Assessment of female sexual dysfunction: review of validated methods.


OBJECTIVE:To review validated methods for the assessment of female sexual function in clinical trials. DESIGN:Evaluation of recent peer-review literature on sexual function assessment in women. SETTING:International conference on androgen insufficiency in women. PATIENT(S):Women with sexual dysfunction due to androgen insufficiency or other causes. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Measures of sexual function in women. RESULT(S):Design and measurement problems in the assessment of sexual functioning in women have limited clinical trials in female sexual dysfunction. Objective measures, such as vaginal photoplethysmography or Duplex ultrasound, have been used in some studies but lack standardization and are unsuitable for use in large-scale clinical trials. A variety of interview methods, validated questionnaires, and event log measures have been used for assessing sexual function in recent trials of androgen replacement therapy. Each of these methods has distinct advantages and disadvantages, although validated questionnaires have provided the most reliable findings to date. Recent Food and Drug Administration guidelines on assessment of female sexual function in clinical trials are critically reviewed. CONCLUSION(S):Despite their prevalence and clinical significance, sexual problems in women have often been neglected in clinical trials. A major obstacle in the design of clinical trials in this area has been the need for sensitive and reliable measures of outcome. Of the currently available measures, self-reported event logs or questionnaires are best suited for research or clinical assessment of female sexual function.


Fertil Steril


Fertility and sterility


Rosen RC





Has Abstract


2002-04-01 00:00:00










77 Suppl 4


  • Embryo transfer practices and multiple births resulting from assisted reproductive technology: an opportunity for prevention.

    abstract:OBJECTIVE:To evaluate assisted reproductive technology (ART) ET practices in the United States and assess the impact of these practices on multiple births, which pose health risks for both mothers and infants. DESIGN:Retrospective cohort analysis using the National ART Surveillance System data. SETTING:US fertility c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kissin DM,Kulkarni AD,Mneimneh A,Warner L,Boulet SL,Crawford S,Jamieson DJ,National ART Surveillance System (NASS) group.

    更新日期:2015-04-01 00:00:00

  • Immunologic challenges of human reproduction: an evolving story.

    abstract::Characterization of the implanting human fetus as an allograft prompted a field of research in reproductive immunology that continues to fascinate and perplex scientists. Paternal- or partner-derived alloantigens are present in the maternal host at multiple times during the reproductive process. They begin with exposu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Hyde KJ,Schust DJ

    更新日期:2016-09-01 00:00:00

  • Aspiration flow cytometry of the testes in the evaluation of spermatogenesis in the infertile male.

    abstract::Deoxyribonucleic acid (DNA) flow cytometry of testicular tissue has been demonstrated to be a quantitative means of assessing spermatogenesis. This study evaluates testes aspirates and DNA flow cytometry in the evaluation of the infertile male. Testicular tissue obtained from 12 men who underwent bilateral orchiectomy...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kaufman DG,Nagler HM

    更新日期:1987-08-01 00:00:00

  • Heterotopic abdominal pregnancy treated at laparoscopy.

    abstract:OBJECTIVE:To report a case of laparoscopic treatment of a heterotopic primary abdominal pregnancy after IVF with preservation of the concurrent intrauterine pregnancy. DESIGN:Case report. SETTING:University-based IVF program. PATIENT(S):A woman with a heterotopic abdominal pregnancy after IVF-ET. INTERVENTION(S):Pi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pisarska MD,Casson PR,Moise KJ Jr,DiMaio DJ,Buster JE,Carson SA

    更新日期:1998-07-01 00:00:00

  • Effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilization/intracytoplasmic sperm injection.

    abstract:OBJECTIVE:To investigate whether levothyroxine (LT4) treatment has beneficial effects on IVF results and pregnancy outcome in infertile patients with subclinical hypothyroidism undergoing IVF/intracytoplasmic sperm injection (ICSI). DESIGN:Prospective, randomized trial. SETTING:University-affiliated infertility clini...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Kim CH,Ahn JW,Kang SP,Kim SH,Chae HD,Kang BM

    更新日期:2011-04-01 00:00:00

  • Variations in seminal plasma constituents from fertile, subfertile, and vasectomized azoospermic men.

