Abstract：
OBJECTIVE:To evaluate serial hormone concentrations in subjects treated with vaginally administered misoprostol for early pregnancy failure. DESIGN:As part of a randomized clinical trial, serum was collected on treatment days 1, 3, 8, and 15. SETTING:Multicenter clinical trial. PATIENT(S):Women with a nonviable first-trimester pregnancy. INTERVENTION(S):Serum concentrations of human chorionic gonadotropin (hCG), progesterone, and sex hormone binding globulin (SHBG) were evaluated. MAIN OUTCOME MEASURE(S):A logistic regression model was constructed to assess the associations of percent and complete expulsion of the gestational sac and/or successful management. RESULT(S):The percent change from the day of treatment until the first follow-up visit was predictive for complete expulsion for progesterone (P) (P<.005) and hCG (P<.005), but not for SHBG. The actual value was not significantly associated with complete expulsion or successful management. A decrease (day 1-3) of 79% for both hCG and P was associated with a 90% probability of complete passage of the gestational sac. A 90% probability of successful management was noted if P decreased by 78% on day 3 or 59% on day 7, or hCG decreased by 74% on day 3 or 78% on day 7 compared with pretreatment values. CONCLUSION(S):Percent change, but not absolute change, in serial hormone values are strongly associated with both the complete expulsion of the gestational sac with one dose of misoprostol and ultimate success.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Barnhart KT,Bader T,Huang X,Frederick MM,Timbers KA,Zhang JJdoi
10.1016/j.fertnstert.2003.08.041keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
1099-105issue
4eissn
0015-0282issn
1556-5653pii
S0015028203030851journal_volume
81pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor alpha (PDGFR-alpha), and receptor beta (PDGFR-beta) between ute...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.02.031
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:To investigate whether immunological mechanisms may be involved in human luteal function. DESIGN:The effects of the cytokines, interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) on steroidogenesis by human luteal cells were examined in vitro. The dispersed ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：OBJECTIVE:To clarify the role and mechanism of CCL2 in regulating the biological functions of endometrial stromal cells (ESCs). DESIGN:The CCL2 effect on the viability, proliferation, and invasion in the eutopic ESCs from endometriosis. SETTING:Research laboratories. PATIENT(S):Patients with endometriosis aged 23-47...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.12.049
更新日期：2012-04-01 00:00:00
abstract：:Reducing exposure to toxic environmental agents is a critical area of intervention for obstetricians, gynecologists, and other reproductive health care professionals. Patient exposure to toxic environmental chemicals and other stressors is ubiquitous, and preconception and prenatal exposure to toxic environmental agen...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.08.043
更新日期：2013-10-01 00:00:00
abstract：:Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.11.032
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To compare the agonist flare-up and antagonist protocols in the management of poor responders to the standard long down-regulation protocol. DESIGN:Retrospective comparative study. SETTING:Assisted conception center. PATIENT(S):One hundred thirty-four patients undergoing IVF/ intracytoplasmic sperm injecti...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.07.963
更新日期：2005-02-01 00:00:00
abstract：:In an attempt to determine whether prolactin influences estrogen biosynthesis in the ovary, the estrogenic responses of women with amenorrhea under treatment with human menopausal gonadotropin (hMG), with and without the simultaneous administration of the prolactin inhibitor bromocriptine, were investigated in a total...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)44652-2
更新日期：1980-04-01 00:00:00
abstract：:An improved knowledge of cryopreservation of primate embryos will have important research and clinical application. Fifty-six 4- to 8-cell in vitro fertilized embryos were frozen in HEPES-buffered Tyrode's solution containing 1.5 M dimethylsulfoxide (DMSO) and cooled at the rate of 0.3 degrees C/minute to -39 degrees ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49225-3
更新日期：1986-03-01 00:00:00
abstract：OBJECTIVE:To compare outcome of pregnancies after intracytoplasmic sperm injection (ICSI) with those of other assisted reproductive technologies. DESIGN:Pregnancy outcomes after ICSI were followed prospectively and compared with pregnancy outcomes after IVF with fresh and frozen ETs and donor oocyte cycles. SETTING:A...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：OBJECTIVE:To report the transcervical and transisthmic evacuation of a dichorionic interstitial twin pregnancy guided by ultrasound. DESIGN:Case study. SETTING:Fetal medicine unit of university hospital. PATIENT(S):Dichorionic twin fetuses. INTERVENTION(S):Three-dimensional/four-dimensional (3D/4D) ultrasound-guide...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.07.1145
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. DESIGN:Prospec...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.09.019
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy of sperm disomy rate as a predictor of preimplantation genetic screening (PGT-A) outcomes. DESIGN:Retrospective cohort study. SETTING:Andrology laboratory and in vitro fertilization center. PATIENT(S):All patients (n = 123) who underwent sperm fluorescence in situ hybridization and P...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.02.004
更新日期：2020-06-01 00:00:00
abstract：:A patient with primary adrenocortical deficiency presented with galactorrhea and hyperprolactinemia, in addition to the usual characteristic symptoms of adrenal insufficiency. With steroid replacement therapy, PRL levels returned to normal, with resumption of normal ovulatory cycles; and the patient became pregnant. P...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48872-2
更新日期：1985-09-01 00:00:00
abstract：:Two women with the polycystic ovary syndrome were treated with bromocriptine (15 to 20 mg/day) in combination with spironolactone (100 mg/day). In the first woman the combined therapy induced a marked reduction of hirsutism, with ensuing ovulation and pregnancy. In the second woman, who had hyperthecosis and had been ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)45554-8
