Abstract：
OBJECTIVE:To estimate the potential annual cost savings of methotrexate (MTX) therapy for ectopic pregnancy (EP) at our institution and nationally. DESIGN:Retrospective. SETTING:San Francisco General Hospital. PATIENTS:All patients treated for EP in 1991. INTERVENTIONS:Medical records and billing statements were reviewed. MAIN OUTCOME MEASURES:Direct costs were determined from billing statements, and indirect costs were estimated based on published data. Potential annual national cost savings from MTX treatment were then extrapolated using national statistics on the incidence of EP. RESULTS:Fifty EPs were treated with an average direct cost of $7,972 per case. Direct and indirect costs totaled > $500,000. Fifteen (30%) of the cases would have been eligible for MTX treatment with a resultant cost savings of > $160,000. The potential annual national cost savings would be in excess of $280 million. CONCLUSIONS:If preliminary findings suggesting the effectiveness of MTX as an alternative therapy for EP are confirmed, appropriate use of MTX will not only reduce morbidity but also the substantial cost.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Creinin MD,Washington AEsubject
Has Abstractpub_date
1993-12-01 00:00:00pages
963-9issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(16)56393-6journal_volume
60pub_type
杂志文章abstract：OBJECTIVE:To determine, for a woman aged >45 years, whether selected hormonal, health status, and demographic measures are related to the time to final menstrual period (FMP) from a point where 6 weeks separate the shortest and longest cycles experienced to date. DESIGN:Cohort study. SETTING:Volunteers in an academic...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03231-4
更新日期：2002-08-01 00:00:00
abstract：:Defects of the DNA mismatch repair gene hMLH3 were screened by denaturing high-performance liquid chromatography and sequencing in germinal tissue DNA from patients with spermatogenic arrest, with sequence variations being confirmed in genomic DNA by polymerase chain reaction (PCR) direct sequencing analysis. Four mis...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.01.063
更新日期：2007-12-01 00:00:00
abstract：:This article highlights a comprehensive range of research investigations which are required to clarify the relationships between the symptom of excessively heavy menstrual bleeding and different disorders of systemic hemostasis and their management. The need for these investigations was stimulated by an international ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2005.07.1268
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:To compare polyacrylamide gel as synthetic medium with human cervical mucus (CM) for the in vitro sperm-penetration test during infertility investigation. PATIENTS:One hundred sixty-nine randomly chosen couples with a median duration of infertility of 4 (range, 1 to 16) years presenting at the infertility un...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)56174-3
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:To document the changes in pain scores 3-12 months following ablative laparoscopic surgery. Secondary outcome measures included patient satisfaction scores. DESIGN:A prospective, cohort study. SETTING:A tertiary referral center for the treatment of endometriosis. PATIENT(S):Seventy-three consecutive women ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04957-9
更新日期：2003-05-01 00:00:00
abstract：:Live and dead spermatozoa of human semen were distinguished and evaluated separately with respect to their morphology after supravital staining with buffered eosin. This evaluation was shown to be almost as reliable as that of the commonly stained smear. Different samples from the same individual were found to be simi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42377-0
更新日期：1977-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of deep endometriosis (DE) on bladder function, focusing on detrusor pattern, in patients without preoperative urinary symptoms. DESIGN:Prospective study. SETTING:Academic research center. PATIENT(S):A total of 25 asymptomatic patients: 12 patients with DE (group 1) and 13 patients w...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.06.044
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To study the role of a synthetic insulin-like growth factor-I receptor (IGF-IR) antagonist, picropodophyllin, for mouse preimplantation embryo development in vivo and in vitro. DESIGN:In vitro and in vivo study. SETTING:Hospital-based research unit. ANIMALS:FVB/N mice and mouse embryos. INTERVENTION(S):Th...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.12.044
更新日期：2010-05-15 00:00:00
abstract：:Fifteen subfertile males with absent or atrophic right testes underwent ligation of left varicoceles. Sperm concentration rose significantly with correction of scrotal thermographic abnormality and nine wives (60%) became pregnant. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55098-5
更新日期：1992-06-01 00:00:00
abstract：:Embryo transfer is facilitated with ultrasound guidance. The 16 ultrasound-guided transfers were rated easier, and there was less catheter distortion, in comparison with 12 transfers guided by "clinical feel." The benefits we ascribe to ultrasound guidance are as follows: (1) transfers can be done with the patient sup...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48317-2
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of the second micro-testicular sperm extraction (TESE)in men with nonobstructive azoospermia in whom the first micro-TESE failed. DESIGN:Retrospective. SETTING:Private clinic. PATIENT(S):One hundred twenty-five men with nonobstructive azoospermia with failed previous micro-TESE. Th...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.10.005
更新日期：2020-12-23 00:00:00
abstract：OBJECTIVE:To measure serum anti-Müllerian hormone (AMH) during different phases of the menstrual cycle and to correlate the measurements with ovarian response and clinical-pregnancy rates in intracytoplasmic sperm injection cycles. DESIGN:Prospective cohort study. SETTING:University IVF unit. PATIENT(S):Thirty-three...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.05.040
更新日期：2008-06-01 00:00:00
abstract：:Two hundred ten treatment cycles of follicle-stimulating hormone (FSH) or human menopausal gonadotropin (hMG) were completed in 49 patients with clomiphene citrate-resistant polycystic ovarian syndrome. The results from 68 cycles of daily intramuscular (IM) FSH and 41 cycles of IM hMG were compared. The ovulation rate...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53511-0
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVES:To compare the results of IVF cycles after coasting in patients treated with a GnRH antagonist or GnRH agonist protocol. DESIGN:A retrospective case-control study. SETTING:Infertility unit in a university-affiliated tertiary medical center. PATIENT(S):The study group included all women less than 38 years ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.11.086
