当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > The impairment of reproduction in db/db mice is not mediated by intraovarian defective leptin signaling.

The impairment of reproduction in db/db mice is not mediated by intraovarian defective leptin signaling.

Abstract：

OBJECTIVE:To demonstrate whether leptin modulates reproduction by a direct effect within the ovary. DESIGN:Animal model. SETTING:National Key Laboratory of Infertility. ANIMAL(S):Adult female db/db mice. INTERVENTION(S):Adult littermate wild-type (WT) and diabetic (db) leptin receptor (LR) mutant female mice were matched for the allograft of the ovary to construct new genotypic models, respectively. WT mouse received only one ovary from a WT or a db/db mouse (WT Ov-WT, WT Ov-db), and db/db mouse received one ovary from a WT or a db/db mouse (db Ov-WT, db Ov-db). WT and db/db mice received one ovary from a WT mouse and another ovary from a db/db mouse (WT Ov-WT/db, db Ov-WT/db) or received two ovaries all from a WT mouse (db Ov-WT/WT). MAIN OUTCOME MEASURE(S):Hormones, lipids, and reverse transcription polymerase chain reaction. RESULT(S):Both WT Ov-WT and WT Ov-db mice presented normal cycles, comparable serum E(2) and FSH levels, and ovarian expressions of the Star, Cyp17, and Cyp19 mRNA, even with different ovary genotypes. In WT Ov-WT/db with hMG stimulation, db ovaries with LR mutation expressed higher Star, Cyp17, Cyp19, Jak2, Stat3, and Pias3 mRNA than in the basal state, whereas WT ovaries with intact LR expressed higher Star, Cyp17, and Cyp19 but divergently lower Jak2, Stat3, and Pias3 levels. CONCLUSION(S):We confirmed that impairment of reproduction in intact db/db mice is not mediated by intraovary intact/defective leptin signaling even in face of a divergent modulation by gonadotropins.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Zhang Y,Hu M,Ma H,Qu J,Wang Y,Hou L,Liu L,Wu XK

doi

10.1016/j.fertnstert.2012.01.126

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

1183-91

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)00185-9

journal_volume

97

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Implications in the maintenance of pregnancy: I. Presence of immunoreactive glycodelin in human umbilical cord vein endothelial cells.

    abstract：OBJECTIVE:We previously reported an antipeptide antibody to human glycodelin that recognizes glycodelin in amniotic fluid and epithelial glands of the endometrium. The objective of this study was to determine the presence of glycodelin in human umbilical cord. DESIGN:Controlled clinical study. SETTING:Healthy women u...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(99)00599-3

    authors： Kim JG,Ramachandran S,Zhou HM,Rayner D,Parthasarathy S

    更新日期：2000-04-01 00:00:00

  • Exacerbation of ovarian hyperstimulation by leuprolide reveals a gonadotroph adenoma.

    abstract：OBJECTIVE:To report a case of a gonadotroph adenoma diagnosed after a dramatic increase in estradiol level and ovarian hyperstimulation in response to a gonadotropin-releasing hormone agonist. DESIGN:Case report. SETTING:Outpatient practice and university hospital. PATIENT(S):A 35-year-old woman who presented with i...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)04342-x

    authors： Castelbaum AJ,Bigdeli H,Post KD,Freedman MF,Snyder PJ

    更新日期：2002-12-01 00:00:00

  • Evidence for association of the G1733A polymorphism of the androgen receptor gene with recurrent spontaneous abortions.

    abstract：OBJECTIVE:To determine whether the G1733A polymorphism of the androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). DESIGN:Case-control study. SETTING:Division of Genetics and Biotechnology, Department of Biology, University of Athens. PATIENT(S):A total of 131 women w...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.04.071

    authors： Karvela M,Stefanakis N,Papadopoulou S,Tsitilou SG,Tsilivakos V,Lamnissou K

    更新日期：2008-11-01 00:00:00

  • Blood carbon dioxide tension changes during hysteroscopy.

    abstract：:During hysteroscopy the uterus may be distended with carbon dioxide (CO2), nitrous oxide (N2O), or Hyskon (a high molecular weight dextran). An initial study in 27 patients (group 1) using arterialized venous blood samples demonstrated rises in carbon dioxide tension (PCO2) when N2O was insufflated by using a laparosc...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)44179-8

    authors： Hulf JA,Corall IM,Knights KM,Strunin L,Newton JR

    更新日期：1979-08-01 00:00:00

  • Selecting controls is not selecting "normals": design and analysis issues for studying the etiology of polycystic ovary syndrome.

