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Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages.

Abstract：

OBJECTIVE:To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples. DESIGN:Prospective cohort study. SETTING:Tertiary university referral center. PATIENT(S):Women (n = 49) with recurrent idiopathic miscarriages. INTERVENTION(S):In vitro fertilization with preimplantation genetic diagnosis for aneuploidy screening. MAIN OUTCOME MEASURE(S):Ongoing pregnancy rate (PR) and aneuploidy rate. RESULT(S):The aneuploidy rate was, respectively, 43.85% and 66.95% in the younger and older group. The ongoing PR per cycle was 25.71% in the younger and 2.94% in the older patients. CONCLUSION(S):There is no therapeutic evidence to prescribe IVF with or without preimplantation genetic diagnosis for aneuploidy screening for this heterogeneous group of patients.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Platteau P,Staessen C,Michiels A,Van Steirteghem A,Liebaers I,Devroey P

doi

10.1016/j.fertnstert.2004.06.071

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

393-7; quiz 525-6

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(04)02854-7

journal_volume

83

pub_type

杂志文章

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