-induced hyperprolactinemia.

    abstract：:To study the prevalence of osteoporosis and hyperandrogenism in neuroleptic-induced hyperprolactinemia, the authors evaluated 10 patients. Three were amenorrheic, while seven had oligomenorrhea. Nine patients had galactorrhea. The Ferriman-Gallway hirsutism score was 12 +/- 2. Vaginal smear maturation value was 53 +/-...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60365-5

    authors： Ataya K,Mercado A,Kartaginer J,Abbasi A,Moghissi KS

    更新日期：1988-12-01 00:00:00

  • Detection of granulocyte colony-stimulating factor and its receptor in human follicular luteinized granulosa cells.

    abstract：OBJECTIVE:To evaluate concentration of granulocyte colony-stimulating factor (G-CSF) in serum and follicular fluid (FF) at the time of oocyte retrieval and to detect expression of G-CSF and its receptor by luteinized granulosa cells (GCs). DESIGN:Collection of serum and FF at the time of oocyte retrieval. SETTING:A u...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2003.09.039

    authors： Salmassi A,Schmutzler AG,Huang L,Hedderich J,Jonat W,Mettler L

    更新日期：2004-03-01 00:00:00

  • Twice-frozen embryos are no detriment to pregnancy success: a retrospective comparative study.

    abstract：OBJECTIVE:To compare the pregnancy rates (PR) and live birth rates in once- versus twice-frozen ET treatment cycles in the same cohort of women. DESIGN:A retrospective study. SETTING:Fertility clinics, IVF Australia, New South Wales. PATIENT(S):The study population was all women who underwent thawing of twice-frozen...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.04.034

    authors： Koch J,Costello MF,Chapman MG,Kilani S

    更新日期：2011-07-01 00:00:00

  • Therapeutic use of gonadoliberin (follicle-stimulating hormone/luteinizing hormone-releasing hormone) in women.

    abstract：:Certain conclusions may be drawn from the present review: 1. Synthetic FSH/LH-RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH-RH because of individual variations in response. 2. Gonado...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42188-6

    authors： Zárate A,Canales ES,Soria J,Forsbach G,Kastin AJ,Schally AV

    更新日期：1976-11-01 00:00:00

  • DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection.

    abstract：OBJECTIVE:To investigate differentially expressed genes in epithelial and stromal cells of eutopic endometrium from patients with deep endometriosis and women with normal pelvic cavities using laser capture microdissection and complementary DNA microarrays. DESIGN:Prospective study. SETTING:University hospital. PATI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2005.04.041

    authors： Matsuzaki S,Canis M,Vaurs-Barrière C,Boespflug-Tanguy O,Dastugue B,Mage G

    更新日期：2005-10-01 00:00:00

  • The zona pellucida-induced acrosome reaction of human spermatozoa is mediated by protein kinases.

    abstract：OBJECTIVE:To determine if the solubilized human zona pellucida (ZP)-induced acrosome reaction is mediated by protein kinases. DESIGN:Capacitated spermatozoa were incubated with inhibitors of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent kinase (KT5720), Ca(2+)- and phospholipid-dependent kinase (Calphostin C),...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Bielfeld P,Faridi A,Zaneveld LJ,De Jonge CJ

    更新日期：1994-03-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma and early folliculogenesis during an acute hyperandrogenism condition.

    abstract：:Acute hyperandrogenism decreases serum P levels and induces early apoptosis of antral follicles by a mechanism mediated by the peroxisome proliferator-activated receptor gamma system and independent of the steroidogenic acute regulator protein. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.07.1083

    authors： Faut M,Elia EM,Parborell F,Cugnata NM,Tesone M,Motta AB

    更新日期：2011-01-01 00:00:00

  • Cross-sectional analysis of the effects of age on the hormonal, metabolic, and ultrasonographic features and the prevalence of the different phenotypes of polycystic ovary syndrome.

    abstract：OBJECTIVE:To assess the effects of age on the hormonal, metabolic, and ultrasonographic features of polycystic ovary syndrome (PCOS). DESIGN:Observational study. SETTING:University department of obstetrics and gynecology. PATIENT(S):Patients with PCOS (n = 1,212) and healthy women (n = 254). INTERVENTION(S):None. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.11.041

    authors： Panidis D,Tziomalos K,Macut D,Delkos D,Betsas G,Misichronis G,Katsikis I

    更新日期：2012-02-01 00:00:00

  • Normal pregnancies resulting from testicular sperm extraction and intracytoplasmic sperm injection for azoospermia due to maturation arrest.

    abstract：OBJECTIVE:To see whether testicular sperm extraction could be used to perform intracytoplasmic sperm injection (ICSI) for men with nonobstructive azoospermia caused by maturation arrest. DESIGN:Uncontrolled prospective trial of an attempt to find occasional elongated spermatids or spermatozoa in testes of azoospermic ...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(16)58396-4

    authors： Silber SJ,van Steirteghem A,Nagy Z,Liu J,Tournaye H,Devroey P

    更新日期：1996-07-01 00:00:00

  • What factors currently limit magnetic resonance-guided focused ultrasound of leiomyomas? A survey conducted at the first international symposium devoted to clinical magnetic resonance-guided focused ultrasound.

    abstract：OBJECTIVE:To see if clinicians' impressions were influenced by expert opinion on patient selection criteria that influence magnetic resonance-guided focused ultrasound (MRgFUS) leiomyoma treatment. DESIGN:Survey-based study. SETTING:First international symposium devoted to MRgFUS, "MRgFUS 2008," October 6-7, 2008, Wa...

    journal_title：Fertility and sterility

    pub_type：

    doi：10.1016/j.fertnstert.2009.02.083

    authors： Taran FA,Hesley GK,Gorny KR,Stewart EA

    更新日期：2010-06-01 00:00:00