    abstract：INTRODUCTION:Polycystic ovary syndrome (PCOS) is a highly prevalent disorder among postmenarcheal premenopausal women, accounting for much of anovulatory infertility, and it is associated with several comorbidities. The natural history of PCOS, as well as hypotheses regarding its etiology, facilitates employment of the...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2005.09.066

    authors： Bloom MS,Schisterman EF,Hediger ML

    更新日期：2006-07-01 00:00:00

  • Serum is more effective than albumin in promoting human embryo development and implantation.

    abstract：OBJECTIVE:To compare the effects of serum with those of Albuminar-5 (Armour Pharmaceutical Co., Eastbourne, Sussex, United Kingdom) as medium supplements to Earl's balanced salt solution (EBSS) for IVF and subsequent embryo development. DESIGN:A retrospective study. Gametes and embryos from 318 patients were cultured ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)57978-3

    authors： Hargreaves CA,Rahman F,Cowan D,Santis M,Keefe T,Howell RJ,Chard T,Homa ST

    更新日期：1995-12-01 00:00:00

  • Congenital Müllerian anomalies: diagnostic accuracy of three-dimensional ultrasound.

    abstract：OBJECTIVE:To determine whether it is possible to identify and diagnose accurately Müllerian anomalies with three-dimensional (3-D) ultrasound (US). DESIGN:Controlled blinded clinical study. SETTING:Normal human volunteers undergoing infertility evaluation in a university hospital. PATIENTS:Forty-two patients who und...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(16)58147-3

    authors： Raga F,Bonilla-Musoles F,Blanes J,Osborne NG

    更新日期：1996-03-01 00:00:00

  • Embryo transfer practices and multiple births resulting from assisted reproductive technology: an opportunity for prevention.

    abstract：OBJECTIVE:To evaluate assisted reproductive technology (ART) ET practices in the United States and assess the impact of these practices on multiple births, which pose health risks for both mothers and infants. DESIGN:Retrospective cohort analysis using the National ART Surveillance System data. SETTING:US fertility c...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2014.12.127

    authors： Kissin DM,Kulkarni AD,Mneimneh A,Warner L,Boulet SL,Crawford S,Jamieson DJ,National ART Surveillance System (NASS) group.

    更新日期：2015-04-01 00:00:00

  • Pelvic adhesions following microsurgical and macrosurgical wedge resection of the ovaries.

    abstract：:The incidence of postoperative adhesion formation following microsurgical and macrosurgical ovarian wedge resection was contrasted in 10 adult female rhesus monkeys. Bilateral wedge resection was performed on day 10 of the luteal phase using microsurgical technique on one ovary and macrosurgical technique contralatera...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)44723-0

    authors： Eddy CA,Asch RH,Balmaceda JP

    更新日期：1980-05-01 00:00:00

  • Echographic study of follicular maturation and ovulation during the normal menstrual cycle.

    abstract：:Follicular development was followed by echography during 18 menstrual cycles in 10 women volunteers. Results were correlated with changes in serum hormone levels, basal body temperature curves, and cervical mucus changes. The average follicular growth as measured from the time of echographic visualization was 0.3 cm/d...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)44592-9

    authors： Renaud RL,Macler J,Dervain I,Ehret MC,Aron C,Plas-Roser S,Spira A,Pollack H

    更新日期：1980-03-01 00:00:00

  • The relation of fertility and ovarian histology after bilateral ovarian wedge resection.

    abstract：:The immediate and long term fertility after bilateral ovarian wedge resection in 53 women with clomiphene citrate-resistant hyperandrogenic chronic anovulation is related to the histology of the ovarian wedges. Patients with polycystic ovaries and hyperplastic stromal abnormalities had most spontaneous conceptions and...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60845-2

    authors： Lappöhn RE,Bogchelman DH

    更新日期：1989-08-01 00:00:00

  • In vitro effects of phthalate esters in human myometrial and leiomyoma cells and increased urinary level of phthalate metabolite in women with uterine leiomyoma.

    abstract：OBJECTIVE:To investigate the possible role of phthalate, a ubiquitous chemical used in consumer products, in the pathogenesis of uterine leiomyoma. DESIGN:Experimental and prospective case-control study using human samples. SETTING:University hospital. PATIENT(S):Fifty-three women with histologic evidence of uterine...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2017.01.015

    authors： Kim JH,Kim SH,Oh YS,Ihm HJ,Chae HD,Kim CH,Kang BM

    更新日期：2017-04-01 00:00:00

  • Endometrial lesions caused by catheters used for embryo transfers: a preliminary report.

    abstract：OBJECTIVE:To visualize by microhysteroscopy any possible lesions on the endocervix and endometrium made by the catheters commonly used for embryo transfer (ET). DESIGN:Prospective descriptive study. Tertiary fertility center (IFER). PATIENT(S):Twenty-three infertile patients underwent a mock transfer before a microhy...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(03)00607-1

    authors： Marconi G,Vilela M,Belló J,Diradourián M,Quintana R,Sueldo C

    更新日期：2003-08-01 00:00:00

  • Preclinical abortions and endometriosis.

