Abstract：
:The alkaloids ergocornine, vinblastine, and colcemide, with reported effects interfering with ovum implantation and development were investigated in the white New Zealand rabbit and the macaque monkey. 3 antimetabolites, 5-fluorouracil, 6-azauridine, and BW 57-323H, the 6 mercaptopurine derivative, were also investigated. Ergocornine was ineffective at the dosage employed (1.5-2.5 mg/kg) and vinblastine was teratogenic. Colcemide was administered in single doses ranging from .1-5 mg/kg. From Day 9 until term it was an extremely toxic agent to the developing fetus, death occurring within 2-4 hours after administration. At 5.0 mg/kg, 50% of the animals died from toxicity. Administration in the macaque monkey on Days 24, 45, 66, and 84 of pregnancy was without effect. 2-antimetabolites tested in the rabbit (5-fluorouracil and 6-azauridine) had little effect. BW 57-323H administered interperitoneally to pregnant rabbits resulted in complete litter destruction early in pregnancy, was teratogenic midpregnancy and ineffective in late pregnancy. This compound was without effect in macaques when administered on Days 28-30.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Morris JM,Van Wagenen G,Hurteau GD,Johnston DW,Carlsen RAdoi
10.1016/s0015-0282(16)36181-7subject
Has Abstractpub_date
1967-01-01 00:00:00pages
7-17issue
1eissn
0015-0282issn
1556-5653pii
S0015-0282(16)36181-7journal_volume
18pub_type
杂志文章abstract：:Women who exercise heavily may develop secondary amenorrhea. Since the mechanism of so-called "runner's amenorrhea" has not been conclusively established, the authors examined the occurrence of amenorrhea in one of the most intensively exercising groups of female runners in the United States (average, 70 miles/week): ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:Mild-stimulation protocols with in vitro fertilization (IVF) generally aim to use less medication than conventional IVF. This guideline evaluates pregnancy and live-birth rates in patients expected to be poor responders using mild ovarian stimulation and natural-cycle protocols vs conventional IVF. ...
journal_title：Fertility and sterility
pub_type： 杂志文章,实务指引
doi：10.1016/j.fertnstert.2018.03.019
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To determine the genetic cause of primary amenorrhea. DESIGN:Case series. SETTING:Pediatric endocrinology, endocrinology, and gynecology departments of academic hospitals. PATIENT(S):Three adolescents and one young woman 46, XY patients with srd5A2 gene mutations. MAIN OUTCOME MEASURE(S):Genetic analysis ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.08.007
更新日期：2011-02-01 00:00:00
abstract：:Ten infertile women 20 to 40 years of age, with a standard HSG diagnosis of unilateral proximal tubal obstruction, underwent a transvaginal catheterization and recanalization of the fallopian tubes. To set a fluoroscopic real-time guidance technique for improving the results of transvaginal catheterization and recanal...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55344-8
更新日期：1992-10-01 00:00:00
abstract：:No nerve fibers are found in endometriomas or in the endometrioma-containing ovaries. These findings are consistent with our previous report that no correlation exists between the presence of nerve fibers and endometriosis. ...
journal_title：Fertility and sterility
pub_type： 信件
doi：10.1016/j.fertnstert.2003.11.049
更新日期：2004-07-01 00:00:00
abstract：:In the present study, we measured urinary hCG after assisted reproductive technology to accurately calculate normal doubling time (DT) of hCG, and we compared DT values with prognosis of pregnancy. We clarified the correlation between normal DT values, calculated from urinary hCG levels, and viable and nonviable pregn...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.03.066
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of dienogest on the expression of Toll-like receptor (TLR) 4 in human endometrial epithelial cells. DESIGN:Prospective basic research study. SETTING:Pharmaceutical research center. PATIENT(S):None. INTERVENTION(S):Not applicable. MAIN OUTCOME MEASURE(S):TLR4 in the immortalized ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.09.040
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To review the definition and diagnosis of interstitial and heterotopic interstitial pregnancy and to evaluate the conservative management of these conditions. DESIGN:A MEDLINE computer search was used to identify relevant studies. The mean values for the duration of amenorrhea, serum beta-hCG level, size of ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(99)00242-3
更新日期：1999-08-01 00:00:00
abstract：:A detailed study was initiated to investigate thoroughly the possibility that any significant ophthalmologic changes might have occurred in patients using oral contraceptives (OCs) for varying periods. There were 212 patients and 50 control patients who were selected at random, 1/2 from private ophthalmology practice...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)35820-4
更新日期：1966-01-01 00:00:00
abstract：OBJECTIVE:To study the fusiogenic ability of human spermatozoa and oocytes. DESIGN:Retrospective study of 3,027 oocytes included in a program of subzonal insemination (SUZI). SETTING:Assisted fertilization program in an academic research environment. PATIENT(S):Couples with characterized male factor infertility or p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81445-8
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of vascular endothelial growth factor (VEGF) injection into the testes on spermatogenesis and apoptosis in a varicocele-induced adolescent rat model. SETTING:University hospital urology research laboratory. ANIMAL(S):Six-week-old male Wistar rats (n = 32). INTERVENTION:The rats we...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.06.008
更新日期：2009-05-01 00:00:00
abstract：:This study fails to uphold the concept of invisible, microscopic endometriosis. Peritoneum devoid of disease exists, can be described, and can be consistently found. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60205-4
更新日期：1988-10-01 00:00:00
abstract：:The potential role of Ureaplasma urealyticum in human infertility make it desirable to screen barren couples for this infection. Semen specimens from 96 consecutive patients were evaluated in our clinic. Microbiologic results were correlated with the percentage of coiled and fuzzy tails in seminal cytology. These feat...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：
