Zygote intrafallopian transfer or in vitro fertilization and embryo transfer for the treatment of male-factor infertility: a prospective randomized trial.

Abstract:

OBJECTIVE:To compare zygote intrafallopian transfer (ZIFT) and in vitro fertilization and embryo transfer (IVF-ET) as treatments of male-factor infertility. DESIGN:Patients were prospectively randomized to ZIFT or IVF-ET. SETTING:In vitro fertilization program of the Centre for Reproductive Medicine of the Dutch-speaking Brussels Free University, Belgium, which is a tertiary referral institution. PATIENTS:One hundred fifty-seven couples were enrolled in the study. Inclusion criteria allowed only first trials of couples with long-standing infertility caused by a male factor. Female factors were excluded. INTERVENTIONS:In ZIFT, up to three fertilized oocytes were transferred into one single patient fallopian tube by means of laparoscopy 18 hours after insemination. In IVF-ET, cleaving embryos were replaced into the uterine cavity about 48 hours after insemination. MAIN OUTCOME MEASURES:Fertilization and transfer rates, implantation and pregnancy rates, pregnancy outcome, and cost per procedure were evaluated. RESULTS:Implantation rates of 12.3% and 10% per replaced conceptus were achieved for ZIFT and IVF-ET, respectively. CONCLUSIONS:This study demonstrates no therapeutic advantage of ZIFT over IVF-ET in male-factor infertility in terms of reproductive outcome or economic benefit.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Tournaye H,Devroey P,Camus M,Valkenburg M,Bollen N,Van Steirteghem AC

doi

10.1016/s0015-0282(16)55195-4

keywords:

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

344-50

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)55195-4

journal_volume

58

pub_type

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