Platelet-activating factor-acether is a component of human follicular fluid.

Abstract:

OBJECTIVE:Platelet-activating factor-acether (PAF-acether) presence was investigated in 27 human follicular fluids (FFs). DESIGN:Aggregation of washed rabbit platelets was used to measure PAF-acether. Data were compared using Student's t-test. SETTING:Follicular fluids came from the in vitro fertilization program at Antoine Béclère Hospital, and PAF-acether was assayed at Institut National de la Santé et de la Recherche Médicale, Unités 187 and 200, Clamart, France. PATIENTS, PARTICIPANTS:The study concerned five infertile women 29 to 39 years of age. INTERVENTIONS:Ovaries were stimulated with human menopausal gonadotropin under gonadotropin-releasing hormone agonist (GnRH-a) action. MAIN OUTCOME MEASURES:The height of platelet aggregation was compared between FFs and synthetic PAF-acether. RESULTS:Mean FF concentration of PAF-acether was 1,367 to 3,467 pg/mL among women. Values were higher for patients in a long than in a short GnRH-a protocol (P less than 0.05). However, PAF-acether concentration was not related to fertilization rate. CONCLUSIONS:Platelet-activating factor-acether is possibly involved in oocyte release from the follicle, a process occulted by follicular puncture.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Amiel ML,Testart J,Benveniste J

doi

10.1016/s0015-0282(16)54417-3

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

62-5

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54417-3

journal_volume

56

pub_type

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