更新日期：1978-11-01 00:00:00
abstract：OBJECTIVE:To review osteoporosis, a disease characterized by low bone mass, microarchitectural deterioration of bone tissue leading to increased bone fragility and a consequent increase in fracture risk. The disorder has become a major health problem in the West, where increased life expectancy has placed new emphasis ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：
更新日期：1994-12-01 00:00:00
abstract：:Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48020-9
更新日期：1984-08-01 00:00:00
abstract：OBJECTIVE:To evaluate follicular FSH and LH requirements during suppression of endogenous gonadotropins with the GnRH antagonist Nal-Glu and whether LH-like activity could be supplied by administering subcutaneous hCG. DESIGN:Randomized clinical trial. PARTICIPANTS:Thirty-two normally cycling females in the late foll...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:To summarize the procedures and outcomes of assisted reproductive technology (ART) initiated in the United States in 1997. DESIGN:Data were collected electronically by using Society for Assisted Reproductive Technology Clinical Outcome Reporting System software and were submitted to the American Society for ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(00)01559-4
更新日期：2000-10-01 00:00:00
abstract：:Midluteal phase corpora lutea (CL) obtained from women induced with 50 mg (n = 5), 100 mg (n = 5), and 150 mg (n = 5) of clomiphene citrate (CC) were measured for luteinizing hormone/human chorionic gonadotropin (LH/hCG) concentrations and cytosol progesterone (P) and 17 alpha-hydroxyprogesterone (17-OHP) and compared...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:In a program of human in vitro fertilization (IVF), the results of 204 attempted intracervical embryo transfers (ETs), using a variety of catheters in three trials over 18 months, have been analyzed for the ease of transfer and pregnancy rate. In nulliparous patients, transfers were more difficult than in multiparous ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46451-4
更新日期：1982-08-01 00:00:00
abstract：:Surgical ablation of the inferior mesenteric plexus in the rat results in an excessive accumulation of sperm within the cauda epididymidis. The present study examined the effect of ablation of the inferior mesenteric plexus on the motility of cauda epididymal spermatozoa. One to 8 weeks after ablation of the inferior ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVE:To investigate whether zona drilling of oocytes, a technique used to locally disrupt the zona pellucida, causes important changes in intracellular pH. DESIGN AND METHODS:In a first set of experiments, intracellular pH was measured during zona drilling of mouse oocytes, using pH-sensitive microelectrodes. In ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56525-x
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:To investigate relations between dose of GnRH antagonist and follicular phase characteristics. DESIGN:Randomized controlled multicenter trial. SETTING:Tertiary referral fertility centers. PATIENT(S):Three hundred and twenty-nine IVF patients. INTERVENTION(S):Ovarian stimulation for IVF with recombinant FS...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(00)01789-1
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between follicular and serum nitric oxide (NO) levels and embryo development and outcome in IVF. DESIGN:Prospective, case-control study. SETTING:University hospital, tertiary medical center. PATIENT(S):Eighteen patients with tubal or peritoneal factor infertility and 18 female p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.02.097
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To examine the reproductive outcome after operative hysteroscopic resection of submucous myomas in women for whom no other infertility factor was identified. DESIGN:Fifteen infertile women with submucous myomas underwent an intensive workup to exclude other causes of infertility. Operative hysteroscopy for r...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57844-3
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVE:To evaluate serum inhibin B as a predictor of poor ovarian response in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) and to compare it with the performance of antimüllerian hormone (AMH). DESIGN:Meta-analysis. SETTING:University hospital. PATIENT(S):Patients undergo...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析
doi：10.1016/j.fertnstert.2011.07.1102
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:To analyze the role of the local renin-angiotensin system (RAS) in the female reproductive system to modulate ovarian steroidogenesis and its relationship with alpha(1)adrenergic receptors. DESIGN:Observational study. SETTING:University laboratory. ANIMAL(S):Adult female Wistar rats treated with doxazosin ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.021
更新日期：2007-10-01 00:00:00
abstract：:Effects of single subcutaneous doses (1, 5, 20, and 100 micrograms) of nafarelin, a potent gonadotropin-releasing hormone agonist, on the physiologic events of the human menstrual cycle were studied in 28 normal women. Nafarelin entered the circulation rapidly after injection. Peak concentrations were observed within ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48432-3
更新日期：1985-03-01 00:00:00
abstract：:A new sperm isolation technique was studied in conjunction with the short-term freeze preservation of human spermatozoa. The isolation procedure yielded subpopulations of spermatozoa with very high percentage motility and progressive motility score, and which were virtually free of seminal debris. For 24 semen samples...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42196-5
更新日期：1976-11-01 00:00:00
abstract：:Fifteen subfertile males with absent or atrophic right testes underwent ligation of left varicoceles. Sperm concentration rose significantly with correction of scrotal thermographic abnormality and nine wives (60%) became pregnant. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55098-5
更新日期：1992-06-01 00:00:00
abstract：:We studied 68 men with varicoceles to determine preoperative parameters that are associated with improvements in semen analysis after varicocelectomy. Ultrasound-measured venous diameter and reversal of flow were found to correlate with successful outcome. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.12.038
更新日期：2006-07-01 00:00:00
