Abstract:
OBJECTIVE:To evaluate the effects of tamoxifen treatment on sperm density, motility, vitality, and morphology. DESIGN:Placebo-controlled, randomized study. SETTING:Outpatient department. INTERVENTIONS:Patients were assigned to two comparable groups: group A (n = 122) was treated with 10 mg tamoxifen twice daily for a period of 3 months and group B (n = 117) was given placebo for the same period of time, following a previously randomized design. MAIN OUTCOME MEASURES:In every patient sperm density, motility, viability, and morphology were evaluated 3 months after cessation of treatment. RESULTS:Mean sperm density in group A improved significantly with a more pronounced improvement in severe oligozoospermic men. Sperm density was found significantly improved compared with group B. Dead spermatozoa in group A significantly decreased after tamoxifen treatment and were also found significantly decreased compared with group B. CONCLUSION:It is concluded that tamoxifen exerts a beneficial effect on sperm density and number of live spermatozoa but it has no substantial effect in sperm motility and morphology.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Kotoulas IG,Cardamakis E,Michopoulos J,Mitropoulos D,Dounis Adoi
10.1016/s0015-0282(16)56705-3subject
Has Abstractpub_date
1994-05-01 00:00:00pages
911-4issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(16)56705-3journal_volume
61pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. DESIGN:Prospective clinical and laboratory study. SETTING:University-based laboratory ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.05.003
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To evaluate endometrial adhesion and invasion of peritoneal mesothelium. DESIGN:Descriptive study using confocal laser-scanning microscopy. SETTING:University-based laboratory. PATIENT(S):Women undergoing surgery for benign conditions. INTERVENTION(S):Fluorescence-labeled peritoneal mesothelial cells (PMC...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04834-3
更新日期:2003-03-01 00:00:00
abstract::A group of 216 vasovasostomized men were tested with the mixed antiglobulin reaction for immunoglobulin (Ig)G, IgA, and secretory IgA antisperm antibodies bound to the sperm membrane. Free antisperm antibodies in serum and seminal plasma were detected with the gelatin agglutination test and the tray agglutination test...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:To determine whether the peripheral blood concentration of CD56(+)/CD16(-)/CD3(-) cells, the main natural killer (NK) subpopulation that colonizes the endometrium in the middle and late secretory phase, can be related to fertility or infertility status. DESIGN:A case control study. SETTING:Immunopathology d...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00778-7
更新日期:2003-09-01 00:00:00
abstract::Tumor necrosis factor-alpha stimulates the secretion of vascular endothelial growth factor by cultured human oviductal epithelial cells and stromal fibroblasts. Tumor necrosis factor-alpha-stimulated vascular endothelial growth factor secretion by these cells may control oviductal fluid secretion by regulating vascula...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.05.082
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To study the morphological changes of apoptotic oocytes, and rates of in vitro maturation and apoptosis of human oocytes in relation to age. DESIGN:Prospective comparative study. SETTING:Reproductive medicine center. PATIENT(S):Women undergoing surgery for ovarian cysts. INTERVENTION(S):Oocytes were incub...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)01597-1
更新日期:2000-12-01 00:00:00
abstract::To test the antiestrogenic action of paramethasone acetate (PA), a group of five postmenopausal women were treated in two ways. For phase I, PA + mestranol, 6 mg + 80 micrograms per day for 10 days, was administered. Ten days were allowed for withdrawal of medication. For phase II, mestranol, 80 micrograms per day for...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::Four individuals with a complaint of infertility were evaluated after a semen analysis had demonstrated no motility. The semen analyses were otherwise normal, with the exception of a low count in one subject. All had normal percentages of living sperm. One of the individuals had chronic respiratory disease, and two ot...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47549-7
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of compound genetic abnormalities in patients who are carriers of cystic fibrosis mutations. DESIGN:Case report. SETTING:Tertiary referral center for male infertility. PATIENT(S):Between 2000 and 2005, 65 patients were identified to be carriers of cystic fibrosis transmembrane r...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.07.1537
更新日期:2007-06-01 00:00:00
abstract::Synthetic LH-RH is a polypeptide that is structurally identical to natural LH-RH. It has been used as a safe ovulation induction agent. A case is presented in which a patient had an anaphylactic reaction when treated with LH-RH by IV infusion. Positive skin testing confirmed this as an IgE-mediated reaction. This is t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59428-x
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of prolonged ovarian stimulation on pregnancy outcomes in IVF cycles with fresh day 3 ET. DESIGN:Retrospective cohort study. SETTING:University-affiliated center. PATIENT(S):All patients initiating their first IVF cycle with fresh day 3 ET. Prolonged ovarian stimulation was define...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.09.044
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To assess the possibility of reducing the risk of unwanted pregnancy through a controlled intervention program that was based on a sex education workshop. DESIGN:Educational intervention study. SETTING:Newly drafted women in a central absorption army base in Israel. PATIENT(S):One thousand seven hundred ni...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00252-5
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether antiphospholipid and related autoantibodies are associated with IVF implantation failure as well as with recurrent spontaneous miscarriage. DESIGN:Prevalence study. SETTING:University teaching hospital and associated IVF unit. PATIENT(S):Patients with at least three consecutive first...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00312-4