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To elucidate the LH receptor (LHR) expression patterns in human granulosa cells (GCs) from antral to preovulatory stages, and to investigate a correlation to oocyte function. DESIGN:Luteinized preovulatory GCs were obtained from preovulatory follicles aspirated during IVF (≥ 17 mm). The GCs from small- (<10 ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.12.027
更新日期：2012-03-01 00:00:00
abstract：:Seminiferous tubules from rats killed 24 hours after injection of pargyline, a monoamine oxidase inhibitor, did not grow well in tissue culture when compared to control tubules. Treated tubules showed severe tubular degeneration and loss of cellular detail after nine days in culture. Animals injected with pargyline fo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)40992-1
更新日期：1975-03-01 00:00:00
abstract：OBJECTIVE:To describe the use of Essure microinsert placement in patients with hydrosalpinges before IVF. DESIGN:Retrospective case-series. SETTING:An advanced endoscopic practice within a university-affiliated teaching hospital. PATIENT(S):Five women with unilateral or bilateral hydrosalpinges on transvaginal ultra...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.01.050
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:To assess the occult pregnancy rate after "negative" first post-embryo transfer (ET) serum β-hCG results. DESIGN:Two-part retrospective cohort study and nested case series. SETTING:University-based fertility center. PATIENT(S):A total of 1,571 negative first post-ET serum β-hCG results were included in the...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.11.049
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:To assess the potential association between polycystic ovary syndrome (PCOS) and chromosomally aberrant miscarriage during treatment with assisted reproductive technology (ART). DESIGN:A retrospective, single-center study. SETTING:University-affiliated reproductive center. PATIENT(S):A total of 328 patient...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.01.026
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:To review the available information regarding the polypeptide factors inhibin, activin, and follistatin in reproductive physiology. DESIGN:The protein structure, tissue expression, regulation, and effects of these factors are outlined, with an emphasis on the reproductive tissues in both females and males. A...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)58137-0
更新日期：1996-03-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the anti-P Org 31710 on human blastocyst attachment to cultured endometrial epithelial cells. DESIGN:Experimental in vitro study. SETTING:University hospital. PATIENT(S):Eleven fertile endometrial donors. INTERVENTION(S):Timed endometrial biopsy for cell cultures. MAIN OUTCOM...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.08.040
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To determine the regulatory role of hCG on P secretion in normal and abnormal (abortive and ectopic) first trimester pregnancies. STUDY DESIGN:The number of doublings of hCG per day (1/DT; reciprocal of hCG doubling time) was correlated with serum P using linear and nonlinear models in normal intrauterine pr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56876-9
更新日期：1994-08-01 00:00:00
abstract：:Since the dominant follicle is selected by days 5 to 7 of the menstrual cycle, we assessed the differential effects of high-dose clomiphene (25 mg daily) by giving 5-day courses either before (days 1 to 5), during (days 5 to 9), or after (days 9 to 13) emergence of the selected dominant follicle in monkeys. Peripheral...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46403-4
更新日期：1982-07-01 00:00:00
abstract：:Technical advances in massive parallel sequencing have allowed the characterization of the whole reproductive tract microbiome in all the compartments beyond the vagina. The microbiota in the uterine cavity seem to be a continuum from the microbiota in the vagina, but several works have reported significant difference...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2018.04.041
更新日期：2018-08-01 00:00:00
abstract：:Caffeine (1, 3, 7-trimethyl-2, 6-dioxypurine), a cyclic nucleotide phosphodiesterase inhibitor, increased the motility of ejaculated human spermatozoa. Both the percent motility and the grade of forward progression were significantly increased (P smaller than 0.001) and maintained in the presence of 6 mM of caffeine f...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)40936-2
更新日期：1975-02-01 00:00:00
abstract：OBJECTIVE:To determine the influence of ejaculatory abstinence on within-subject semen parameters and DNA fragmentation. DESIGN:Prospective study. SETTING:Private infertility institute and university-based research laboratory. PATIENT(S):Sixteen consenting male volunteers undergoing infertility investigation. INTER...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.03.014
更新日期：2004-07-01 00:00:00
abstract：:The first subsequent pregnancy rate in a group of women who accepted a variety of contraceptive methods after delivery and after therapeutic abortion is reviewed. Regardless of method chosen, 20 to 30% of postdelivery and 18 to 20% of postabortion patients were pregnant again after 1 year. In those patients who chose ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:To investigate hypoestrogenic "inactive phases" (IP) in the follicular phase of the menstrual cycle, with respect to age, reproductive stage, and follicular depletion. DESIGN:Analysis of prospectively collected menstrual bleed and estrone-3-glucuronide data. SETTING:Center for Population and Health, Georget...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.07.1101
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:To compare the ability of peripheral blood monocytes (PBM) and peritoneal macrophages (PM) to mediate the in vitro cytolysis of endometrial cells from eutopic and ectopic endometrium in women with endometriosis. DESIGN:Prospective study of immune function. SETTING:Institute for the Study and Treatment of En...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00062-4
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that plasma visfatin concentrations will be higher in women with polycystic ovary syndrome (PCOS) than in women without PCOS. DESIGN:Clinical study. SETTING:University hospital. PATIENT(S):A total of 52 women were evaluated. Twenty-six had PCOS, and the remaining 26 were healthy wome...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.11.120
更新日期：2007-08-01 00:00:00
