当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.

Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.

Abstract：

OBJECTIVE:To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. DESIGN:Prospective case-control study. SETTING:University hospital. PATIENT(S):A total of 53 preeclamptic and 72 normal pregnant women. INTERVENTION(S):Maternal and cord blood samples and placental tissue samples were obtained. MAIN OUTCOME MEASURE(S):Maternal and fetal COMT and MTHFR polymorphisms were genotyped. Maternal plasma 2-ME and homocysteine levels, and expression and activity of placental COMT were measured. RESULT(S):The odds ratio for the risk of preeclampsia for fetal COMT Met/Met was 3.22, and it increased to 8.65 when associated with fetal MTHFR TT. Placental COMT activity and expression were influenced by genotype, but COMT activity in preeclamptic placentas did not differ from control pregnancies. There was no association between any genotypes and maternal 2-ME. Homocysteine levels were higher in women with preeclampsia than in normal pregnancies, and were inversely correlated with 2-ME plasma levels, indicating that its altered metabolism may lower COMT activity in vivo. CONCLUSION(S):Fetal Met-Met COMT genotype reduces COMT placental expression and activity in vitro and increases preeclampsia, risk but it does not explain the difference in maternal 2-ME levels between preeclamptic and normal pregnancies. However, the preeclamptic patients had elevated homocysteine levels that correlated inversely with 2-ME, indicating that an altered methionine-homocysteine metabolism may contribute to reduce COMT activity in vivo and explain the decreased levels of 2-ME in preeclamptic women.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Pertegal M,Fenoy FJ,Hernández M,Mendiola J,Delgado JL,Bonacasa B,Corno A,López B,Bosch V,Hernández I

doi

10.1016/j.fertnstert.2015.09.019

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

134-43.e1-3

issue

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(15)01936-6

journal_volume

105

pub_type

杂志文章

在线工具

Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.