更新日期：1981-06-01 00:00:00
abstract：:This study was conducted to investigate the effects of unilateral cryptorchidism on androgen production and testicular maturation. Experimental cryptorchidism was produced in small and large prepuberal guinea pigs by forcing the testis to remain in the abdomen for a period of 30 days. Small prepuberal animals, which d...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1975-07-01 00:00:00
abstract：OBJECTIVE:To describe the prevalence of annexin V antibodies (aANX) in women with early recurrent pregnancy losses (RPLs) or recurrent IVF-ET failure. DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):Two hundred thirty-eight patients with RPLs, 48 patients with recur...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)02009-x
更新日期：2001-10-01 00:00:00
abstract：:Twenty-seven patients underwent ultrasonographic and clinical monitoring of a spontaneous cycle so that human chorionic gonadotropin administration could be timed in an attempt to schedule the screening laparoscopy at the optimal time for oocyte aspiration. Inadequate ovarian access was encountered in only 2 of 26 lap...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46871-8
更新日期：1983-03-01 00:00:00
abstract：OBJECTIVE:To evaluate whether microfluidic sperm sorters (MFSSs) allow effective recovery of sorted motile sperm without DNA damage compared with the centrifugation and swim-up procedure. DESIGN:Experimental laboratory study. All participants completed questionnaires regarding previous and/or current diseases, surgery...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.10.023
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To examine the influence of hormone-related factors on the risk of invasive epithelial ovarian cancer (ovarian cancer). DESIGN:Population-based case-control study using in-person interviews. SETTING:Academic department of preventive medicine. PATIENT(S):Four hundred seventy-seven ovarian cancer patients an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.03.013
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVES:To demonstrate the effectiveness of ultrarapid cryopreservation in human embryos. DESIGN:Retrospective study. SETTING:An IVF unit of a medical center. PATIENT(S):All cases received ultrarapid freezing (URF) of embryos and frozen embryo transfer. INTERVENTION(S):Embryos were placed in phosphate-buffered s...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00257-5
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:To survey the level of disclosure of conception method within families of children conceived by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and to examine the factors that might influence parental attitudes and plans for disclosure. DESIGN:In-depth questionnaire. SET...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.12.019
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the changes of pain symptoms induced by buserelin acetate, a gonadotropin-releasing hormone agonist, in a group of patients with endometriosis. DESIGN:Thirty-five infertile patients with one or more of the following symptoms (dysmenorrhea, pelvic pain, deep dyspareunia, and endometriosis stage I ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)55792-6
更新日期：1993-03-01 00:00:00
abstract：:Standardized, high-quality training in reproductive endocrinology, infertility, and assisted reproductive technologies (REI-ART) faces challenges owing to the high-tech nature of ART and the important country-to-country differences in clinical practice and regulations overseeing training. Moreover, while the training ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2015.04.031
更新日期：2015-07-01 00:00:00
abstract：:The hormonal profile of the aging male reveals an associated decrease in free testosterone and 5 alpha-dihydrotestosterone (DHT) levels and increased luteinizing hormone levels. Later events consist of a decrease in total testosterone, stable DHT, and increased follicle-stimulating hormone and estradiol levels. Althou...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41958-8
更新日期：1976-07-01 00:00:00
abstract：OBJECTIVE:To review existing scientific data related to the biology of estrogen in the aging process of women, and to understand the pharmacology, physiology, and diversity of sex hormones. DESIGN:A MEDLINE computer search was performed to identify relevant articles. RESULT(S):Estrogen and progesterone have been pres...
journal_title：Fertility and sterility
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.fertnstert.2003.10.052
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To investigate relationships between cumulus-oocyte complex (COC) morphology, protein patterns of cumulus-corona (CC) cell-conditioned media, and pregnancy outcome in IVF-ET cycles. DESIGN:Retrospective study. SETTING:Private university IVF center. PATIENT(S):One hundred twenty infertile women who underwen...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01754-x
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:To review published data and to compare pregnancy rates (PRs) after culturing human embryos with and without glucose and phosphate. DESIGN:Comparison of results from various programs. SETTING:Assisted Reproductive Technology Program. PATIENT(S):Patients were enrolled in various studies. INTERVENTION(S):Hu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00052-1
更新日期：1998-05-01 00:00:00
abstract：:Women with a BRCA mutation have unique concerns about childbearing and future fertility. In a focus group conducted among unaffected carriers, the majority of women held positive attitudes toward preimplantation genetic diagnosis to reduce transmission to future offspring and further identified unmet needs for educati...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.03.064
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) cycles. DESIGN:Prospective pilot study. SETTING:One university hospital and two private infertility clinics. PATIENT(S):Ninety-three infertile couples eligible for superov...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.02.070
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:To report a live birth after successful preimplantation genetic diagnosis (PGD) for carriers of complex chromosomal rearrangements (CCRs) with translocation and deletion. DESIGN:Fluorescent in situ hybridization (FISH) was applied to PGD for CCR carriers. SETTING:University-based centers for reproductive me...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.08.016
更新日期：2008-11-01 00:00:00
