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Comparison of the effect of oral and transdermal hormone therapy on fasting and postmethionine homocysteine levels.

Abstract：

OBJECTIVE:To compare the modifications on basal and post-methionine homocysteine (Hcy) levels induced by transdermal vs. oral continuous combined hormone therapy (HT). DESIGN:Prospective randomized study. SETTING:Outpatient service at university hospital. PATIENT(S):Twenty-four healthy postmenopausal women. INTERVENTION(S):Six-month administration of transdermal (50 microg/d of E(2) and 140-170 microg/d of norethisterone [NET] acetate; n = 12) or oral (2 mg of E(2) and 1 mg of NET acetate; n = 12) HT. MAIN OUTCOME MEASURE(S):Fasting levels of Hcy, cysteine (Cys), folate, and vitamin B12. Post-methionine Hcy concentrations. RESULT(S):During HT, a slight decrease of fasting Hcy (8.9 [6.7; 15.2] micromol/L vs. 8.3 [4.9; 12.0] micromol/L) and fasting Hcy/Cys, a possible index of Hcy trans-sulfuration (0.061 [0.039; 0.107] micromol/L vs. 0.048 [0.032; 0.093] micromol/L) was observed. Modifications were similar in the transdermal and oral group. Net decreases of Hcy and Hcy/Cys observed during HT were related linearly to pretreatment values (r = 0.821 and r = 0.775, respectively), and were significant for Hcy above, but not below, 9 micromol/L. Transdermal (33.5 [27.5; 75.9] micromol/L vs. 28.4 [17.4; 48.9] micromol/L) or oral HT (36.1 [17.7; 74.8] micromol/L vs. 29.9 [17.5; 50.3] micromol/L), decreased, similarly, post-methionine Hcy levels. CONCLUSION(S):Similarly to oral, transdermal HT reduces post-methionine Hcy and fasting Hcy when it is elevated.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Cagnacci A,Malmusi S,Zanni AL,Alessandrini C,Caretto S,Volpe A

doi

10.1016/j.fertnstert.2003.05.026

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

99-103

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015028203024543

journal_volume

81

pub_type

临床试验,杂志文章,随机对照试验

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