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High expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells is in correlation with decreased fertilization.

Abstract：

OBJECTIVE:To elucidate the LH receptor (LHR) expression patterns in human granulosa cells (GCs) from antral to preovulatory stages, and to investigate a correlation to oocyte function. DESIGN:Luteinized preovulatory GCs were obtained from preovulatory follicles aspirated during IVF (≥ 17 mm). The GCs from small- (<10 mm) and medium-sized (10-15 mm) follicles were obtained during in vitro maturation (IVM) procedures. Cumulus GCs were obtained during oocyte denudation for intracytoplasmatic sperm injection (ICSI) procedures (IVF). SETTING:Referral center. PATIENT(S):Seventy IVF patients and 20 IVM patients. INTERVENTION(S):GC collection. MAIN OUTCOME MEASURE(S):The LHR expression levels in mural and cumulus GCs of different follicular sizes and their correlation to oocyte outcome. RESULT(S):The LHR expression increased with follicle size and was higher in mural GCs compared with cumulus cells. The LHR expression in cumulus GCs from preovulatory follicles was higher in metaphase II (MII) oocytes than in metaphase I or germinal vesicle oocytes (IVF). Unexpectedly, higher expression of LHR in cumulus GCs of MII oocytes correlated with decreased fertilization rates. CONCLUSION(S):The LHR expression in small follicles obtained in IVM suggests a role for hCG administration during IVM procedures. Overexpression of LHR in cumulus GCs of MII oocytes may signal malfunction of oocytes and low fertilization capacity.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Maman E,Yung Y,Kedem A,Yerushalmi GM,Konopnicki S,Cohen B,Dor J,Hourvitz A

doi

10.1016/j.fertnstert.2011.12.027

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

592-8

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(11)02911-6

journal_volume

97

pub_type

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