Antisperm antibodies and fertility after vasovasostomy: a follow-up study of 216 men.

Abstract:

:A group of 216 vasovasostomized men were tested with the mixed antiglobulin reaction for immunoglobulin (Ig)G, IgA, and secretory IgA antisperm antibodies bound to the sperm membrane. Free antisperm antibodies in serum and seminal plasma were detected with the gelatin agglutination test and the tray agglutination test. The results were related to the conception rates. In a subgroup with a pure IgG response, the conception rate reached 85.7%, whereas only 42.9% of the men who also had IgA on the sperm induced pregnancy. When 100% of the spermatozoa were covered with IgA, the conception rate was reduced to 21.7%. The combination of IgA on all sperm and a strong immune response (titer in serum greater than or equal to 256) was associated with a conception rate of zero.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Meinertz H,Linnet L,Fogh-Andersen P,Hjort T

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

315-21

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)53710-8

journal_volume

54

pub_type

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