Abstract：
OBJECTIVE:To evaluate the effectiveness of growth hormone (GH) supplementation in improving the in vitro fertilization (IVF) outcomes of poor responders. DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENT(S):Poor ovarian responders undergoing conventional IVF or intracytoplasmic sperm injection (ICSI). INTERVENTION(S):Randomized controlled trials (RCTs) of poor ovarian responders undergoing a single IVF/ICSI cycle with GH supplementation versus conventional controlled ovarian stimulation. This review was registered in the PROSPERO database before starting data extraction (CRD42020151681). MAIN OUTCOME MEASURE(S):Primary outcome was live birth rate. Clinical pregnancy rate, miscarriage rate, ongoing pregnancy rate, number of oocytes, number of mature (metaphase II [MII]) oocytes and the number of embryos available to transfer were considered as secondary outcomes. RESULT(S):Twelve RCTs were included; 586 women were assigned to the intervention group and 553 to the control group. The analysis revealed that patients receiving GH supplementation did not show an increased live birth rate, miscarriage rate, or ongoing pregnancy rate. However, GH supplementation in poor responders increased clinical pregnancy rate, number of oocytes retrieved (mean difference 1.62), number of MII oocytes (mean difference 2.06), and number of embryos available to transfer (mean difference 0.76). Sensitivity and subgroup analyses did not provide statistical changes to pooled results. CONCLUSION(S):The present meta-analysis provides evidence that GH supplementation may improve some reproductive outcomes in poor responders, but not live birth rates.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Cozzolino M,Cecchino GN,Troiano G,Romanelli Cdoi
10.1016/j.fertnstert.2020.03.007subject
Has Abstractpub_date
2020-07-01 00:00:00pages
97-109issue
1eissn
0015-0282issn
1556-5653pii
S0015-0282(20)30252-1journal_volume
114pub_type
杂志文章abstract：:In this Views and Reviews section, the authors present the most updated information on menopausal hormone therapy (MHT) and an individualized treatment approach. Care of women through the menopausal transition and post-menopausally requires physicians to integrate multi-organ implications of MHT and understand the ful...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2014.02.026
更新日期：2014-04-01 00:00:00
abstract：:Forty-four women were prospectively evaluated with a 3-hour oral glucose tolerance test while they used a new weekly oral contraceptive drug, R2323. The blood tests were carried out before the drug was administered and again 3 months after its use. Both blood glucose and plasma insulin levels were measured. In the 40 ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)43513-2
更新日期：1978-09-01 00:00:00
abstract：OBJECTIVE:Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy ovarian function. DE...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2007.02.022
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Since little is known about the actual incidence and fate of vacuoles at different stages of development this preliminary study was set up to accurately measure vacuoles and track them to day 5. DESIGN:Prospective study. SETTING:Women's General Hospital in Austria. PATIENT(S):A total of 223 consecutive IVF...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.02.009
更新日期：2005-06-01 00:00:00
abstract：:The basal body temperature (BBT) charts in pregnancy cycles of 110 consecutive women who became pregnant by a single heterologous insemination were studied. The occurrence of ovulation was proved by the pregnancies in each case. All of these pregnancy charts showed a biphasic pattern, and most followed one of three st...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46577-5
更新日期：1982-10-01 00:00:00
abstract：:Forty-four cycles with a spontaneous luteinizing hormone (LH) surge among 377 in vitro fertilization (IVF) patients were studied for outcome with different timing of oocyte retrieval. Mean number of preovulatory oocytes per retrieval and per transfer was significantly less in these cycles than in controls. Mean number...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60131-0
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVE:To correlate the diagnosis of endometriosis in lesions excised at laparoscopy with pathologic diagnosis. DESIGN:Prospective study. SETTING:U.S. government research hospital. PATIENT(S):Women with chronic pelvic pain thought to be due to endometriosis. INTERVENTION(S):Excision of lesions suspicious for end...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03337-x
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:To study the oocyte quality in patients with ovarian hyperstimulation syndrome (OHSS). DESIGN:Retrospective study. SETTING:The Egyptian IVF-ET Center. PATIENT(S):Forty-two patients who developed severe OHSS (group A) were studied for the mean number of oocytes retrieved, percentage of high-quality oocytes,...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00409-3
更新日期：1997-12-01 00:00:00
abstract：:Many women now choose to develop their careers before having children. Thus, it is becoming increasingly important to assess a woman's potential for extended fertility and to understand the health consequences of having children at a late age. In particular, there is a striking positive correlation between extended fe...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2015.02.008
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:To determine whether antisperm autoantibody production after prepubertal vas injury is influenced by immediate repair of the vas compared to delay of the reanastomosis until sexual maturity. DESIGN:Animal study comparing early repair, late repair, and sham-operated groups. SETTING:Research laboratory in a m...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00501-4
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:To evaluate whether intrauterine injection of hCG before embryo transfer can improve IVF-ET outcomes. DESIGN:Meta-analysis. SETTING:Not applicable. PATIENT(S):Infertile women who underwent IVF-ET and received an intrauterine injection of hCG before ET. INTERVENTION(S):Infertile women treated with or witho...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.fertnstert.2019.02.027
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:To develop a consensus regarding the need for luteal phase support during assisted reproductive technology (ART), and to establish the optimal compound and route of administration for this purpose. DESIGN:Review of the published literature on luteal phase support. PATIENT(S):Women undergoing assisted reprod...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(01)02961-2
更新日期：2002-02-01 00:00:00
abstract：:Significant advances have been made in our understanding of ovarian dysfunction in polycystic ovary syndrome (PCOS), and alterations in adipose tissue function are likely to play an important role in its pathophysiology. This review highlights the principal novel concepts presented at the 4th special scientific meetin...