    abstract::Freshly ejaculated semen specimens from 20 normal fertile, 11 subfertile, and 20 vasectomized men whose semen analyses had reached complete azoospermia were compared. The mean levels of seminal acid phosphatase were significantly higher in the vasectomized men. The mean values of sialic acid in normal and postvasect...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nun S,Musacchio I,Epstein JA

    更新日期:1972-05-01 00:00:00

  • Complete evaluation of anatomy and morphology of the infertile patient in a single visit; the modern infertility pelvic ultrasound examination.

    abstract::The comprehensive "one-stop shop" ultrasound evaluation of an infertile woman, performed around cycle days 5 to 9, will reveal abundant information about the anatomy and morphology of the pelvic organs and thereby avoid costly radiation and iodinated contrast exposure. We propose a two-dimensional and three-dimensiona...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Groszmann YS,Benacerraf BR

    更新日期:2016-06-01 00:00:00

  • Effects of pentoxifylline on human sperm motility in normospermic individuals using computer-assisted analysis.

    abstract:OBJECTIVE:To determine if pentoxifylline has an in vitro effect on human sperm motility in subjects with normal semen analysis. DESIGN:Prospective, longitudinal study of the effect of pentoxifylline on normospermic semen samples using computerized analysis. SETTING:The Assisted Conception Unit, Royal Maternity Hospit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lewis SE,Moohan JM,Thompson W

    更新日期:1993-02-01 00:00:00

  • A preliminary concept, deduced from cytogenetic analyses, for explaining different types of multipronuclear oocytes obtained after intracytoplasmic sperm injection.

    abstract::Oocytes with three or more pronuclei and one or two polar bodies arising after intracytoplasmic sperm injection were analyzed cytogenetically, and the data were used to develop a general model explaining the possible origin of the abnormal pronuclear stages. The mechanisms, either separately or in variable combination...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rosenbusch BE

    更新日期:2010-11-01 00:00:00

  • Assessing the role of endometrial alteration among obese patients undergoing assisted reproduction.

    abstract::Obesity seems to exert a small but important extraovarian effect that may influence cycle outcome during assisted reproduction. Future investigation should focus on elucidating whether the endometrium is truly responsible for this deficit, and if it is, determining the mechanisms involved. ...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章


    authors: Levens ED,Skarulis MC

    更新日期:2008-06-01 00:00:00

  • Assessment of interlaboratory and intralaboratory sperm morphology readings with the use of a Hamilton Thorne Research integrated visual optical system semen analyzer.

    abstract:OBJECTIVE:To evaluate the level of variance produced in a multicenter study with the use of a computer-assisted sperm morphology analyzer. DESIGN:A multicenter, prospective, blinded study. SETTING:Assisted reproduction research laboratories. PATIENT(S):Semen samples produced for assisted reproductive procedures. IN...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Coetzee K,Kruger TF,Lombard CJ,Shaughnessy D,Oehninger S,Ozgür K,Pomeroy KO,Muller CH

    更新日期:1999-01-01 00:00:00

  • Unrecognized lithopedion with 35 years' evolution diagnosed on computed tomographic scan.

    abstract::We report an incidental finding of unrecognized lithopedion resulting from an old abdominal pregnancy with 35 years' evolution. Structures of the calcified fetus are seen clearly on abdominopelvic computed tomographic images. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sun G,Li M,Lu Y

    更新日期:2010-06-01 00:00:00

  • Detection of endometrial pathology using saline infusion sonography versus gel instillation sonography: a prospective cohort study.

    abstract:OBJECTIVE:To compare saline infusion sonography (SIS) with gel instillation sonography (GIS) in terms of feasibility and diagnostic accuracy. DESIGN:Prospective cohort study. SETTING:Leuven University bleeding clinic. PATIENT(S):A total of 804 patients: two consecutive cohorts of 402 women undergoing SIS or GIS. IN...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Werbrouck E,Veldman J,Luts J,Van Huffel S,Van Schoubroeck D,Timmerman D,Van den Bosch T

    更新日期:2011-01-01 00:00:00

  • Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized, double-blind, placebo-controlled trial.

