Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.

Abstract:

OBJECTIVE:To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids. DESIGN:Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre-embryos. SETTING:Tertiary care academic center. PATIENTS:From January 1987 to December 1993, 521 patients who were < 40 years of age underwent 628 thawed embryo transfers. MAIN OUTCOME MEASURE:Pregnancy and implantation rates per thawed embryo transfer cycle. RESULTS:A total 1,987 pre-embryos survived the thawing process and were used in 628 thaw-transfer cycles. Transfer was performed in a natural cycle 2 days after the LH peak or on day 17 of a programmed cycle using a GnRH-agonist and hormone replacement therapy protocol; 182 pregnancies were established (182/628; 29%). Similar pregnancy rates were seen in the natural cycle (112/398; 28%) and the programmed cycle (70/230; 30%). The implantation rates were similar in the two methods of transfer cycles (11.9% versus 10.3%, natural versus programmed cycle). There were no significant differences in clinical or ongoing pregnancy rates in a natural or programmed cycle, correcting for the number of cryopreserved-thawed pre-embryos transferred. Patient's age at the time of freezing and the number of cryopreserved-thawed pre-embryos transferred are more important determinants of pregnancy than the type of cycle in which transfer occurs. CONCLUSION:Transferring cryopreserved-thawed pre-embryos in a natural or programmed cycle yields similar pregnancy results.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Queenan JT Jr,Veeck LL,Seltman HJ,Muasher SJ

doi

10.1016/s0015-0282(16)56943-x

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

545-50

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)56943-X

journal_volume

62

pub_type

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