Treatment of endometriosis with the antiprogesterone mifepristone (RU486)

Abstract:

OBJECTIVE:To evaluate the safety and efficacy of an antiprogesterone (mifepristone, RU486; Roussel-Uclaf, Romaineville, France) on endometriosis. DESIGN:An open, prospective clinical trial. SETTING:The clinical practice of an academic faculty. PATIENTS:Nine women with endometriosis were studied. INTERVENTIONS:RU486 (50 mg/d) was administered for 6 months. MAIN OUTCOME MEASURES:Daily symptom inventories and urinary steroid metabolites were assessed before, during, and after treatment. Blood for hormone analysis was obtained weekly for 4 weeks and monthly thereafter. The extent of endometriosis, bone mineral density, circadian rhythm of cortisol, and LH pulsatility were determined before and after treatment. Safety laboratory measurements were made before and at 1, 2, and 6 months of treatment. RESULTS:Pelvic pain and uterine cramping improved in all patients. Endometriosis regressed by 55%. All patients exhibited endocrine features of anovulatory amenorrhea without hypoestrogenism. A rise in serum LH and T levels was observed during the first month of treatment and one patient developed an elevation of liver transaminases during the last month of treatment. All other measurements were unchanged. CONCLUSION:RU486 appears to be effective in improving the symptoms and causing regression of endometriosis in the absence of significant side effects.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kettel LM,Murphy AA,Morales AJ,Ulmann A,Baulieu EE,Yen SS

doi

10.1016/s0015-0282(16)58022-4

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

23-8

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)58022-4

journal_volume

65

pub_type

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