    abstract:OBJECTIVE:To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates. DESIGN:Randomized double-blinded placebo-controlled trial. SETTING:Academic. PATIENT(S):Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Hong KH,Forman EJ,Werner MD,Upham KM,Gumeny CL,Winslow AD,Kim TJ,Scott RT Jr

    更新日期:2014-12-01 00:00:00

  • Occupationally related exposures and reduced semen quality: a case-control study.

    abstract:OBJECTIVE:To determine whether there is an association between abnormal semen parameters and occupational exposures to organic solvents, metals, and pesticides. DESIGN:Case-control study using three case groups based on different cutoff values for semen parameters and one standard reference group. SETTING:University ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tielemans E,Burdorf A,te Velde ER,Weber RF,van Kooij RJ,Veulemans H,Heederik DJ

    更新日期:1999-04-01 00:00:00

  • Requirements for research investigations to clarify the relationships and management of menstrual abnormalities in women with hemostatic disorders.

    abstract::This article highlights a comprehensive range of research investigations which are required to clarify the relationships between the symptom of excessively heavy menstrual bleeding and different disorders of systemic hemostasis and their management. The need for these investigations was stimulated by an international ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Fraser IS,Bonnar J,Peyvandi F

    更新日期:2005-11-01 00:00:00

  • Correlation of ultrasound-measured venous size and reversal of flow with Valsalva with improvement in semen-analysis parameters after varicocelectomy.

    abstract::We studied 68 men with varicoceles to determine preoperative parameters that are associated with improvements in semen analysis after varicocelectomy. Ultrasound-measured venous diameter and reversal of flow were found to correlate with successful outcome. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Schiff JD,Li PS,Goldstein M

    更新日期:2006-07-01 00:00:00

  • Immunologic studies of male infertility.

    abstract::Infertile men with azo- or oligospermia of unknown cause were investigated for evidence of testicular autoimmunity. Testicular germinal cell antibodies were found in 14% of the patients, compared with 5% of normal men, and 21% had spermatozoal antibodies, compared with 5% of the normal subjects. One-third had positive...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wall JR,Stedronska J,David RD,Harrison RF,Goriup D,Lessof MH

    更新日期:1975-10-01 00:00:00

  • The impact of hydrosalpinx on successful pregnancy in tubal factor infertility treated by in vitro fertilization.

    abstract:OBJECTIVE:To determine the impact of hydrosalpinx on pregnancy rates in patients undergoing IVF for infertility caused by tubal disease. DESIGN:Review of the records of all patients who had undergone IVF for tubal factor infertility at our institution between May 1988 and October 1994. SETTING:A university-sponsored,...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Blazar AS,Hogan JW,Seifer DB,Frishman GN,Wheeler CA,Haning RV

    更新日期:1997-03-01 00:00:00

  • Uterus transplantation: animal research and human possibilities.

    abstract::Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Brännström M,Diaz-Garcia C,Hanafy A,Olausson M,Tzakis A

    更新日期:2012-06-01 00:00:00

  • What serial hCG can tell you, and cannot tell you, about an early pregnancy.

    abstract::The serial measurement of serum hCG concentrations is an important clinical tool used to differentiate normal from abnormal pregnancies. At hCG values below which ultrasonography can be diagnostic, the comparison of a patient's hCG dynamics to those of established expected curves of rise or fall can aid the clinician ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Seeber BE

    更新日期:2012-11-01 00:00:00

  • Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study.

    abstract:OBJECTIVE:To assess whether provision of an educational DVD was more effective in increasing the uptake of elective single embryo transfers (eSET) than an educational brochure in an IVF population. DESIGN:Randomized controlled trial. SETTING:Private IVF clinic. PATIENT(S):One hundred thirty-one couples starting thei...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Hope N,Rombauts L

    更新日期:2010-07-01 00:00:00

  • Tamoxifen citrate therapy in male infertility.

    abstract::A prospective, randomized, double-blind study with crossover, using tamoxifen (TAM) (Nolvadex, ici Pharma, Missisauga, Canada) 20 mg/day and placebo (p) for 6 months each, was conducted in 16 infertile men with idiopathic oligozoospermia. Baseline sperm count was 17.092 +/- 3.09 (10(6)/ml). Hormonal profile was perfor...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: AinMelk Y,Belisle S,Carmel M,Jean-Pierre T

