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High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders.

Abstract：

OBJECTIVE:To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. DESIGN:Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. SETTING:Academic tertiary center. PATIENTS:A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined. INTERVENTIONS:All patients were stimulated using a combination of a GnRH-agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules). MAIN OUTCOME MEASURES:Implantation and pregnancy (clinical and ongoing) rates were compared. RESULTS:There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates. CONCLUSIONS:We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Simon T,Oehninger S,Toner J,Jones D,Muasher S

doi

10.1016/s0015-0282(16)57621-3

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

1333-6

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)57621-3

journal_volume

63

pub_type

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