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:To compare the main outcome of IUI with the Gynetics catheter (Gynetics Medical Products, Hamont-Achel, Belgium) or the Makler cannula (Sefi-Medical Instruments, Haifa, Israel). DESIGN:Prospective, randomized study. SETTING:Infertility and endocrinology unit in a university hospital. PATIENT(S):Two hundred...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2004.08.034
更新日期:2005-03-01 00:00:00
abstract::A prospective crossover study comparing ovulation induction techniques in eight women with premature ovarian failure is presented. These patients were treated with FSH rebound techniques using the GnRH-a, LA, alone in one treatment cycle and the same plus menopausal gonadotropins in the other treatment cycle. Two wome...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54863-8
更新日期:1992-02-01 00:00:00
abstract::Two male cousins with partial 21-hydroxylase deficiency presented with bilateral testicular masses and infertility. In both cases, the testicular masses, consisting of adrenocorticotropic hormone-dependent pluripotential cells, were thought to play a major etiologic role in infertility. The administration of very smal...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47485-6
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids. DESIGN:Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre-embryos. SETTING:Tertiary care academic center. PATIENTS:From ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56943-x
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To assess associations between lifetime sexual assault and childlessness in female veterans. DESIGN:Cross-sectional, computer-assisted telephone interview study. SETTING:Two Midwestern Veterans Administration (VA) medical centers. PATIENT(S):A total of 1,004 women aged ≤52 years, VA-enrolled between 2000 a...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2014.04.042
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. DESIGN:Clinical trial. SETTING:Reproductive unit of a university teaching hospital. PATIENT:A patient of obstructive azoospermia with defective spermiogenesis. INTERVENTION:Testicular biopsy after scrotal exploration...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)58406-4
更新日期:1996-07-01 00:00:00
abstract::Sperm banking with the relatively simple and economical biologic freezer (Linde BF-5; Union Carbide Corporation, Linde Division, New York, N.Y.) was compared with controlled-rate freezer (Linde CRF-1; Union Carbide), using different freezing rates and cryoprotective media. The results were assessed by comparing prefre...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVE:To report the use of cumulative live-birth rates (CLBRs) per ovarian stimulation cycle to measure the success of IVF is proving to be the most accurate method for advising couples who failed to conceive, although the accuracy yielded is relatively low, and cycle outcome is highly dependent on the number of em...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.05.008
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects on the lipid pattern and insulin sensitivity of hirsute women of an oral contraceptive pill containing 30 microg of ethinyl estradiol and 150 microg of desogestrel. DESIGN:Prospective clinical study. SETTING:Tertiary care institutional hospital. PATIENT(S):16 hirsute women. INTERVE...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(00)00718-4
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. DESIGN:Retrospective cohort controlled. SETTING:Tertiary care university-based outpatient clinic. PATIENT(S):Thirty-two consecutive nonhirsute oligo-ovulator...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)80089-1
更新日期:1997-03-01 00:00:00
abstract::The severity of the symptoms of endometriosis has not always correlated well with the anatomic severity of the disease. This lack of correlation may be due to variations in the metabolic activity of the endometriotic implants present at different stages of the disease. Because prostaglandin F (PGF) has been implicated...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVE:A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer. DESIGN:Retrospective study. SETTING:McGill Reproductive Center, Montreal, Canada. PATIENT(S):Women with endometrial thickness <6 mm on days 6-10 ultrasound (US) scan of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1750
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To determine if gonadotropin suppression improves ovarian follicle function or ovulation rates in patients with karyotypically normal spontaneous premature ovarian failure. DESIGN:Prospective, double-blind, placebo-controlled, crossover trial. SETTING:Tertiary care research institution. INTERVENTIONS:Two i...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)54775-x
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of spontaneous pregnancy in women who were not actively undergoing therapy after a successful attempt at IVF/intracytoplasmic sperm injection and to characterize its pattern of occurrence. DESIGN:Retrospective postal questionnaire. SETTING:An assisted reproduction unit at a univer...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00609-3
更新日期:2000-04-01 00:00:00
abstract::A retrospective study of 254 infertile men with serum sperm agglutination titers ranging from 4 to 1024 determined by the Kibrick agglutination test between 1954 and 1968 and reexamined in the 1970s is presented. 36 of the subjects had become fertile in the years following the testing, 30 of whom were normospermic. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)40388-2
更新日期:1974-05-01 00:00:00
abstract::Different protocols using agonists of GnRH-a have been proposed for the ovarian stimulation in IVF cycles. In case of stimulation failure with the flare-up protocol, we have investigated whether an immediate switch to pituitary blockade by the long-acting analog may avoid the cycle to be canceled. This procedure allow...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53536-5
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To correlate the diagnosis of endometriosis in lesions excised at laparoscopy with pathologic diagnosis. DESIGN:Prospective study. SETTING:U.S. government research hospital. PATIENT(S):Women with chronic pelvic pain thought to be due to endometriosis. INTERVENTION(S):Excision of lesions suspicious for end...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)03337-x
更新日期:2002-10-01 00:00:00