journal_title：Fertility and sterility
pub_type： 共识发展会议,杂志文章,评审
doi：10.1016/j.fertnstert.2009.03.058
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the incidence of monozygotic twinning (MZT) in pregnancies conceived after blastocyst transfer compared to cleavage-stage transfer. DESIGN:Retrospective study. SETTING:University IVF program. PATIENT(S):All IVF patients with viable pregnancies conceived during a 4-year period. INTERVENTION(S):...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04754-4
更新日期：2003-03-01 00:00:00
abstract：:A number of patients who have involuntary infertility show sperm antibodies in the blood serum, as detected by two quite different methods of spermagglutination. These techniques are the Kibrick method (gelatin agglutination test) and the F-D method (tube-slide agglutination test). By the former technique, the sera of...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)43158-4
更新日期：1978-03-01 00:00:00
abstract：OBJECTIVE:To determine whether mutations in the gene for FSH beta are present, and possibly etiologic, in some patients with 46,XX premature ovarian failure (POF). DESIGN:DNA samples obtained from 18 study patients with POF and two menopausal fertile controls were studied by Southern blot analysis. DNA sequencing was ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56286-4
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:To investigate the localization of tenascin expression in the endometrium of women without endometriosis and in endometriotic implants, and to determine the in vitro regulation of tenascin by E(2) in these tissues. DESIGN:Experimental laboratory study. SETTING:University medical center. PATIENT(S):Reproduc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.05.028
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To evaluate serum inhibin B as a predictor of poor ovarian response in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) and to compare it with the performance of antimüllerian hormone (AMH). DESIGN:Meta-analysis. SETTING:University hospital. PATIENT(S):Patients undergo...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析
doi：10.1016/j.fertnstert.2011.07.1102
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:To examine the relation between uterine blood flow and endometrial thickness on transvaginal Doppler ultrasonography, serum E2 and progesterone levels, and the histologic dating of an endometrial biopsy specimen obtained in the midluteal phase of a spontaneous cycle. DESIGN:Prospective clinical study. SETTI...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00455-0
更新日期：2000-01-01 00:00:00
abstract：:Semen specimens were obtained for analysis from nine men immediately before vasectomy and 3 days following the vasectomy procedure. After vasectomy there was a significant decrease in seminal sperm concentration, percentage of sperm motility, and mean swimming speed. In seven of nine cases the spermatozoa did not surv...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48262-2
更新日期：1984-12-01 00:00:00
abstract：OBJECTIVE:To report the use of cumulative live-birth rates (CLBRs) per ovarian stimulation cycle to measure the success of IVF is proving to be the most accurate method for advising couples who failed to conceive, although the accuracy yielded is relatively low, and cycle outcome is highly dependent on the number of em...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.05.008
更新日期：2011-07-01 00:00:00
abstract：:The effect of six metabolically active compounds, namely caffeine, kallikrein, cyclic adenosine 3':5'-monophosphate, prostaglandin E, triiodothyronine, and insulin on spermatozoal motility was investigated. Hypokinetic and normokinetic semen specimens from fertile and infertile patients were incubated with various con...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：OBJECTIVE:To assess the effects of estro-progestin supplementation on ghrelin-mediated GH release, we studied the consequence of ghrelin or saline injection before and after 60 days of hormone therapy or placebo administration in postmenopausal subjects. DESIGN:A prospective double blind, placebo-controlled, and paral...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2007.02.042
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of curcumin on aflatoxin-induced biochemical changes in testis of mice. DESIGN:Controlled research laboratory study. SETTING:Aflatoxin was obtained by growing Aspergillus parasiticus in SMKY liquid medium. Pure curcumin (97% purity) was purchased from Hi-Media Laboratories Pvt. Ltd...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.11.053
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To test the effects of steroid-containing media such as follicular fluid (FF) and serum and of steroid-free but human protein-rich medium on hyperactivation (HA) of human spermatozoa with and without a preincubation period. DESIGN:Analysis of HA using a computer-aided sperm analysis system. SETTING:Academic...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57191-x
更新日期：1994-12-01 00:00:00
abstract：:Three groups of dogs underwent testicular ischemia for a 3-hour period. Group I (10 animals) was not subsequently perfused. Group II (10 animals) underwent subsequent perfusion by a new in vivo reversible method via the internal spermatic artery with heparinized saline. Group III (5 animals) underwent perfusion with S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42924-9
更新日期：1977-11-01 00:00:00
abstract：OBJECTIVE:To investigate relationships between cumulus-oocyte complex (COC) morphology, protein patterns of cumulus-corona (CC) cell-conditioned media, and pregnancy outcome in IVF-ET cycles. DESIGN:Retrospective study. SETTING:Private university IVF center. PATIENT(S):One hundred twenty infertile women who underwen...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01754-x
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:We previously demonstrated that adherence of endometrial epithelial (EECs) and stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) is partly regulated by ESC/EEC CD44 interactions with PMC associated hyaluronan. CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice va...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.12.012
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:To evaluate whether the developmental potential of the blastocyst is affected by the number of trophectoderm (TE) cells biopsied in preimplantation genetic diagnosis (PGD) cycles. DESIGN:Retrospective study. SETTING:University-affiliated center. PATIENT(S):Women underwent PGD cycles of blastocyst biopsy an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.01.011
更新日期：2016-05-01 00:00:00
abstract：:Rhesus monkeys develop agglutinating and complement-dependent antisperm antibodies after vasectomy. In order to study whether these antibodies affect fertility after vasovasostomy, 15 animals were given vasectomies and 6 months later vasovasostomies. Subsequently, each was mated with females of proven fertility. Five ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1977-05-01 00:00:00
