Tamoxifen treatment in male infertility. I. Effect on spermatozoa.

Abstract:

OBJECTIVE:To evaluate the effects of tamoxifen treatment on sperm density, motility, vitality, and morphology. DESIGN:Placebo-controlled, randomized study. SETTING:Outpatient department. INTERVENTIONS:Patients were assigned to two comparable groups: group A (n = 122) was treated with 10 mg tamoxifen twice daily for a period of 3 months and group B (n = 117) was given placebo for the same period of time, following a previously randomized design. MAIN OUTCOME MEASURES:In every patient sperm density, motility, viability, and morphology were evaluated 3 months after cessation of treatment. RESULTS:Mean sperm density in group A improved significantly with a more pronounced improvement in severe oligozoospermic men. Sperm density was found significantly improved compared with group B. Dead spermatozoa in group A significantly decreased after tamoxifen treatment and were also found significantly decreased compared with group B. CONCLUSION:It is concluded that tamoxifen exerts a beneficial effect on sperm density and number of live spermatozoa but it has no substantial effect in sperm motility and morphology.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kotoulas IG,Cardamakis E,Michopoulos J,Mitropoulos D,Dounis A

doi

10.1016/s0015-0282(16)56705-3

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

911-4

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)56705-3

journal_volume

61

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:OBJECTIVE:To evaluate endometrial adhesion and invasion of peritoneal mesothelium. DESIGN:Descriptive study using confocal laser-scanning microscopy. SETTING:University-based laboratory. PATIENT(S):Women undergoing surgery for benign conditions. INTERVENTION(S):Fluorescence-labeled peritoneal mesothelial cells (PMC...

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    authors: Witz CA,Cho S,Centonze VE,Montoya-Rodriguez IA,Schenken RS

    更新日期:2003-03-01 00:00:00

  • Antisperm antibodies and fertility after vasovasostomy: a follow-up study of 216 men.

    abstract::A group of 216 vasovasostomized men were tested with the mixed antiglobulin reaction for immunoglobulin (Ig)G, IgA, and secretory IgA antisperm antibodies bound to the sperm membrane. Free antisperm antibodies in serum and seminal plasma were detected with the gelatin agglutination test and the tray agglutination test...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:

    authors: Meinertz H,Linnet L,Fogh-Andersen P,Hjort T

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  • Fraction of the peripheral blood concentration of CD56+/CD16-/CD3- cells in total natural killer cells as an indication of fertility and infertility.

    abstract:OBJECTIVE:To determine whether the peripheral blood concentration of CD56(+)/CD16(-)/CD3(-) cells, the main natural killer (NK) subpopulation that colonizes the endometrium in the middle and late secretory phase, can be related to fertility or infertility status. DESIGN:A case control study. SETTING:Immunopathology d...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    authors: Michou VI,Kanavaros P,Athanassiou V,Chronis GB,Stabamas S,Tsilivakos V

    更新日期:2003-09-01 00:00:00

  • Tumor necrosis factor-alpha regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts.

    abstract::Tumor necrosis factor-alpha stimulates the secretion of vascular endothelial growth factor by cultured human oviductal epithelial cells and stromal fibroblasts. Tumor necrosis factor-alpha-stimulated vascular endothelial growth factor secretion by these cells may control oviductal fluid secretion by regulating vascula...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.05.082

    authors: Nasu K,Itoh H,Yuge A,Nishida M,Kawano Y,Narahara H

    更新日期:2007-01-01 00:00:00

  • Maturation and apoptosis of human oocytes in vitro are age-related.

    abstract:OBJECTIVE:To study the morphological changes of apoptotic oocytes, and rates of in vitro maturation and apoptosis of human oocytes in relation to age. DESIGN:Prospective comparative study. SETTING:Reproductive medicine center. PATIENT(S):Women undergoing surgery for ovarian cysts. INTERVENTION(S):Oocytes were incub...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(00)01597-1

    authors: Wu J,Zhang L,Wang X

    更新日期:2000-12-01 00:00:00

  • Effect of paramethasone acetate upon estrogen action.

    abstract::To test the antiestrogenic action of paramethasone acetate (PA), a group of five postmenopausal women were treated in two ways. For phase I, PA + mestranol, 6 mg + 80 micrograms per day for 10 days, was administered. Ten days were allowed for withdrawal of medication. For phase II, mestranol, 80 micrograms per day for...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:

    authors: Cortés-Gallegos V,Carranco A,Sojo I,Alonso R,Valenzuela-Duriet P

    更新日期:1982-03-01 00:00:00

  • Ultrastructural sperm tail defects associated with sperm immotility.

    abstract::Four individuals with a complaint of infertility were evaluated after a semen analysis had demonstrated no motility. The semen analyses were otherwise normal, with the exception of a low count in one subject. All had normal percentages of living sperm. One of the individuals had chronic respiratory disease, and two ot...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)47549-7

    authors: Williamson RA,Koehler JK,Smith WD,Stenchever MA

    更新日期:1984-01-01 00:00:00

  • Compound genetic abnormalities in patients with cystic fibrosis transmembrane regulator gene mutation.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.07.1537

    authors: Karpman E,Williams DH 4th,Wilberforce S,Lipshultz LI

    更新日期:2007-06-01 00:00:00

  • Anaphylactic reaction to synthetic luteinizing hormone-releasing hormone.

