当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > In vitro effects of phthalate esters in human myometrial and leiomyoma cells and increased urinary level of phthalate metabolite in women with uterine leiomyoma.

In vitro effects of phthalate esters in human myometrial and leiomyoma cells and increased urinary level of phthalate metabolite in women with uterine leiomyoma.

Abstract：

OBJECTIVE:To investigate the possible role of phthalate, a ubiquitous chemical used in consumer products, in the pathogenesis of uterine leiomyoma. DESIGN:Experimental and prospective case-control study using human samples. SETTING:University hospital. PATIENT(S):Fifty-three women with histologic evidence of uterine leiomyoma and 33 surgical controls without leiomyoma. INTERVENTION(S):Human myometrial and leiomyoma cells were treated with di-(2-thylhexyl)-phthalate (DEHP). MAIN OUTCOME MEASURE(S):Cell viability assay and Western blot analyses after in vitro DEHP treatment; high-performance liquid chromatography electrospray ionization tandem mass spectrometry in cases and controls. RESULT(S):In vitro treatment with DEHP led to an increased viability and increased expressions of proliferating cell nuclear antigen, B-cell lymphoma 2 protein, and type I collagen in myometrial and leiomyoma cells. The urinary concentration of mono-(2-ethyl-5-carboxypentyl) phthalate was higher in women with leiomyoma compared with controls. CONCLUSION(S):These findings suggest that exposure to phthalate may play a role in the pathogenesis of uterine leiomyoma by enhancing proliferative activity, exerting an antiapoptotic effect, and increasing collagen contents in myometrial and leiomyoma cells.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kim JH,Kim SH,Oh YS,Ihm HJ,Chae HD,Kim CH,Kang BM

doi

10.1016/j.fertnstert.2017.01.015

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

1061-1069.e1

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(17)30058-4

journal_volume

107

pub_type

杂志文章

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