Evaluation of interceed(TC7) for reduction of postoperative adhesions in rabbits.

Abstract:

OBJECTIVE:To evaluate the effectiveness of Interceed(TC7) (Johnson and Johnson, New Brunswick, NJ) in the prevention of postoperative adhesions in a rabbit uterine horn model. Interceed(TC7) was tested in the presence and absence of absorbable suture. DESIGN, SETTING, PARTICIPANTS:Forty-one New Zealand white rabbits had lesions created on bilateral uterine horns at laparotomy. Lesions were randomly allocated to treatment with Interceed(TC7) or control. The effect of Interceed(TC7) was evaluated on sutured lesions (4-0 polyglactin 910; Ethicon, Inc., Somerville, NJ) as well as on open cut lesions (no sutures applied). MAIN OUTCOME MEASURES:Adhesion formation, using a grading system ranging from 0 to 3. RESULTS:Interceed(TC7)-treated animals in the sutured group (average adhesion score +/- SD = 2.15 +/- 1.3) did not differ from controls (average score +/- SD = 2.35 +/- 0.93) in adhesion formation, P = 0.47. Rabbits with open cut lesions treated with Interceed(TC7) (average adhesion score +/- SD = 1.89 +/- 1.1) did not differ from control animals (average score +/- SD = 1.83 +/- 1.2), P = 0.88. CONCLUSIONS:Interceed(TC7) was not an effective adhesioprophylactic agent in the presence or absence of nonreactive absorbable suture.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Best CL,Rittenhouse D,Vasquez C,Norng T,Subias E,Sueldo CE

keywords:

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

817-20

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)55333-3

journal_volume

58

pub_type

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