    abstract::Synthetic LH-RH is a polypeptide that is structurally identical to natural LH-RH. It has been used as a safe ovulation induction agent. A case is presented in which a patient had an anaphylactic reaction when treated with LH-RH by IV infusion. Positive skin testing confirmed this as an IgE-mediated reaction. This is t...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)59428-x

    authors: MacLeod TL,Eisen A,Sussman GL

    更新日期:1987-09-01 00:00:00

  • Increased odds of live birth in fresh in vitro fertilization cycles with shorter ovarian stimulation.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2016.09.044

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    更新日期:2017-01-01 00:00:00

  • A reduction in the number of unwanted pregnancies among female army draftees through a controlled intervention.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)00252-5

    authors: Malovizky D,Lavi B,Modan B

    更新日期:1997-09-01 00:00:00

  • Antibodies to beta2 glycoprotein I are associated with in vitro fertilization implantation failure as well as recurrent miscarriage: results of a prevalence study.

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    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

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    更新日期:1998-11-01 00:00:00

  • Catheter type does not affect the outcome of intrauterine insemination treatment: a prospective randomized study.

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    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Fancsovits P,Toth L,Murber A,Szendei G,Papp Z,Urbancsek J

    更新日期:2005-03-01 00:00:00

  • Ovulation induction in women with premature ovarian failure: a prospective, crossover study.

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    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)54863-8

    authors: Rosen GF,Stone SC,Yee B

    更新日期:1992-02-01 00:00:00

  • Infertility caused by bilateral testicular masses secondary to congenital adrenal hyperplasia (21-hydroxylase deficiency).

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)47485-6

    authors: Cutfield RG,Bateman JM,Odell WD

    更新日期:1983-12-01 00:00:00

  • Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.

    abstract:OBJECTIVE:To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids. DESIGN:Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre-embryos. SETTING:Tertiary care academic center. PATIENTS:From ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)56943-x

    authors: Queenan JT Jr,Veeck LL,Seltman HJ,Muasher SJ

    更新日期:1994-09-01 00:00:00

  • Voluntary and involuntary childlessness in female veterans: associations with sexual assault.

    abstract:OBJECTIVE:To assess associations between lifetime sexual assault and childlessness in female veterans. DESIGN:Cross-sectional, computer-assisted telephone interview study. SETTING:Two Midwestern Veterans Administration (VA) medical centers. PATIENT(S):A total of 1,004 women aged ≤52 years, VA-enrolled between 2000 a...

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    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.fertnstert.2014.04.042

    authors: Ryan GL,Mengeling MA,Booth BM,Torner JC,Syrop CH,Sadler AG

    更新日期:2014-08-01 00:00:00

  • Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis.

    abstract:OBJECTIVE:To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. DESIGN:Clinical trial. SETTING:Reproductive unit of a university teaching hospital. PATIENT:A patient of obstructive azoospermia with defective spermiogenesis. INTERVENTION:Testicular biopsy after scrotal exploration...

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    pub_type: 临床试验,杂志文章

    doi:10.1016/s0015-0282(16)58406-4

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    更新日期:1996-07-01 00:00:00

  • Preservation techniques for human semen.

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    pub_type: 杂志文章

    doi:

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    更新日期:1981-05-01 00:00:00

  • Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success.

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    pub_type: 杂志文章

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    authors: Garrido N,Bellver J,Remohí J,Simón C,Pellicer A

    更新日期:2011-07-01 00:00:00

  • Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity.

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    pub_type: 临床试验,杂志文章

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    更新日期:2000-10-01 00:00:00

  • Prevalence of hyperandrogenemia among nonhirsute oligo-ovulatory women.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)80089-1

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    更新日期:1997-03-01 00:00:00

  • Classification of endometriotic implants by morphologic appearance and capacity to synthesize prostaglandin F.

    abstract::The severity of the symptoms of endometriosis has not always correlated well with the anatomic severity of the disease. This lack of correlation may be due to variations in the metabolic activity of the endometriotic implants present at different stages of the disease. Because prostaglandin F (PGF) has been implicated...

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    pub_type: 杂志文章

    doi:

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    更新日期:1986-11-01 00:00:00

  • Comparison of low-dose human menopausal gonadotropin and micronized 17beta-estradiol supplementation in in vitro maturation cycles with thin endometrial lining.

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    pub_type: 杂志文章

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  • Gonadotropin suppression for the treatment of karyotypically normal spontaneous premature ovarian failure: a controlled trial.

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    pub_type: 临床试验,杂志文章

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    更新日期:1992-01-01 00:00:00

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    更新日期:2000-04-01 00:00:00

  • Prognosis of fertility of men with sperm agglutinins in the serum.

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    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)40388-2

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    更新日期:1974-05-01 00:00:00

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)53536-5

    authors: Germond M,Senn A,Reymond O,de Grandi P

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    pub_type: 杂志文章

    doi:10.1016/s0015-0282(02)03337-x

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