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Higher aneuploidy rates of chromosomes 13, 16, and 21 in a patient with globozoospermia.

Abstract：

OBJECTIVE:To analyze rates of chromosomal anomalies in a patient with globozoospermia. DESIGN:Case report. SETTING:Tertiary-care infertility clinic. PATIENT(S):A 44-year-old man with 100% globozoospermia. INTERVENTION(S):Fixation of sperms and analysis of aneuploidies and diploidies by fluorescence in situ hybridization. MAIN OUTCOME MEASURE(S):Aneuploidy rates of chromosomes 13, 16, and 21 and diploidy rate in a patient with 100% globozoospermia. RESULT(S):The aneuploidy rates in spermatozoa from a patient with globozoospermia were significantly higher than in a normospermic man. The incidence of a disomy of the chromosomes 13, 16, and 21 was 4%, 5%, and 1%, respectively, and the nullisomy rates were 2%, 2%, and 3%, respectively. CONCLUSION(S):This study demonstrates a positive correlation between globozoospermia and higher chromosomal aneuploidies of the chromosomes 13, 16, and 21, suggesting a higher risk of creating aneuploid embryos after intracytoplasmic sperm injection treatment for globozoospermia patients.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Ditzel N,El-Danasouri I,Just W,Sterzik K

doi

10.1016/j.fertnstert.2005.01.109

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

217-8

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(05)00587-X

journal_volume

84

pub_type

杂志文章

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