    abstract：:A single human chorionic gonadotropin determination was performed in 786 infertile women during the late luteal phase to determine the frequencies of preclinical abortions and whether the frequency was increased in women with endometriosis. Thirty-seven pregnancies (4.7% of cycles) were identified, of which six were c...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)59705-2

    authors： Pittaway DE,Ellington CP,Klimek M

    更新日期：1988-02-01 00:00:00

  • Oocyte donation: insights into implantation.

    abstract：OBJECTIVE:To ascertain whether obstetric, gynecologic, or congenital variables affect implantation efficiency or eventual delivery in donor oocyte recipients. DESIGN:Clinical study. SETTING:Academic tertiary care infertility clinic. PATIENT(S):A total of 370 recipients. INTERVENTION(S):Fresh ET following oocyte don...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(98)00420-8

    authors： Moomjy M,Cholst I,Mangieri R,Rosenwaks Z

    更新日期：1999-01-01 00:00:00

  • Tests of prolactin secretion in the diagnosis of hyperprolactinemic states: nomifensine and domperidone.

    abstract：:Forty-one subjects with hyperprolactinemia underwent testing on separate occasions with nomifensine, an indirectly acting dopamine agonist, and domperidone, a dopamine receptor-blocking agent. Nomifensine (200 mg orally) did not significantly modify plasma levels of prolactin (PRL) in 17 subjects in whom the existence...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)45314-8

    authors： Massara F,Genazzani AR,Camanni F,De Leo V,Molinatti GM,Müller EE

    更新日期：1981-02-01 00:00:00

  • Comparison of pregnancy rates for poor responders using IVF with mild ovarian stimulation versus conventional IVF: a guideline.

    abstract：:Mild-stimulation protocols with in vitro fertilization (IVF) generally aim to use less medication than conventional IVF. This guideline evaluates pregnancy and live-birth rates in patients expected to be poor responders using mild ovarian stimulation and natural-cycle protocols vs conventional IVF. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,实务指引

    doi：10.1016/j.fertnstert.2018.03.019

    authors： Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org.

    更新日期：2018-06-01 00:00:00

  • Posthumous assisted reproduction: a survey of attitudes of couples seeking fertility treatment and the degree of agreement between intimate partners.

    abstract：OBJECTIVE:To study attitudes about posthumous assisted reproduction (PAR) in individuals presenting for assisted reproduction, to examine the degree of concordance of attitudes within couples, and to determine whether individuals can accurately predict the attitudes of their intimate partners. DESIGN:Cross sectional s...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.09.018

    authors： Nakhuda GS,Wang JG,Sauer MV

    更新日期：2011-12-01 00:00:00

  • AZF microdeletions of the Y chromosome and in vitro fertilization outcome.

    abstract：OBJECTIVE:To determine whether the presence of a Y microdeletion confers any adverse effects on in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) outcome. DESIGN:Retrospective case-control study. SETTING:Academic infertility center. PATIENT(S):A total of 17 patients with Y microdeletions who atte...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2003.06.030

    authors： Choi JM,Chung P,Veeck L,Mielnik A,Palermo GD,Schlegel PN

    更新日期：2004-02-01 00:00:00

  • Quantification of mitochondrial DNA using real-time polymerase chain reaction in patients with premature ovarian failure.

    abstract：OBJECTIVE:To quantify mitochondrial DNA using real-time PCR in women with premature ovarian failure (POF) and a control group. DESIGN:Prospective study. SETTING:Genome Research Center for Reproductive Medicine and Infertility, Korea Ministry of Health & Welfare. PATIENT(S):Thrity patients with POF and 30 control ind...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2005.06.036

    authors： Cha KY,Lee SH,Chung HM,Baek KH,Cho SW,Kwack KB

    更新日期：2005-12-01 00:00:00

  • Spontaneous and prostaglandin- or oxytocin-induced motility of rat ovaries isolated during different stages of the estrous cycle: effects of norepinephrine.

    abstract：:Ovaries isolated from rats in different stages of the sex cycle were explored for spontaneous or drug-induced contractile activity. The number of spontaneously active ovaries as well as the magnitude of the isometrically developed tension and frequency of contractions were greater during the periovulatory interval (la...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)41724-3

    authors： Sterin-Borda L,Borda E,Gimeno MF,Gimeno AL

    更新日期：1976-03-01 00:00:00

  • Cost of ectopic pregnancy management: surgery versus methotrexate.