    更新日期:1987-07-01 00:00:00

  • Pubertal development of the first cohort of young adults conceived by in vitro fertilization in the United States.

    abstract:OBJECTIVE:To characterize pubertal development of the first generation of young adults born as a result of in vitro fertilization (IVF). Demographic, clinical, and body size characteristics were examined regarding developmental milestones. DESIGN:Cross-sectional. SETTING:Academic center. PATIENT(S):Young adults (18-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Beydoun HA,Sicignano N,Beydoun MA,Bocca S,Stadtmauer L,Oehninger S

    更新日期:2011-02-01 00:00:00

  • Leukocyte alkaline phosphatase monitoring of ovarian function in normal and clomiphene-treated cycles.

    abstract::Daily leukocyte alkaline phosphatase activity (LAP), basal body temperature (BBT), fern test (FT) and serum luteinizing hormone (LH) were determined during 15 normal menstrual cycles and 10 cycles treated with clomiphene citrate. A rise in LAP activity, as determined by LAP-relative score (LAP-RS), was observed durin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Polishuk WZ,Diamant YZ

    更新日期:1973-04-01 00:00:00

  • Luteinizing hormone and human chorionic gonadotropin receptors in human corpora lutea from clomiphene citrate-induced cycles.

    abstract::Midluteal phase corpora lutea (CL) obtained from women induced with 50 mg (n = 5), 100 mg (n = 5), and 150 mg (n = 5) of clomiphene citrate (CC) were measured for luteinizing hormone/human chorionic gonadotropin (LH/hCG) concentrations and cytosol progesterone (P) and 17 alpha-hydroxyprogesterone (17-OHP) and compared...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yeko TR,Khan-Dawood FS,Dawood MY

    更新日期:1990-10-01 00:00:00

  • Protein, progesterone, and protease inhibitors in uterine and peritoneal fluids of women with endometriosis.

    abstract::This study was undertaken to determine whether women with endometriosis have altered protein, progesterone (P), and protease inhibitor concentrations in their uterine fluid and peritoneal fluid (PF) compared with controls at different phases of the menstrual cycle. Uterine flushings (UFs), PF, and blood were obtained ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fazleabas AT,Khan-Dawood FS,Dawood MY

    更新日期:1987-02-01 00:00:00

  • A direct effect of antiovulatory compounds on human testicular biosynthesis in vitro.

    abstract::Human testes, removed in treating patients for prostatic carcinoma, were used. Tissues were homogenized and incubated in vitro with labeled progesterone and 2 different antiovulatories, lynestrenol (17alpha-ethin yl-17beta-hydroxy-estr-4-one) and MK 665 (17alpha-chloroethinyl-19-nor-4 ,9(10)-androstadiene-17beta-ol-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Balatti JJ,Claret A,Rosner JM

    更新日期:1967-05-01 00:00:00

  • Cost-effectiveness analysis of preimplantation genetic screening and in vitro fertilization versus expectant management in patients with unexplained recurrent pregnancy loss.

    abstract:OBJECTIVE:To determine whether in vitro fertilization with preimplantation genetic screening (IVF/PGS) is cost effective compared with expectant management in achieving live birth for patients with unexplained recurrent pregnancy loss (RPL). DESIGN:Decision analytic model comparing costs and clinical outcomes. SETTIN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Murugappan G,Ohno MS,Lathi RB

    更新日期:2015-05-01 00:00:00

  • The M235T polymorphism of the angiotensinogen gene in women with polycystic ovary syndrome.

    abstract::To explore the relationship between variation in AGT M235T gene and the development of the polycystic ovary syndrome (PCOS) and its sequelae, in the present study we evaluated AGT polymorphism M235T in women with PCOS and in a control group. Moreover, to detect any relationship between AGT M235T variation and intermed...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zulian E,Sartorato P,Schiavi F,Moghetti P,Castello R,Mantero F,Opocher G,Scaroni C

    更新日期:2005-11-01 00:00:00