Abstract：
OBJECTIVE:To evaluate the effects of the immunosuppressant tacrolimus on rejection of a transplanted uterus and on uterine expression of markers of inflammation and implantation. DESIGN:Experimental study. SETTING:University laboratory. ANIMAL(S):Female rats. INTERVENTION(S):Uteri from brown Norway rats were transplanted to Lewis rats, receiving either tacrolimus or no treatment. Sham groups underwent either hemihysterectomy or tacrolimus treatment. MAIN OUTCOME MEASURE(S):Gross morphology, histology, density of T-lymphocytes by immunohistochemistry, and mRNA levels of interleukin (IL)-1α, leukemia inhibitory factor (LIF), galectin-1, CD200, IL-15, interferon-inducible protein-10 (IP-10), and nuclear factor-κB (NF-κB) at 14 days' post-transplantation. RESULT(S):Nontreated uterine grafts showed rejection with necrosis. Sham groups and the tacrolimus-treated transplanted group exhibited normal uterine morphology with low numbers of T-lymphocytes in all uteri except in two out of seven uteri of the tacrolimus-treated transplant group. Uteri of the nontreated transplanted group showed elevated mRNA expression of IL-1α and IP-10 and reduced galectin-1, compared with the tacrolimus-treated transplanted group. There was no difference between any groups concerning uterine expression of LIF, NF-κB, IL-15, and CD200. CONCLUSION(S):Tacrolimus monotherapy suppresses rejection of an allotransplanted uterus and normalizes the expression of IL-1α and IP-10 and prevents T-lymphocyte infiltration.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Akhi SN,Diaz-Garcia C,El-Akouri RR,Wranning CA,Mölne J,Brännström Mdoi
10.1016/j.fertnstert.2012.11.002subject
Has Abstractpub_date
2013-03-01 00:00:00pages
862-70issue
3eissn
0015-0282issn
1556-5653pii
S0015-0282(12)02395-3journal_volume
99pub_type
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journal_title：Fertility and sterility
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abstract：OBJECTIVE:To describe a woman with a nonmosaic (45,X) form of Turner's syndrome who gave birth to a girl with 45,X Turner syndrome. DESIGN:Patient report. SETTING:Outpatient clinic of a university hospital. PATIENT(S):A woman with typical phenotypic features of Turner syndrome and a 45,X karyotype and her daughter w...
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更新日期：2004-10-01 00:00:00
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journal_title：Fertility and sterility
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更新日期：2004-06-01 00:00:00
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journal_title：Fertility and sterility
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journal_title：Fertility and sterility
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更新日期：2006-07-01 00:00:00
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更新日期：2006-02-01 00:00:00
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更新日期：2010-11-01 00:00:00
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