    abstract：OBJECTIVE:To estimate the potential annual cost savings of methotrexate (MTX) therapy for ectopic pregnancy (EP) at our institution and nationally. DESIGN:Retrospective. SETTING:San Francisco General Hospital. PATIENTS:All patients treated for EP in 1991. INTERVENTIONS:Medical records and billing statements were re...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Creinin MD,Washington AE

    更新日期：1993-12-01 00:00:00

  • Use of a specific zona pellucida (ZP) protein 3 antiserum as a clinical marker for human ZP integrity and function.

    abstract：OBJECTIVE:To evaluate binding characteristics of a specific zona pellucida (ZP) protein 3 (ZP3) antiserum to human oocytes in order to determine its usefulness as a clinical marker for human ZP integrity and function and its correlation with IVF outcome. DESIGN:Prospectively designed, blinded, internally controlled st...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)58041-8

    authors： Oehninger S,Hinsch E,Pfisterer S,Veeck LL,Kolm P,Schill WB,Hodgen GD,Hinsch KD

    更新日期：1996-01-01 00:00:00

  • Influence of progesterone on endometrial nitric oxide synthase expression.

    abstract：OBJECTIVE:To determine the effect of P on nitric oxide synthase (NOS) expression in human endometrial epithelial cells. DESIGN:Laboratory-based study. SETTING:University-based research institute. PATIENT(S):None. INTERVENTION(S):The effect of P on the expression of NOS protein isoforms was examined in an in vitro p...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.05.019

    authors： Khorram O,Han G

    更新日期：2009-05-01 00:00:00

  • Training in reproductive endocrinology and infertility and assisted reproductive technologies: options and worldwide needs.

    abstract：:Standardized, high-quality training in reproductive endocrinology, infertility, and assisted reproductive technologies (REI-ART) faces challenges owing to the high-tech nature of ART and the important country-to-country differences in clinical practice and regulations overseeing training. Moreover, while the training ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2015.04.031

    authors： de Ziegler D,de Ziegler N,Sean S,Bajouh O,Meldrum DR

    更新日期：2015-07-01 00:00:00

  • Cycle dependency of intrauterine vascular endothelial growth factor levels is correlated with decidualization and corpus luteum function.

    abstract：OBJECTIVE:To determine intrauterine levels of vascular endothelial growth factor (VEGF)-A during the menstrual cycle in the human female and to investigate the impact of decidualization and corpus luteum function. DESIGN:Prospective clinical study. SETTING:Tertiary university center. PATIENT(S):Fifty-four women with...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(03)02165-4

    authors： Licht P,Russu V,Lehmeyer S,Wissentheit T,Siebzehnrübl E,Wildt L

    更新日期：2003-11-01 00:00:00

  • Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.

    abstract：OBJECTIVE:To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. DESIGN:Prospec...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.09.019

    authors： Pertegal M,Fenoy FJ,Hernández M,Mendiola J,Delgado JL,Bonacasa B,Corno A,López B,Bosch V,Hernández I

    更新日期：2016-01-01 00:00:00

  • Oxytocin-induced cell growth proliferation in human myometrial cells and leiomyomas.

    abstract：OBJECTIVE:To assess the expression of the oxytocin receptor (OTR) and the role of oxytocin (OT) in the proliferation of myometrial and leiomyoma cells. DESIGN:Prospective laboratory study. SETTING:Research laboratory at the Italian National Research Council. PATIENT(S):Twenty-two women who underwent therapeutic myom...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.10.064

    authors： Busnelli M,Rimoldi V,Viganò P,Persani L,Di Blasio AM,Chini B

    更新日期：2010-10-01 00:00:00

  • Does cyclic human chorionic gonadotropin secretion indicate embryo loss in in vitro fertilization?

    abstract：:The human chorionic gonadotropin (hCG) beta subunit curve of normal singleton in vitro fertilization (IVF) pregnancies shows cyclic peaks during the first 56 days after embryo transfer (ET). This phenomenon is not demonstrable in normal spontaneous conceptions. The hCG curves of 151 singleton IVF pregnancies achieved ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Confino E,Demir RH,Friberg J,Gleicher N

    更新日期：1986-11-01 00:00:00

  • Zygote intrafallopian transfer or in vitro fertilization and embryo transfer for the treatment of male-factor infertility: a prospective randomized trial.

    abstract：OBJECTIVE:To compare zygote intrafallopian transfer (ZIFT) and in vitro fertilization and embryo transfer (IVF-ET) as treatments of male-factor infertility. DESIGN:Patients were prospectively randomized to ZIFT or IVF-ET. SETTING:In vitro fertilization program of the Centre for Reproductive Medicine of the Dutch-spea...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)55195-4

    authors： Tournaye H,Devroey P,Camus M,Valkenburg M,Bollen N,Van Steirteghem AC

    更新日期：1992-08-01 00:00:00